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Esomeprazole

Medication proton pump inhibitor digestive
Aka: Nexium
Brands seen in Singapore: Nexium, Sprazole, Esoz, Escopro, Emanera
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
HealthHub: reflux disease and ulcers of the gut
When to take
HealthHub: 60 minutes before a meal, swallowed whole
Take with
Water · HealthHub: tablets not to be chewed or crushed
Pros & cons
Pros
  • SG label: 40 mg once daily for erosive oesophagitis
  • HealthHub: relief often within days to weeks
  • SG label: no dose change needed in kidney impairment
Cons
  • HealthHub: headache, abdominal pain, diarrhoea, wind
  • HealthHub: may lower magnesium levels
  • HealthHub: higher fracture risk with osteoporosis
Sources
  1. HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally) · read 2026-08-27
    what it says
    “All 18 registered esomeprazole products read Forensicclassification 'Prescription Only' — SIN11499P NEXIUM MUPS TABLET 40 mg · SIN16685P SPRAZOLE-40 · SIN14633P ESOZ TABLETS 40MG · SIN17003P ESCOPRO · SIN15233P EMANERA GASTRO-RESISTANT CAPSULES 40 MG”
  2. HealthHub (National Medication Information workgroup, SG) — Esomeprazole: what is this medication for · read 2026-08-27
    what it says
    “Esomeprazole is used to treat various conditions of the gastrointestinal tract including: Gastro-oesophageal reflux disease (a condition where the acid from the stomach goes back up the food tube and throat) … Ulcers of the gastrointestinal tract”
  3. HealthHub — Esomeprazole: how should I take this medication · read 2026-08-27
    what it says
    “Take this medication 60 minutes before a meal. Tablets should be swallowed whole with water and should not be chewed or crushed.”
  4. HealthHub — Esomeprazole: common side effects · read 2026-08-27
    what it says
    “Side effects of esomeprazole include headaches, gastrointestinal side effects (e.g. abdominal pain, diarrhoea, nausea and vomiting and wind).”
  5. HealthHub — Esomeprazole: what precautions should I take · read 2026-08-27
    what it says
    “This medication may cause the level of magnesium in your body to decrease … This medication may increase your risk of bone fractures if you have osteoporosis, a condition where your bones become weak or fragile.”
  6. HealthHub — Esomeprazole: precautions (masking and excipients) · read 2026-08-27
    what it says
    “This medication may hide the symptoms of other diseases. Inform your healthcare professional if you experience weight loss for no reason or are vomiting food or blood … Some preparations containing esomeprazole contain sucrose as an excipient.”
  7. HealthHub — Esomeprazole: what else should I know about this medication · read 2026-08-27
    what it says
    “Most people experience relief within the first few days to weeks of starting esomeprazole. Your doctor will usually prescribe this medication for 4-8 weeks initially to allow healing.”
  8. HealthHub — Esomeprazole: what food or medication should I avoid · read 2026-08-27
    what it says
    “Medications used to treat human immunodeficiency virus (HIV) infection. Certain blood thinners (e.g. clopidogrel). Certain anti-fungal medicines (e.g. itraconazole and ketoconazole). Certain medicines to treat mood (e.g. citalopram, imipramine and clomipramine). Certain medicines to treat seizures (e.g. phenytoin).”
  9. HealthHub — Esomeprazole: other interacting medicines · read 2026-08-27
    what it says
    “Other medicines such as digoxin, tacrolimus, methotrexate and iron salts.”
  10. Singapore National Drug Formulary (HSA/MOH) — NEXIUM MUPS TABLET 40 MG [SIN11499P], section 4.1 Therapeutic indications · read 2026-08-27
    what it says
    “Nexium MUPS tablets are indicated for: Gastroesophageal Reflux Disease (GERD): Treatment of erosive reflux esophagitis … Healing of Helicobacter pylori associated duodenal ulcer … Treatment of Zollinger Ellison Syndrome”
  11. Singapore National Drug Formulary — NEXIUM MUPS TABLET 40 MG [SIN11499P], section 4.2 Posology · read 2026-08-27
    what it says
    “Treatment of erosive reflux esophagitis: 40 mg once daily for 4 weeks … Symptomatic treatment of gastroesophageal reflux disease (GERD): 20 mg once daily in patients without esophagitis.”
  12. Singapore National Drug Formulary — NEXIUM MUPS [SIN11499P], impaired hepatic function · read 2026-08-27
    what it says
    “For patients with severe liver impairment, a maximum dose of 20 mg Nexium MUPS should not be exceeded”
  13. Singapore National Drug Formulary — NEXIUM MUPS [SIN11499P], Zollinger Ellison Syndrome dosing · read 2026-08-27
    what it says
    “the majority of patients can be controlled on doses between 80 to 160 mg esomeprazole daily … Safety information is limited in doses above 80 mg a day.”
  14. Singapore National Drug Formulary — NEXIUM MUPS [SIN11499P], impaired renal function · read 2026-08-27
    what it says
    “Dose adjustment is not required in patients with impaired renal function. Due to limited experience in patients with severe renal insufficiency, such patients should be treated with caution”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.