{"ok":true,"entry":{"slug":"esomeprazole","kind":"medication","name":"esomeprazole","aliases":["Nexium"],"brands_sg":["Nexium","Sprazole","Esoz","Escopro","Emanera"],"class":"proton pump inhibitor","tags":["digestive"],"use_for":"healthhub: reflux disease and ulcers of the gut","use_after":"healthhub: 60 minutes before a meal, swallowed whole","use_duration":null,"take_with":"water · healthhub: tablets not to be chewed or crushed","pros":["sg label: 40 mg once daily for erosive oesophagitis","healthhub: relief often within days to weeks","sg label: no dose change needed in kidney impairment"],"cons":["healthhub: headache, abdominal pain, diarrhoea, wind","healthhub: may lower magnesium levels","healthhub: higher fracture risk with osteoporosis"],"dose_note":"the singapore label for nexium mups states that in severe liver impairment 'a maximum dose of 20 mg Nexium MUPS should not be exceeded', and for zollinger-ellison syndrome that 'the majority of patients can be controlled on doses between 80 to 160 mg esomeprazole daily … Safety information is limited in doses above 80 mg a day'. routine reflux dosing on that same label is 20 mg or 40 mg once daily. no single general adult ceiling is stated. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["severe liver impairment — sg label caps the dose at 20 mg","healthhub: unexplained weight loss, or vomiting food or blood","healthhub: osteoporosis — fracture risk may be higher","healthhub: rare hereditary fructose intolerance (sucrose excipient)"],"clashes":[{"src":["hh_eso_avoid"],"note":"healthhub lists it among medicines to tell your professional about","with":"clopidogrel"},{"src":["hh_eso_avoid"],"note":"healthhub lists them among medicines to tell your professional about","with":"hiv medicines"},{"src":["hh_eso_avoid"],"note":"healthhub lists these antifungals among interacting medicines","with":"itraconazole and ketoconazole"},{"src":["hh_eso_avoid"],"note":"healthhub lists these mood medicines among interacting medicines","with":"citalopram, imipramine, clomipramine"},{"src":["hh_eso_avoid","hh_eso_avoid2"],"note":"healthhub lists these among interacting medicines","with":"phenytoin, digoxin, tacrolimus, methotrexate, iron salts"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally)","quote":"All 18 registered esomeprazole products read Forensicclassification 'Prescription Only' — SIN11499P NEXIUM MUPS TABLET 40 mg · SIN16685P SPRAZOLE-40 · SIN14633P ESOZ TABLETS 40MG · SIN17003P ESCOPRO · SIN15233P EMANERA GASTRO-RESISTANT CAPSULES 40 MG","accessed":"2026-08-27"},{"id":"hh_eso_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/esomeprazole","label":"HealthHub (National Medication Information workgroup, SG) — Esomeprazole: what is this medication for","quote":"Esomeprazole is used to treat various conditions of the gastrointestinal tract including: Gastro-oesophageal reflux disease (a condition where the acid from the stomach goes back up the food tube and throat) … Ulcers of the gastrointestinal tract","accessed":"2026-08-27"},{"id":"hh_eso_admin","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/esomeprazole","label":"HealthHub — Esomeprazole: how should I take this medication","quote":"Take this medication 60 minutes before a meal. Tablets should be swallowed whole with water and should not be chewed or crushed.","accessed":"2026-08-27"},{"id":"hh_eso_se","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/esomeprazole","label":"HealthHub — Esomeprazole: common side effects","quote":"Side effects of esomeprazole include headaches, gastrointestinal side effects (e.g. abdominal pain, diarrhoea, nausea and vomiting and wind).","accessed":"2026-08-27"},{"id":"hh_eso_prec","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/esomeprazole","label":"HealthHub — Esomeprazole: what precautions should I take","quote":"This medication may cause the level of magnesium in your body to decrease … This medication may increase your risk of bone fractures if you have osteoporosis, a condition where your bones become weak or fragile.","accessed":"2026-08-27"},{"id":"hh_eso_prec2","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/esomeprazole","label":"HealthHub — Esomeprazole: precautions (masking and excipients)","quote":"This medication may hide the symptoms of other diseases. Inform your healthcare professional if you experience weight loss for no reason or are vomiting food or blood … Some preparations containing esomeprazole contain sucrose as an excipient.","accessed":"2026-08-27"},{"id":"hh_eso_more","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/esomeprazole","label":"HealthHub — Esomeprazole: what else should I know about this medication","quote":"Most people experience relief within the first few days to weeks of starting esomeprazole. Your doctor will usually prescribe this medication for 4-8 weeks initially to allow healing.","accessed":"2026-08-27"},{"id":"hh_eso_avoid","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/esomeprazole","label":"HealthHub — Esomeprazole: what food or medication should I avoid","quote":"Medications used to treat human immunodeficiency virus (HIV) infection. Certain blood thinners (e.g. clopidogrel). Certain anti-fungal medicines (e.g. itraconazole and ketoconazole). Certain medicines to treat mood (e.g. citalopram, imipramine and clomipramine). Certain medicines to treat seizures (e.g. phenytoin).","accessed":"2026-08-27"},{"id":"hh_eso_avoid2","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/esomeprazole","label":"HealthHub — Esomeprazole: other interacting medicines","quote":"Other medicines such as digoxin, tacrolimus, methotrexate and iron salts.","accessed":"2026-08-27"},{"id":"ndf_nex_ind","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin11499p/","label":"Singapore National Drug Formulary (HSA/MOH) — NEXIUM MUPS TABLET 40 MG [SIN11499P], section 4.1 Therapeutic indications","quote":"Nexium MUPS tablets are indicated for: Gastroesophageal Reflux Disease (GERD): Treatment of erosive reflux esophagitis … Healing of Helicobacter pylori associated duodenal ulcer … Treatment of Zollinger Ellison Syndrome","accessed":"2026-08-27"},{"id":"ndf_nex_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin11499p/","label":"Singapore National Drug Formulary — NEXIUM MUPS TABLET 40 MG [SIN11499P], section 4.2 Posology","quote":"Treatment of erosive reflux esophagitis: 40 mg once daily for 4 weeks … Symptomatic treatment of gastroesophageal reflux disease (GERD): 20 mg once daily in patients without esophagitis.","accessed":"2026-08-27"},{"id":"ndf_nex_max","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin11499p/","label":"Singapore National Drug Formulary — NEXIUM MUPS [SIN11499P], impaired hepatic function","quote":"For patients with severe liver impairment, a maximum dose of 20 mg Nexium MUPS should not be exceeded","accessed":"2026-08-27"},{"id":"ndf_nex_zes","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin11499p/","label":"Singapore National Drug Formulary — NEXIUM MUPS [SIN11499P], Zollinger Ellison Syndrome dosing","quote":"the majority of patients can be controlled on doses between 80 to 160 mg esomeprazole daily … Safety information is limited in doses above 80 mg a day.","accessed":"2026-08-27"},{"id":"ndf_nex_renal","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin11499p/","label":"Singapore National Drug Formulary — NEXIUM MUPS [SIN11499P], impaired renal function","quote":"Dose adjustment is not required in patients with impaired renal function. Due to limited experience in patients with severe renal insufficiency, such patients should be treated with caution","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:19.87501+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}