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Empagliflozin

Medication SGLT2 inhibitor diabetesheart & blood pressure
Aka: Jardiance
Brands seen in Singapore: Jardiance, Empazox, Jardiance Duo, Glyxambi
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Type 2 diabetes, heart failure and kidney disease per NHS
When to take
Once a day · NHS: any time, SAMe time each day
Take with
Water · with or without food; tablets swallowed whole
Pros & cons
Pros
  • NHS: one tablet once a day, with or without food
  • HealthHub: also given in heart failure without diabetes
  • Label ceiling is 25 mg; 10 mg is the usual dose
Cons
  • Prescription-only in SG — all 10 register rows
  • Genital and urinary infections are common (HealthHub)
  • Rare dka and fournier's gangrene — HealthHub flags both
Sources
  1. NHS — Empagliflozin (brand name: Jardiance), Medicines A to Z landing page · read 2026-08-27
    what it says
    “Empagliflozin - Brand name: Jardiance … Find out how empagliflozin treats type 2 diabetes, heart failure and chronic kidney disease (CKD), and how to take it.”
  2. NHS — How and when to take empagliflozin, dosage section (page last reviewed 2 February 2023) · read 2026-08-27
    what it says
    “Empagliflozin tablets come in strengths of 10mg or 25mg. The usual starting dose for diabetes is 10mg, taken once a day. Your doctor may increase your dose to 25mg taken once a day.”
  3. NHS — How and when to take empagliflozin, timing and administration (same page) · read 2026-08-27
    what it says
    “The usual dose for heart failure or chronic kidney disease is 10mg once a day. You can take it any time of day, either with or without food … Swallow the tablets whole with a drink of water.”
  4. HealthHub (MOH Singapore) — Empagliflozin medication information leaflet, uses section (article last reviewed 19 May 2026) · read 2026-08-27
    what it says
    “Empagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor … If you suffer from heart failure, this medication can also be given to you to help with your heart condition, even if you do not have diabetes.”
  5. HealthHub (MOH Singapore) — Empagliflozin leaflet, common side effects section (same page) · read 2026-08-27
    what it says
    “The common side effects of Empagliflozin include: Genital infections … Urinary tract infection … Low blood pressure … Dehydration … Low blood sugar can happen and the chances … are increased when you take this medication with other medications used in diabetes”
  6. HealthHub (MOH Singapore) — Empagliflozin leaflet, rare but serious side-effects section (same page) · read 2026-08-27
    what it says
    “Diabetic ketoacidosis (DKA) … is a rare and serious side effect associated with this medication … Fournier's gangrene This medication is also very rarely associated with a serious bacterial infection in the genital or perineal area.”
  7. HealthHub (MOH Singapore) — Empagliflozin leaflet, precautions section (same page) · read 2026-08-27
    what it says
    “Have Type 1 diabetes mellitus (as this medication is not recommended for Type 1 diabetes mellitus) … Have any foot ulcers/ infections … Have a history of urinary tract infections”
  8. HealthHub (MOH Singapore) — Empagliflozin leaflet, precautions section, surgery item (same page) · read 2026-08-27
    what it says
    “Plan to go for any surgery or procedure (you may need to stop the medication temporarily at least 72 hours before that)”
  9. HealthHub (MOH Singapore) — Empagliflozin leaflet, 'When to temporarily stop Empagliflozin?' section (same page) · read 2026-08-27
    what it says
    “When feeling unwell eg. high fever, loss of appetite, diarrhoea, vomiting or at risk of dehydration … Surgical or dental procedure … A weight loss diet plan involving very low carbohydrate intake … Endurance physical activities … Fasting during Ramadan”
  10. HealthHub (MOH Singapore) — Empagliflozin leaflet, food and medication interactions section (same page) · read 2026-08-27
    what it says
    “Avoid taking alcohol with this medication as it may cause symptoms such as flushing, nausea, vomiting, headache, fast heartbeat, fast breathing, and giddiness.”
  11. DailyMed / FDA prescribing information (SPL) — JARDIANCE (empagliflozin) tablets, Dosage and Administration; label effective 3 May 2023, retrieved via the openFDA drug-label API · read 2026-08-27
    what it says
    “The recommended dose of JARDIANCE is 10 mg once daily in the morning, taken with or without food … For additional glycemic control, dose may be increased to 25 mg in patients tolerating JARDIANCE”
  12. HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset d_767279312753558cbf19d48344577084, full 5,511-row dump pulled 27 Aug 26 and filtered locally; 10 empagliflozin rows, 4 of them empagliflozin alone) · read 2026-08-27
    what it says
    “JARDIANCE FILM-COATED TABLETS 10MG · Prescription Only — JARDIANCE FILM-COATED TABLET 25MG · Prescription Only — EMPAZOX 10 Empagliflozin Film Coated Tablets 10 mg · Prescription Only — JARDIANCE DUO 12.5MG/1000MG · Prescription Only — GLYXAMBI 25 MG/5 MG · Prescription Only”
  13. HSA — forensic classification definitions used by the register (Prescription Only Medicine / Pharmacy Only / General Sale List) · read 2026-08-27
    what it says
    “Prescription-Only Medicine (POM): … can only be obtained from a doctor or from a pharmacist with a valid prescription”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.