{"ok":true,"entry":{"slug":"empagliflozin","kind":"medication","name":"empagliflozin","aliases":["Jardiance"],"brands_sg":["Jardiance","Empazox","Jardiance Duo","Glyxambi"],"class":"SGLT2 inhibitor","tags":["diabetes","heart-bp"],"use_for":"type 2 diabetes, heart failure and kidney disease per nhs","use_after":"once a day · nhs: any time, same time each day","use_duration":null,"take_with":"water · with or without food; tablets swallowed whole","pros":["nhs: one tablet once a day, with or without food","healthhub: also given in heart failure without diabetes","label ceiling is 25 mg; 10 mg is the usual dose"],"cons":["prescription-only in sg — all 10 register rows","genital and urinary infections are common (healthhub)","rare dka and fournier's gangrene — healthhub flags both"],"dose_note":"nhs states 'Empagliflozin tablets come in strengths of 10mg or 25mg. The usual starting dose for diabetes is 10mg, taken once a day. Your doctor may increase your dose to 25mg taken once a day', and 'The usual dose for heart failure or chronic kidney disease is 10mg once a day'; the us jardiance label gives the same ceiling — 'dose may be increased to 25 mg in patients tolerating JARDIANCE'; singapore registrations are 10 mg and 25 mg tablets plus fixed-dose combinations with metformin or linagliptin, all prescription only; as directed on the label or by your doctor or pharmacist","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["type 1 diabetes — healthhub says it is not recommended","foot ulcers or infections, or past dka — healthhub says say so","surgery or a procedure — healthhub notes a pause 72 hours before","feeling unwell, fever, vomiting or dehydrated — healthhub says pause"],"clashes":[{"src":["healthhub_empa_se"],"note":"healthhub: low blood sugar is more likely when it is taken with them","with":"other diabetes medicines (including insulin)"},{"src":["healthhub_empa_int"],"food":true,"note":"healthhub lists flushing, nausea, vomiting, headache, fast heartbeat and giddiness","with":"alcohol"},{"src":["healthhub_empa_pause"],"note":"healthhub groups these with dka risk and says to ask the doctor first","with":"very-low-carbohydrate diets, prolonged fasting, endurance events"}],"sources":[{"id":"nhs_empa","url":"https://www.nhs.uk/medicines/empagliflozin/","label":"NHS — Empagliflozin (brand name: Jardiance), Medicines A to Z landing page","quote":"Empagliflozin - Brand name: Jardiance … Find out how empagliflozin treats type 2 diabetes, heart failure and chronic kidney disease (CKD), and how to take it.","accessed":"2026-08-27"},{"id":"nhs_empa_how","url":"https://www.nhs.uk/medicines/empagliflozin/how-and-when-to-take-empagliflozin/","label":"NHS — How and when to take empagliflozin, dosage section (page last reviewed 2 February 2023)","quote":"Empagliflozin tablets come in strengths of 10mg or 25mg. The usual starting dose for diabetes is 10mg, taken once a day. Your doctor may increase your dose to 25mg taken once a day.","accessed":"2026-08-27"},{"id":"nhs_empa_how_food","url":"https://www.nhs.uk/medicines/empagliflozin/how-and-when-to-take-empagliflozin/","label":"NHS — How and when to take empagliflozin, timing and administration (same page)","quote":"The usual dose for heart failure or chronic kidney disease is 10mg once a day. You can take it any time of day, either with or without food … Swallow the tablets whole with a drink of water.","accessed":"2026-08-27"},{"id":"healthhub_empa","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/empagliflozin","label":"HealthHub (MOH Singapore) — Empagliflozin medication information leaflet, uses section (article last reviewed 19 May 2026)","quote":"Empagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor … If you suffer from heart failure, this medication can also be given to you to help with your heart condition, even if you do not have diabetes.","accessed":"2026-08-27"},{"id":"healthhub_empa_se","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/empagliflozin","label":"HealthHub (MOH Singapore) — Empagliflozin leaflet, common side effects section (same page)","quote":"The common side effects of Empagliflozin include: Genital infections … Urinary tract infection … Low blood pressure … Dehydration … Low blood sugar can happen and the chances … are increased when you take this medication with other medications used in diabetes","accessed":"2026-08-27"},{"id":"healthhub_empa_rare","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/empagliflozin","label":"HealthHub (MOH Singapore) — Empagliflozin leaflet, rare but serious side-effects section (same page)","quote":"Diabetic ketoacidosis (DKA) … is a rare and serious side effect associated with this medication … Fournier's gangrene This medication is also very rarely associated with a serious bacterial infection in the genital or perineal area.","accessed":"2026-08-27"},{"id":"healthhub_empa_warn","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/empagliflozin","label":"HealthHub (MOH Singapore) — Empagliflozin leaflet, precautions section (same page)","quote":"Have Type 1 diabetes mellitus (as this medication is not recommended for Type 1 diabetes mellitus) … Have any foot ulcers/ infections … Have a history of urinary tract infections","accessed":"2026-08-27"},{"id":"healthhub_empa_surg","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/empagliflozin","label":"HealthHub (MOH Singapore) — Empagliflozin leaflet, precautions section, surgery item (same page)","quote":"Plan to go for any surgery or procedure (you may need to stop the medication temporarily at least 72 hours before that)","accessed":"2026-08-27"},{"id":"healthhub_empa_pause","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/empagliflozin","label":"HealthHub (MOH Singapore) — Empagliflozin leaflet, 'When to temporarily stop Empagliflozin?' section (same page)","quote":"When feeling unwell eg. high fever, loss of appetite, diarrhoea, vomiting or at risk of dehydration … Surgical or dental procedure … A weight loss diet plan involving very low carbohydrate intake … Endurance physical activities … Fasting during Ramadan","accessed":"2026-08-27"},{"id":"healthhub_empa_int","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/empagliflozin","label":"HealthHub (MOH Singapore) — Empagliflozin leaflet, food and medication interactions section (same page)","quote":"Avoid taking alcohol with this medication as it may cause symptoms such as flushing, nausea, vomiting, headache, fast heartbeat, fast breathing, and giddiness.","accessed":"2026-08-27"},{"id":"fda_jardiance","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1782b947-4a72-4feb-a488-1469d9af82bd","label":"DailyMed / FDA prescribing information (SPL) — JARDIANCE (empagliflozin) tablets, Dosage and Administration; label effective 3 May 2023, retrieved via the openFDA drug-label API","quote":"The recommended dose of JARDIANCE is 10 mg once daily in the morning, taken with or without food … For additional glycemic control, dose may be increased to 25 mg in patients tolerating JARDIANCE","accessed":"2026-08-27"},{"id":"hsa_register_empa","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset d_767279312753558cbf19d48344577084, full 5,511-row dump pulled 27 Aug 26 and filtered locally; 10 empagliflozin rows, 4 of them empagliflozin alone)","quote":"JARDIANCE FILM-COATED TABLETS 10MG · Prescription Only — JARDIANCE FILM-COATED TABLET 25MG · Prescription Only — EMPAZOX 10 Empagliflozin Film Coated Tablets 10 mg · Prescription Only — JARDIANCE DUO 12.5MG/1000MG · Prescription Only — GLYXAMBI 25 MG/5 MG · Prescription Only","accessed":"2026-08-27"},{"id":"hsa_reclass","url":"https://www.hsa.gov.sg/therapeutic-products/registration-of-therapeutic-products/variation-application/reclassification/list-of-reclassified-medicines/","label":"HSA — forensic classification definitions used by the register (Prescription Only Medicine / Pharmacy Only / General Sale List)","quote":"Prescription-Only Medicine (POM): … can only be obtained from a doctor or from a pharmacist with a valid prescription","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:18.585742+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}