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Eggshell membrane

Supplement joint compound bone & joint
Aka: NEM, natural eggshell membrane
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Knee pain and function · manufacturer-funded trials
Studied for
One trial ran 60 days of daily use
Pros & cons
Pros
  • Pooled womac pain and function improved vs placebo
  • Trial doses ran 300–500 mg a day
  • 500 mg a day was the most common dose
Cons
  • All four pooled trials were manufacturer-funded
  • HSA's numeric limits cover vitamins/minerals only
Sources
  1. Efficacy of Eggshell Membrane in Knee Osteoarthritis: A Systematic Review and Meta-Analysis (García-Muñoz et al., Nutrients 2024) · read 2026-08-27
    what it says
    “ESM, a thin layer located between the calcified shell and the egg white … ESM significantly reduced pain and improved functionality … all four studies used in the meta-analysis were sponsored by the manufacturers”
  2. García-Muñoz et al., Nutrients 2024 — same review, included-trial characteristics table · read 2026-08-27
    what it says
    “Ruff et al. (2009) … 500 mg 60 days … Three studies administered a dosage of 500 mg … Two other studies used a dosage of 450 mg … one study used a dosage of 300 mg”
  3. HSA — Health Supplements Guidelines (Jan 2026), Tables 4–5 vitamin and mineral limits · read 2026-08-27
    what it says
    “HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.”
  4. HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines (Oct 2025) · read 2026-08-27
    what it says
    “The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.