{"ok":true,"entry":{"slug":"eggshell-membrane","kind":"supplement","name":"eggshell membrane","aliases":["NEM","natural eggshell membrane"],"brands_sg":[],"class":"joint compound","tags":["bone-joint"],"use_for":"knee pain and function · manufacturer-funded trials","use_after":null,"use_duration":"one trial ran 60 days of daily use","take_with":null,"pros":["pooled womac pain and function improved vs placebo","trial doses ran 300–500 mg a day","500 mg a day was the most common dose"],"cons":["all four pooled trials were manufacturer-funded","hsa's numeric limits cover vitamins/minerals only"],"dose_note":"trials used 300–500 mg a day; 500 mg was the most common, over runs of about 60 days","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["egg allergy — it is the membrane inside an eggshell","not on hsa's prohibited/restricted lists — which are not exhaustive"],"clashes":[],"sources":[{"id":"garcia2024","url":"https://europepmc.org/article/PMC/PMC11356944","label":"Efficacy of Eggshell Membrane in Knee Osteoarthritis: A Systematic Review and Meta-Analysis (García-Muñoz et al., Nutrients 2024)","quote":"ESM, a thin layer located between the calcified shell and the egg white … ESM significantly reduced pain and improved functionality … all four studies used in the meta-analysis were sponsored by the manufacturers","accessed":"2026-08-27"},{"id":"garcia2024b","url":"https://europepmc.org/article/PMC/PMC11356944","label":"García-Muñoz et al., Nutrients 2024 — same review, included-trial characteristics table","quote":"Ruff et al. (2009) … 500 mg 60 days … Three studies administered a dosage of 500 mg … Two other studies used a dosage of 450 mg … one study used a dosage of 300 mg","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (Jan 2026), Tables 4–5 vitamin and mineral limits","quote":"HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines (Oct 2025)","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:18.585742+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}