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Dydrogesterone

Medication progestogen hormonal
Aka: Duphaston
Brands seen in Singapore: Duphaston, Dydrogesterone Intega, Femoston, Femoston Conti
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Prescribed for period problems and as part of hrt
When to take
HealthHub: after food, at the SAMe time each day
Take with
Water · leaflet: with or without food, doses spread out
Pros & cons
Pros
  • HealthHub: a progestogen for irregular or heavy periods
  • Leaflet: hrt is described as 1 tablet a day for 14 days
  • Leaflet: extra tablets are unlikely to do any harm
Cons
  • Leaflet: unexpected bleeding or spotting can occur
  • HealthHub: nausea, breast tenderness, mood swings
  • Leaflet: hrt raises clot, stroke and breast-cancer risk
Sources
  1. HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows; cached at /tmp/hsa_all.json and filtered locally, not re-fetched) · read 2026-08-27
    what it says
    “All 5 registered dydrogesterone products read Forensicclassification 'Prescription Only' — SIN11255P DUPHASTON TABLET 10 mg · SIN17500P DYDROGESTERONE INTEGA 10MG · plus FEMOSTON 1/10, 2/10 and FEMOSTON CONTI 1/5 (dydrogesterone with estradiol)”
  2. HealthHub (Pharmaceutical Society of Singapore) — Dydrogesterone: what is this medication for · read 2026-08-27
    what it says
    “Dydrogesterone is a type of progestogen … Management of various abnormal uterine bleeding including absence of menstrual flow and heavy menstrual bleeding … Management of menopause in combination with estrogen replacement therapy”
  3. HealthHub — Dydrogesterone: how should I take or use this medication · read 2026-08-27
    what it says
    “This medicine should be taken after food … Take medication at the same time every day to avoid huge changes in the hormone levels in your body, which can lead to mood changes.”
  4. HealthHub — Dydrogesterone: common side effects · read 2026-08-27
    what it says
    “Stomach discomfort, nausea and vomiting. Take it after food to reduce these side effects. Breast tenderness. Headache … Dizziness, drowsiness … Weight changes, mood swings … Skin pigmentation.”
  5. HealthHub — Dydrogesterone: what precautions should I take · read 2026-08-27
    what it says
    “You have a history of or current medical conditions such as liver problems, stroke, heart disease, blood clots, migraine headaches, epilepsy (fits), diabetes mellitus or cancer.”
  6. Abbott package leaflet, Duphaston 10mg film-coated tablets (dydrogesterone), section 1 · read 2026-08-27
    what it says
    “Duphaston contains a medicine called 'dydrogesterone'. Dydrogesterone is a man-made hormone. It is very similar to the hormone 'progesterone' made by your body. Medicines like Duphaston are called 'progestogens'”
  7. Abbott package leaflet, Duphaston 10mg film-coated tablets, section 3 (Taking this medicine) · read 2026-08-27
    what it says
    “Swallow the tablet with water. You can take your tablet with or without food. If you have to take more than one tablet, spread them evenly over the day.”
  8. Abbott package leaflet, Duphaston 10mg film-coated tablets, section 3 (How much to take) · read 2026-08-27
    what it says
    “To relieve the symptoms of endometriosis • Take 2 to 3 tablets a day … For hormone replacement therapy (HRT) … Take 1 tablet a day … If necessary, your doctor may increase your dose to 2 tablets a day.”
  9. Abbott package leaflet, Duphaston 10mg film-coated tablets, section 2 (Do not take) · read 2026-08-27
    what it says
    “Do not take Duphaston if: you have a tumour that is made worse by progestogens (such as meningioma) … you have irregular or unusually heavy periods that your doctor does not already know about”
  10. Abbott package leaflet, Duphaston 10mg film-coated tablets, section 2 (Warnings and Precautions) · read 2026-08-27
    what it says
    “Check with your doctor or pharmacist before taking Duphaston if you have any of the following: depression, liver problems, a rare blood problem passed down in families (inherited) called 'porphyria'.”
  11. Abbott package leaflet, Duphaston 10mg film-coated tablets, section 2 (unexpected bleeding) · read 2026-08-27
    what it says
    “If you get unexpected vaginal bleeding or spotting it is usually nothing to worry about. It is especially likely during the first months of taking Duphaston.”
  12. Abbott package leaflet, Duphaston 10mg film-coated tablets, section 2 (HRT risks) · read 2026-08-27
    what it says
    “Taking estrogen-progesterone HRT and estrogen only HRT increases the risk of having a stroke … HRT increases the risk of blood clots in the veins (a deep vein thrombosis or DVT)”
  13. Abbott package leaflet, Duphaston 10mg film-coated tablets, section 3 (If you take more than you should) · read 2026-08-27
    what it says
    “If you (or someone else or a child) take too many Duphaston tablets, they are unlikely to do any harm. No treatment is necessary”
  14. Abbott package leaflet, Duphaston 10mg film-coated tablets, section 2 (Other medicines and Duphaston) · read 2026-08-27
    what it says
    “These medicines may lower the effect of Duphaston and lead to bleeding or spotting: medicines for fits (epilepsy) such as phenobarbital, phenytoin or carbamazepine … rifampicin, rifabutin, nevirapine, efavirenz … ritonavir or nelfinavir … St John's Wort”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.