{"ok":true,"entry":{"slug":"dydrogesterone","kind":"medication","name":"dydrogesterone","aliases":["Duphaston"],"brands_sg":["Duphaston","Dydrogesterone Intega","Femoston","Femoston Conti"],"class":"progestogen","tags":["hormonal"],"use_for":"prescribed for period problems and as part of hrt","use_after":"healthhub: after food, at the same time each day","use_duration":null,"take_with":"water · leaflet: with or without food, doses spread out","pros":["healthhub: a progestogen for irregular or heavy periods","leaflet: hrt is described as 1 tablet a day for 14 days","leaflet: extra tablets are unlikely to do any harm"],"cons":["leaflet: unexpected bleeding or spotting can occur","healthhub: nausea, breast tenderness, mood swings","leaflet: hrt raises clot, stroke and breast-cancer risk"],"dose_note":"the duphaston 10 mg film-coated tablet leaflet gives dosing by indication and no single overall ceiling; its highest stated daily amount is for endometriosis — 'Take 2 to 3 tablets a day', i.e. up to 30 mg a day — while for hrt it describes 1 tablet a day for fourteen days of the cycle, adding 'If necessary, your doctor may increase your dose to 2 tablets a day'. the sg register carries 10 mg tablets. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["a tumour made worse by progestogens, e.g. meningioma — leaflet: contraindicated","irregular or unusually heavy periods not yet assessed — leaflet: contraindicated","depression, liver problems or porphyria — leaflet: checked first","history of stroke, clots, heart disease, epilepsy, diabetes or cancer — healthhub"],"clashes":[{"src":["duph_inter"],"note":"leaflet: may lower the effect of duphaston and lead to bleeding or spotting","with":"epilepsy medicines (phenobarbital, phenytoin, carbamazepine)"},{"src":["duph_inter"],"note":"leaflet: may lower the effect of duphaston and lead to bleeding or spotting","with":"rifampicin, rifabutin, nevirapine, efavirenz"},{"src":["duph_inter"],"note":"leaflet: hiv medicines listed among those that may lower the effect of duphaston","with":"ritonavir, nelfinavir"},{"src":["duph_inter"],"note":"leaflet: herbal products listed among those that may lower the effect of duphaston","with":"st john's wort, sage or ginkgo biloba"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows; cached at /tmp/hsa_all.json and filtered locally, not re-fetched)","quote":"All 5 registered dydrogesterone products read Forensicclassification 'Prescription Only' — SIN11255P DUPHASTON TABLET 10 mg · SIN17500P DYDROGESTERONE INTEGA 10MG · plus FEMOSTON 1/10, 2/10 and FEMOSTON CONTI 1/5 (dydrogesterone with estradiol)","accessed":"2026-08-27"},{"id":"hh_dydro_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/dydrogesterone","label":"HealthHub (Pharmaceutical Society of Singapore) — Dydrogesterone: what is this medication for","quote":"Dydrogesterone is a type of progestogen … Management of various abnormal uterine bleeding including absence of menstrual flow and heavy menstrual bleeding … Management of menopause in combination with estrogen replacement therapy","accessed":"2026-08-27"},{"id":"hh_dydro_admin","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/dydrogesterone","label":"HealthHub — Dydrogesterone: how should I take or use this medication","quote":"This medicine should be taken after food … Take medication at the same time every day to avoid huge changes in the hormone levels in your body, which can lead to mood changes.","accessed":"2026-08-27"},{"id":"hh_dydro_se","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/dydrogesterone","label":"HealthHub — Dydrogesterone: common side effects","quote":"Stomach discomfort, nausea and vomiting. Take it after food to reduce these side effects. Breast tenderness. Headache … Dizziness, drowsiness … Weight changes, mood swings … Skin pigmentation.","accessed":"2026-08-27"},{"id":"hh_dydro_precautions","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/dydrogesterone","label":"HealthHub — Dydrogesterone: what precautions should I take","quote":"You have a history of or current medical conditions such as liver problems, stroke, heart disease, blood clots, migraine headaches, epilepsy (fits), diabetes mellitus or cancer.","accessed":"2026-08-27"},{"id":"duph_uses","url":"https://www.tusalud.abbott/wp-content/uploads/2023/12/duphaston-10mg.pdf","label":"Abbott package leaflet, Duphaston 10mg film-coated tablets (dydrogesterone), section 1","quote":"Duphaston contains a medicine called 'dydrogesterone'. Dydrogesterone is a man-made hormone. It is very similar to the hormone 'progesterone' made by your body. Medicines like Duphaston are called 'progestogens'","accessed":"2026-08-27"},{"id":"duph_admin","url":"https://www.tusalud.abbott/wp-content/uploads/2023/12/duphaston-10mg.pdf","label":"Abbott package leaflet, Duphaston 10mg film-coated tablets, section 3 (Taking this medicine)","quote":"Swallow the tablet with water. You can take your tablet with or without food. If you have to take more than one tablet, spread them evenly over the day.","accessed":"2026-08-27"},{"id":"duph_dose","url":"https://www.tusalud.abbott/wp-content/uploads/2023/12/duphaston-10mg.pdf","label":"Abbott package leaflet, Duphaston 10mg film-coated tablets, section 3 (How much to take)","quote":"To relieve the symptoms of endometriosis • Take 2 to 3 tablets a day … For hormone replacement therapy (HRT) … Take 1 tablet a day … If necessary, your doctor may increase your dose to 2 tablets a day.","accessed":"2026-08-27"},{"id":"duph_ci","url":"https://www.tusalud.abbott/wp-content/uploads/2023/12/duphaston-10mg.pdf","label":"Abbott package leaflet, Duphaston 10mg film-coated tablets, section 2 (Do not take)","quote":"Do not take Duphaston if: you have a tumour that is made worse by progestogens (such as meningioma) … you have irregular or unusually heavy periods that your doctor does not already know about","accessed":"2026-08-27"},{"id":"duph_warn","url":"https://www.tusalud.abbott/wp-content/uploads/2023/12/duphaston-10mg.pdf","label":"Abbott package leaflet, Duphaston 10mg film-coated tablets, section 2 (Warnings and Precautions)","quote":"Check with your doctor or pharmacist before taking Duphaston if you have any of the following: depression, liver problems, a rare blood problem passed down in families (inherited) called 'porphyria'.","accessed":"2026-08-27"},{"id":"duph_bleed","url":"https://www.tusalud.abbott/wp-content/uploads/2023/12/duphaston-10mg.pdf","label":"Abbott package leaflet, Duphaston 10mg film-coated tablets, section 2 (unexpected bleeding)","quote":"If you get unexpected vaginal bleeding or spotting it is usually nothing to worry about. It is especially likely during the first months of taking Duphaston.","accessed":"2026-08-27"},{"id":"duph_hrt","url":"https://www.tusalud.abbott/wp-content/uploads/2023/12/duphaston-10mg.pdf","label":"Abbott package leaflet, Duphaston 10mg film-coated tablets, section 2 (HRT risks)","quote":"Taking estrogen-progesterone HRT and estrogen only HRT increases the risk of having a stroke … HRT increases the risk of blood clots in the veins (a deep vein thrombosis or DVT)","accessed":"2026-08-27"},{"id":"duph_overdose","url":"https://www.tusalud.abbott/wp-content/uploads/2023/12/duphaston-10mg.pdf","label":"Abbott package leaflet, Duphaston 10mg film-coated tablets, section 3 (If you take more than you should)","quote":"If you (or someone else or a child) take too many Duphaston tablets, they are unlikely to do any harm. No treatment is necessary","accessed":"2026-08-27"},{"id":"duph_inter","url":"https://www.tusalud.abbott/wp-content/uploads/2023/12/duphaston-10mg.pdf","label":"Abbott package leaflet, Duphaston 10mg film-coated tablets, section 2 (Other medicines and Duphaston)","quote":"These medicines may lower the effect of Duphaston and lead to bleeding or spotting: medicines for fits (epilepsy) such as phenobarbital, phenytoin or carbamazepine … rifampicin, rifabutin, nevirapine, efavirenz … ritonavir or nelfinavir … St John's Wort","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:18.585742+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}