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Digestive enzymes

Supplement enzyme blend gut
Aka: amylase, lipase, protease, Super Enzymes, Digest Basic
Brands seen in Singapore: California Gold Nutrition, NOW Foods, Enzymedica, Doctor's Best, 21st Century
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Lactose intolerance · dyspepsia symptoms in small trials
When to take
The lactase trial dosed 5 minutes before a lactose load
Take with
The dairy or meal the enzyme is meant to digest
Pros & cons
Pros
  • Lactase cut breath hydrogen 55% over 180 min
  • Symptom scores fell in 47 lactose-intolerant adults
  • Multi-enzyme blend eased dyspepsia scores in 120 adults
Cons
  • Limited human evidence — small, single-centre trials
  • Lactase data are for confirmed lactose intolerance
  • The dyspepsia trial ran 2 months, ages 18 to 59 only
Sources
  1. Effect of lactase on symptoms and hydrogen breath levels in lactose intolerance: a crossover placebo-controlled study (JGH Open, 2021; PMID 33490624) · read 2026-08-27
    what it says
    “patients in group A consumed three chewable lactase 4500 FCC tablets 5 min before the 25-g lactose load … Reduction in cumulative hydrogen breath level over 180 min was 55% when patients received lactase compared to placebo”
  2. Effect of lactase on symptoms and hydrogen breath levels in lactose intolerance (JGH Open, 2021) — Introduction and Results · read 2026-08-27
    what it says
    “it is therefore logical to coadminister lactase enzyme along with milk/dairy products … Forty-seven patients … with lactose intolerance formed the study group. Clinical symptoms, mean clinical score … were improved when the patients were given lactase”
  3. Efficacy of digestive enzyme supplementation in functional dyspepsia: a monocentric, randomized, double-blind, placebo-controlled clinical trial (Biomed Pharmacother, 2023; PMID 37976892) · read 2026-08-27
    what it says
    “Enrolled subjects (n = 120 …), aged 18-59 years, were randomized … to receive either 2 capsules per day of the food supplement (containing 200 mg of the multi-enzyme blend/capsule) or placebo, for 2 months”
  4. HSA — Health Supplements Guidelines GL-CHPB-3-001 Rev. 020 (January 2026), s3 working definition + clause 4.8 (Tables 4–5 cover vitamins and minerals only) · read 2026-08-27
    what it says
    “a. Vitamins, minerals, amino acids, fatty acids, enzymes, probiotics and other bioactive substances … 4.8 HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5”
  5. HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. 001 (October 2025), clause 1.3 + Annex A/B · read 2026-08-27
    what it says
    “The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list [no amylase, lipase, protease or other digestive-enzyme row in Annex A or B]”
  6. iHerb Singapore — 'Digestive Enzymes' category page (Gut Health), default order, 421 results · read 2026-08-27
    what it says
    “California Gold Nutrition, SimplyOne®, Complete Enzymes with Betaine HCl … NOW Foods, Super Enzymes, 90 Capsules … Enzymedica, Digest Basic®, 180 Capsules … Doctor's Best, Digestive Enzymes … 21st Century, Chewable Papaya Enzyme”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.