{"ok":true,"entry":{"slug":"digestive-enzymes","kind":"supplement","name":"digestive enzymes","aliases":["amylase","lipase","protease","Super Enzymes","Digest Basic"],"brands_sg":["California Gold Nutrition","NOW Foods","Enzymedica","Doctor's Best","21st Century"],"class":"enzyme blend","tags":["gut"],"use_for":"lactose intolerance · dyspepsia symptoms in small trials","use_after":"the lactase trial dosed 5 minutes before a lactose load","use_duration":null,"take_with":"the dairy or meal the enzyme is meant to digest","pros":["lactase cut breath hydrogen 55% over 180 min","symptom scores fell in 47 lactose-intolerant adults","multi-enzyme blend eased dyspepsia scores in 120 adults"],"cons":["limited human evidence — small, single-centre trials","lactase data are for confirmed lactose intolerance","the dyspepsia trial ran 2 months, ages 18 to 59 only"],"dose_note":"the lactase trial used three chewable 4,500 fcc tablets taken 5 minutes before a 25 g lactose load, in 47 adults whose lactose intolerance had been confirmed by hydrogen breath test; the functional dyspepsia trial used 2 capsules a day, each holding 200 mg of a multi-enzyme blend from fungal fermentation, for 2 months in 120 adults aged 18–59; enzyme activity is labelled in fcc units, not milligrams, so mg on a label says nothing about strength; hsa counts enzymes as health supplements but sets no daily limit for them, and no enzyme appears on the october 2025 prohibited/restricted annexes; no rda, ul or fda daily value exists","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["lactose intolerance was confirmed by hydrogen breath test before lactase was trialled","persistent upper-gut symptoms — the dyspepsia trial enrolled people already clinically assessed","no trial data read here run beyond 2 months, or outside ages 18 to 59"],"clashes":[],"sources":[{"id":"lactase2021","url":"https://europepmc.org/article/PMC/PMC7812489","label":"Effect of lactase on symptoms and hydrogen breath levels in lactose intolerance: a crossover placebo-controlled study (JGH Open, 2021; PMID 33490624)","quote":"patients in group A consumed three chewable lactase 4500 FCC tablets 5 min before the 25-g lactose load … Reduction in cumulative hydrogen breath level over 180 min was 55% when patients received lactase compared to placebo","accessed":"2026-08-27"},{"id":"lactase2021_rationale","url":"https://europepmc.org/article/PMC/PMC7812489","label":"Effect of lactase on symptoms and hydrogen breath levels in lactose intolerance (JGH Open, 2021) — Introduction and Results","quote":"it is therefore logical to coadminister lactase enzyme along with milk/dairy products … Forty-seven patients … with lactose intolerance formed the study group. Clinical symptoms, mean clinical score … were improved when the patients were given lactase","accessed":"2026-08-27"},{"id":"enzymes_dyspepsia2023","url":"https://europepmc.org/article/MED/37976892","label":"Efficacy of digestive enzyme supplementation in functional dyspepsia: a monocentric, randomized, double-blind, placebo-controlled clinical trial (Biomed Pharmacother, 2023; PMID 37976892)","quote":"Enrolled subjects (n = 120 …), aged 18-59 years, were randomized … to receive either 2 capsules per day of the food supplement (containing 200 mg of the multi-enzyme blend/capsule) or placebo, for 2 months","accessed":"2026-08-27"},{"id":"hsa_hs_guidelines","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines GL-CHPB-3-001 Rev. 020 (January 2026), s3 working definition + clause 4.8 (Tables 4–5 cover vitamins and minerals only)","quote":"a. Vitamins, minerals, amino acids, fatty acids, enzymes, probiotics and other bioactive substances … 4.8 HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5","accessed":"2026-08-27"},{"id":"hsa_prohibited_2025","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. 001 (October 2025), clause 1.3 + Annex A/B","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list [no amylase, lipase, protease or other digestive-enzyme row in Annex A or B]","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/digestive-enzymes","label":"iHerb Singapore — 'Digestive Enzymes' category page (Gut Health), default order, 421 results","quote":"California Gold Nutrition, SimplyOne®, Complete Enzymes with Betaine HCl … NOW Foods, Super Enzymes, 90 Capsules … Enzymedica, Digest Basic®, 180 Capsules … Doctor's Best, Digestive Enzymes … 21st Century, Chewable Papaya Enzyme","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:18.585742+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}