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Devil's claw

Supplement botanical bone & joint
Aka: Harpagophytum procumbens
Brands seen in Singapore: Swanson Vitamins, NOW Foods, Nutricost, Solaray, Nature's Way
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Musculoskeletal pain — osteoarthritis and low back pain
Pros & cons
Pros
  • Some trials show symptom relief in osteoarthritis
  • Preparations commonly give 50–60 mg harpagoside a day
Cons
  • Few clinical studies and no long-term studies
  • Poor methodological quality in the studies reviewed
  • Stomach or duodenal ulcers are a contraindication
Sources
  1. Harpagophytum procumbens in musculoskeletal disorders: current evidence and comparison with NSAIDs (Frontiers in Pharmacology 2026) · read 2026-08-27
    what it says
    “Clinical studies, mainly in osteoarthritis and low back pain, suggest that selected HP preparations may provide symptomatic benefit in some patients … commonly used preparations providing approximately 50–60 mg/day of harpagoside”
  2. Devil's claw (Harpagophytum procumbens): is the buzz in Google justified? (Naunyn-Schmiedeberg's Archives of Pharmacology 2025) — analysis of 88 products · read 2026-08-27
    what it says
    “The study analysis also revealed a limited number of clinical studies, no long-term studies, and poor methodological quality, undermining their reliability … The bitter substances HP contains … can lead to gastroduodenal ulcers, which is why they are considered a contraindication”
  3. HSA — Guidelines on health supplements (Singapore), maximum daily limits Tables 4–5 · read 2026-08-27
    what it says
    “Table 4: Vitamins Limits … Nutrient Maximum Daily Limit … Table 5: Minerals Limits”
  4. HSA — Guidelines on prohibited and restricted ingredients in health supplements and traditional medicines (Oct 2025), Annex A/B · read 2026-08-27
    what it says
    “The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.”
  5. iHerb Singapore — Devil's Claw: Root Capsules for Joint & Back Comfort category page (default best-selling order) · read 2026-08-27
    what it says
    “Devil's Claw: Root Capsules for Joint & Back Comfort”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.