{"ok":true,"entry":{"slug":"devils-claw","kind":"supplement","name":"devil's claw","aliases":["Harpagophytum procumbens"],"brands_sg":["Swanson Vitamins","NOW Foods","Nutricost","Solaray","Nature's Way"],"class":"botanical","tags":["bone-joint"],"use_for":"musculoskeletal pain — osteoarthritis and low back pain","use_after":null,"use_duration":null,"take_with":null,"pros":["some trials show symptom relief in osteoarthritis","preparations commonly give 50–60 mg harpagoside a day"],"cons":["few clinical studies and no long-term studies","poor methodological quality in the studies reviewed","stomach or duodenal ulcers are a contraindication"],"dose_note":"commonly used preparations provide about 50–60 mg of harpagoside a day","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["gastroduodenal ulcers — named as a contraindication because devil's claw bitters stimulate stomach acid","supplement labels often carry no contraindication information at all"],"clashes":[],"sources":[{"id":"hp_review2026","url":"https://europepmc.org/article/PMC/PMC13323821","label":"Harpagophytum procumbens in musculoskeletal disorders: current evidence and comparison with NSAIDs (Frontiers in Pharmacology 2026)","quote":"Clinical studies, mainly in osteoarthritis and low back pain, suggest that selected HP preparations may provide symptomatic benefit in some patients … commonly used preparations providing approximately 50–60 mg/day of harpagoside","accessed":"2026-08-27"},{"id":"hp_products2025","url":"https://europepmc.org/article/PMC/PMC12350520","label":"Devil's claw (Harpagophytum procumbens): is the buzz in Google justified? (Naunyn-Schmiedeberg's Archives of Pharmacology 2025) — analysis of 88 products","quote":"The study analysis also revealed a limited number of clinical studies, no long-term studies, and poor methodological quality, undermining their reliability … The bitter substances HP contains … can lead to gastroduodenal ulcers, which is why they are considered a contraindication","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Guidelines on health supplements (Singapore), maximum daily limits Tables 4–5","quote":"Table 4: Vitamins Limits … Nutrient Maximum Daily Limit … Table 5: Minerals Limits","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on prohibited and restricted ingredients in health supplements and traditional medicines (Oct 2025), Annex A/B","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/devils-claw","label":"iHerb Singapore — Devil's Claw: Root Capsules for Joint & Back Comfort category page (default best-selling order)","quote":"Devil's Claw: Root Capsules for Joint & Back Comfort","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:18.585742+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}