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D-mannose

Supplement sugar women's health
Aka: mannose
Brands seen in Singapore: NOW Foods, Nutricost, MRM Nutrition, Nature's Answer, Nature's Craft
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Unclear — pooled RCT data on recurrent UTI is null
Take with
Sold with cranberry in SG · that pair not separately pooled
Studied for
The placebo-controlled trial ran 6 months of daily use
Pros & cons
Pros
  • Well tolerated across trials — mild, infrequent effects
  • Human RCTS exist — 6 pooled, 1,167 participants
  • The dose is settled — trials used 2 g a day
Cons
  • Pooled RCTS: no drop in recurrent UTI vs control
  • Reviews call the evidence conflicting, heterogeneous
  • No benefit found in postmenopausal women either
Sources
  1. d-Mannose for Prevention of Recurrent Urinary Tract Infection Among Women: A Randomized Clinical Trial (MERIT; JAMA Internal Medicine 2024; PMID 38587819) · read 2026-08-27
    what it says
    “To determine whether d-mannose taken for 6 months reduces the proportion of women with recurrent UTI experiencing a medically attended UTI … Two grams daily of d-mannose powder or matched volume of placebo powder”
  2. MERIT trial, JAMA Internal Medicine 2024 — participants randomised · read 2026-08-27
    what it says
    “Of 598 women eligible (mean [range] age, 58 [18-93] years), 303 were randomized to d-mannose (50.7%) and 295 to placebo (49.3%)”
  3. Efficacy of D-Mannose Monotherapy vs. Other Agents in Preventing Recurrent Urinary Tract Infections in Women: A Systematic Review and Meta-Analysis (Urology Research & Practice 2026; PMC13034003) · read 2026-08-27
    what it says
    “A meta-analysis of 3 eligible studies comparing D-mannose to placebo/control (n = 831) demonstrated a non-significant reduction in rUTIs … The largest and highest quality study showed no significant difference between D-mannose and placebo”
  4. Urology Research & Practice 2026 meta-analysis — tolerability and overall recommendation · read 2026-08-27
    what it says
    “Across all included studies, D-mannose appears to be well tolerated, with only mild and infrequent side effects … the current evidence does not support its routine use in the prevention of recurrent urinary tract infections”
  5. Efficacy of D-mannose as prophylaxis of recurrent urinary tract infection: a systematic review and meta-analysis of randomized controlled trials (Jornal Brasileiro de Nefrologia 2025; PMC12471090) · read 2026-08-27
    what it says
    “We included 6 RCTs comprising 1,167 participants … D-mannose was not associated with a reduction in recurrent UTI compared with control (RR: 0.57, 95% CI 0.29 - 1.15) … did not improve outcomes in a subgroup of postmenopausal women”
  6. D-Mannose for prevention of recurrent urinary tract infection in adult women: an updated systematic review and meta-analysis of RCTs (Journal of Infection Prevention 2025; PMID 41195062) · read 2026-08-27
    what it says
    “The systematic review identified 4 randomized controlled trials (RCTs) including 890 participants … Recurrent UTI (RR 0.44; 95% CI 0.18-1.11; p = .082; I2 = 90%) … did not differ significantly between the groups”
  7. Journal of Infection Prevention 2025 meta-analysis — state of the evidence · read 2026-08-27
    what it says
    “Several randomized controlled trials have explored the efficacy and safety of D-mannose for the prevention of UTI in adult women but reported conflicting results … heterogeneity in the results make it difficult to draw conclusions”
  8. Randomized clinical trial of non-antibiotic prophylaxis with d-Mannose plus Proanthocyanidins vs. Proanthocyanidins alone in de novo kidney transplant recipients (Manotras study; Nefrologia 2024; PMID 38637262) · read 2026-08-27
    what it says
    “Non-antibiotic therapy is an unmet need to prevent UTI after kidney transplantation; however, the use of d-Mannose plus PAC does not seem capable to prevent it”
  9. HSA Singapore - Guidelines on Prohibited and Restricted Ingredients in HS and TM, GL-CHPB-1-012 Rev. No. 001 (October 2025), clause 1.3 + Annexes A and B · read 2026-08-27
    what it says
    “The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list”
  10. iHerb Singapore — D-Mannose category (Women's Health), default order · read 2026-08-27
    what it says
    “D-Mannose … 1 - 48 of 50 results … NOW Foods, D-Mannose, 500 mg … Nutricost, D-Mannose, 120 Capsules … MRM Nutrition, D-Mannose + Cranberry … Nature's Answer, UT Answer®, D-Mannose & Cranberry Concentrate … Nature's Craft, D-Mannose & Cranberry”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.