{"ok":true,"entry":{"slug":"d-mannose","kind":"supplement","name":"d-mannose","aliases":["mannose"],"brands_sg":["NOW Foods","Nutricost","MRM Nutrition","Nature's Answer","Nature's Craft"],"class":"sugar","tags":["womens-health"],"use_for":"unclear — pooled rct data on recurrent uti is null","use_after":null,"use_duration":"the placebo-controlled trial ran 6 months of daily use","take_with":"sold with cranberry in sg · that pair not separately pooled","pros":["well tolerated across trials — mild, infrequent effects","human rcts exist — 6 pooled, 1,167 participants","the dose is settled — trials used 2 g a day"],"cons":["pooled rcts: no drop in recurrent uti vs control","reviews call the evidence conflicting, heterogeneous","no benefit found in postmenopausal women either"],"dose_note":"the largest placebo-controlled trial gave 2 g of d-mannose powder daily for 6 months to 598 women recruited in uk primary care, and the 2026 review records that this largest, highest-quality study showed no significant difference against placebo; the 2025 and 2026 meta-analyses pooling 4 to 6 rcts (890 to 1,167 participants) likewise found no significant reduction in recurrent uti against control or antibiotics, with heterogeneity of 90% and above","dosage":{"ul":null,"unit":"g","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"adult women with recurrent uti — the population the trials enrolled","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["prevention is what was tested, not treatment of an active uti","outside adult women — the pooled rcts did not enrol other groups","kidney transplant — a mannose plus cranberry trial found no benefit","d-mannose is not listed in hsa annex a or b — hsa says that list is not exhaustive"],"clashes":[],"sources":[{"id":"merit2024","url":"https://europepmc.org/article/MED/38587819","label":"d-Mannose for Prevention of Recurrent Urinary Tract Infection Among Women: A Randomized Clinical Trial (MERIT; JAMA Internal Medicine 2024; PMID 38587819)","quote":"To determine whether d-mannose taken for 6 months reduces the proportion of women with recurrent UTI experiencing a medically attended UTI … Two grams daily of d-mannose powder or matched volume of placebo powder","accessed":"2026-08-27"},{"id":"merit2024_n","url":"https://europepmc.org/article/MED/38587819","label":"MERIT trial, JAMA Internal Medicine 2024 — participants randomised","quote":"Of 598 women eligible (mean [range] age, 58 [18-93] years), 303 were randomized to d-mannose (50.7%) and 295 to placebo (49.3%)","accessed":"2026-08-27"},{"id":"urp2026","url":"https://europepmc.org/article/PMC/PMC13034003","label":"Efficacy of D-Mannose Monotherapy vs. Other Agents in Preventing Recurrent Urinary Tract Infections in Women: A Systematic Review and Meta-Analysis (Urology Research & Practice 2026; PMC13034003)","quote":"A meta-analysis of 3 eligible studies comparing D-mannose to placebo/control (n = 831) demonstrated a non-significant reduction in rUTIs … The largest and highest quality study showed no significant difference between D-mannose and placebo","accessed":"2026-08-27"},{"id":"urp2026_safety","url":"https://europepmc.org/article/PMC/PMC13034003","label":"Urology Research & Practice 2026 meta-analysis — tolerability and overall recommendation","quote":"Across all included studies, D-mannose appears to be well tolerated, with only mild and infrequent side effects … the current evidence does not support its routine use in the prevention of recurrent urinary tract infections","accessed":"2026-08-27"},{"id":"jbn2025","url":"https://europepmc.org/article/PMC/PMC12471090","label":"Efficacy of D-mannose as prophylaxis of recurrent urinary tract infection: a systematic review and meta-analysis of randomized controlled trials (Jornal Brasileiro de Nefrologia 2025; PMC12471090)","quote":"We included 6 RCTs comprising 1,167 participants … D-mannose was not associated with a reduction in recurrent UTI compared with control (RR: 0.57, 95% CI 0.29 - 1.15) … did not improve outcomes in a subgroup of postmenopausal women","accessed":"2026-08-27"},{"id":"jip2025","url":"https://europepmc.org/article/MED/41195062","label":"D-Mannose for prevention of recurrent urinary tract infection in adult women: an updated systematic review and meta-analysis of RCTs (Journal of Infection Prevention 2025; PMID 41195062)","quote":"The systematic review identified 4 randomized controlled trials (RCTs) including 890 participants … Recurrent UTI (RR 0.44; 95% CI 0.18-1.11; p = .082; I2 = 90%) … did not differ significantly between the groups","accessed":"2026-08-27"},{"id":"jip2025_conflict","url":"https://europepmc.org/article/MED/41195062","label":"Journal of Infection Prevention 2025 meta-analysis — state of the evidence","quote":"Several randomized controlled trials have explored the efficacy and safety of D-mannose for the prevention of UTI in adult women but reported conflicting results … heterogeneity in the results make it difficult to draw conclusions","accessed":"2026-08-27"},{"id":"manotras2024","url":"https://europepmc.org/article/MED/38637262","label":"Randomized clinical trial of non-antibiotic prophylaxis with d-Mannose plus Proanthocyanidins vs. Proanthocyanidins alone in de novo kidney transplant recipients (Manotras study; Nefrologia 2024; PMID 38637262)","quote":"Non-antibiotic therapy is an unmet need to prevent UTI after kidney transplantation; however, the use of d-Mannose plus PAC does not seem capable to prevent it","accessed":"2026-08-27"},{"id":"hsa_prohibited_2025","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA Singapore - Guidelines on Prohibited and Restricted Ingredients in HS and TM, GL-CHPB-1-012 Rev. No. 001 (October 2025), clause 1.3 + Annexes A and B","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/d-mannose","label":"iHerb Singapore — D-Mannose category (Women's Health), default order","quote":"D-Mannose … 1 - 48 of 50 results … NOW Foods, D-Mannose, 500 mg … Nutricost, D-Mannose, 120 Capsules … MRM Nutrition, D-Mannose + Cranberry … Nature's Answer, UT Answer®, D-Mannose & Cranberry Concentrate … Nature's Craft, D-Mannose & Cranberry","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:16.693643+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}