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Collagen

Supplement protein skin & hairbone & joint
Aka: collagen peptides, hydrolyzed collagen, marine collagen
Brands seen in Singapore: California Gold Nutrition, Vital Proteins, NOW Foods, Youtheory, NeoCell
Third-party tested: Vital Proteins lists a certified collagen product with NSF Certified for Sport.Certification is granted per product, so check the tub you actually own. Not being listed is not the same as failing.
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Skin hydration and elasticity · knee joint pain (4 trials)
When to take
Daily
Take with
Any drink · one knee trial used 10 g in a liquid of choice
Studied for
Skin trials ran 2–12 weeks, more effect past 8
Pros & cons
Pros
  • 26 skin trials: more hydration, elasticity vs placebo
  • 4 knee trials (n=507): less pain than placebo
  • Effect on skin larger past 8 weeks of daily use
Cons
  • Skin trials only 2–12 weeks · several biases found
  • Knee trials: high risk of bias · weak side-effect data
  • Gut upset the most common side effect in knee trials
Sources
  1. Effects of oral collagen for skin anti-aging: a systematic review and meta-analysis (Pu et al., Nutrients 2023) · read 2026-08-27
    what it says
    “26 randomized controlled trials (RCTs) involving 1721 patients … significantly improved skin hydration … and elasticity … compared to the placebo group … several biases in the included RCTs”
  2. Pu et al., Nutrients 2023 — collagen sources across included trials · read 2026-08-27
    what it says
    “14 focused on collagens extracted from fish, one … bovine, one … chicken, two … porcine”
  3. Pu et al., Nutrients 2023 — duration subgroup and Table 1 doses · read 2026-08-27
    what it says
    “ranged from 2 to 12 weeks … long-term use (>8 weeks) of HC … were more favorable than … short-term use (<8 weeks) … 2.5 g HC/5 g HC (porcine) … 3 g HC (fish) … 10 g HC”
  4. Analgesic efficacy of collagen peptide in knee osteoarthritis: a meta-analysis of randomized controlled trials (Lin et al., J Orthop Surg Res 2023) · read 2026-08-27
    what it says
    “Four trials involving 507 patients with knee osteoarthritis … All these trials were considered to have a high risk of bias … a significant difference in pain relief”
  5. Lin et al., J Orthop Surg Res 2023 — adverse events and GRADE quality · read 2026-08-27
    what it says
    “no significant difference in the risk of adverse events … quality of evidence: very low”
  6. Lin et al., J Orthop Surg Res 2023 — Table 1 regimens · read 2026-08-27
    what it says
    “Peptan B 2000 of bovine origin,8 g per day for 6 months … 10 g hydrolyzed collagen for once-daily administration dissolved in a liquid of the patient's choice … 2.0 g of hydrolyzed collagen type II”
  7. Lin et al., J Orthop Surg Res 2023 — adverse-event discussion · read 2026-08-27
    what it says
    “the most common adverse event of collagen peptide was gastrointestinal disorders (n = 29), followed by migraine headache (n = 14) and respiratory infection (n = 10). However, none of the adverse events were obviously associated with the treatment”
  8. HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev 001 (Oct 2025) · read 2026-08-27
    what it says
    “The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list [collagen / collagen peptides not listed in Annex A or B]”
  9. iHerb Singapore — Collagen Supplements category (SG$ pricing, default order) · read 2026-08-27
    what it says
    “California Gold Nutrition, CollagenUP®, Hydrolyzed Marine Collagen Peptides … Vital Proteins, Collagen Peptides, Unflavored … NOW Foods, UC-II®, Joint Health with Undenatured Type II Collagen … Youtheory, Collagen, 290 Tablets … NeoCell, Grassfed Collagen Peptides + Vitamin C & Biotin”
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Updated 2026-08-30. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.