{"ok":true,"entry":{"slug":"collagen","kind":"supplement","name":"collagen","aliases":["collagen peptides","hydrolyzed collagen","marine collagen"],"brands_sg":["California Gold Nutrition","Vital Proteins","NOW Foods","Youtheory","NeoCell"],"class":"protein","tags":["skin-hair","bone-joint"],"use_for":"skin hydration and elasticity · knee joint pain (4 trials)","use_after":"daily","use_duration":"skin trials ran 2–12 weeks, more effect past 8","take_with":"any drink · one knee trial used 10 g in a liquid of choice","pros":["26 skin trials: more hydration, elasticity vs placebo","4 knee trials (n=507): less pain than placebo","effect on skin larger past 8 weeks of daily use"],"cons":["skin trials only 2–12 weeks · several biases found","knee trials: high risk of bias · weak side-effect data","gut upset the most common side effect in knee trials"],"dose_note":"skin trials use about 2.5–10 g a day of hydrolysed collagen for 2–12 weeks, with more effect past 8 weeks; knee trials use 2–10 g a day for up to 6 months; uc-ii (undenatured type ii) is a different, low-dose product not covered by these reviews","dosage":{"ul":null,"unit":"g","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["fish, cattle, pig or chicken sourced — allergy or diet rules?","pregnant, breastfeeding or under 18 — not studied in these reviews"],"clashes":[],"sources":[{"id":"pu2023","url":"https://europepmc.org/article/PMC/PMC10180699","label":"Effects of oral collagen for skin anti-aging: a systematic review and meta-analysis (Pu et al., Nutrients 2023)","quote":"26 randomized controlled trials (RCTs) involving 1721 patients … significantly improved skin hydration … and elasticity … compared to the placebo group … several biases in the included RCTs","accessed":"2026-08-27"},{"id":"pu2023_source","url":"https://europepmc.org/article/PMC/PMC10180699","label":"Pu et al., Nutrients 2023 — collagen sources across included trials","quote":"14 focused on collagens extracted from fish, one … bovine, one … chicken, two … porcine","accessed":"2026-08-27"},{"id":"pu2023_dose","url":"https://europepmc.org/article/PMC/PMC10180699","label":"Pu et al., Nutrients 2023 — duration subgroup and Table 1 doses","quote":"ranged from 2 to 12 weeks … long-term use (>8 weeks) of HC … were more favorable than … short-term use (<8 weeks) … 2.5 g HC/5 g HC (porcine) … 3 g HC (fish) … 10 g HC","accessed":"2026-08-27"},{"id":"lin2023","url":"https://europepmc.org/article/PMC/PMC10505327","label":"Analgesic efficacy of collagen peptide in knee osteoarthritis: a meta-analysis of randomized controlled trials (Lin et al., J Orthop Surg Res 2023)","quote":"Four trials involving 507 patients with knee osteoarthritis … All these trials were considered to have a high risk of bias … a significant difference in pain relief","accessed":"2026-08-27"},{"id":"lin2023_quality","url":"https://europepmc.org/article/PMC/PMC10505327","label":"Lin et al., J Orthop Surg Res 2023 — adverse events and GRADE quality","quote":"no significant difference in the risk of adverse events … quality of evidence: very low","accessed":"2026-08-27"},{"id":"lin2023_dose","url":"https://europepmc.org/article/PMC/PMC10505327","label":"Lin et al., J Orthop Surg Res 2023 — Table 1 regimens","quote":"Peptan B 2000 of bovine origin,8 g per day for 6 months … 10 g hydrolyzed collagen for once-daily administration dissolved in a liquid of the patient's choice … 2.0 g of hydrolyzed collagen type II","accessed":"2026-08-27"},{"id":"lin2023_ae","url":"https://europepmc.org/article/PMC/PMC10505327","label":"Lin et al., J Orthop Surg Res 2023 — adverse-event discussion","quote":"the most common adverse event of collagen peptide was gastrointestinal disorders (n = 29), followed by migraine headache (n = 14) and respiratory infection (n = 10). However, none of the adverse events were obviously associated with the treatment","accessed":"2026-08-27"},{"id":"hsa_prohibited_2025","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev 001 (Oct 2025)","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list [collagen / collagen peptides not listed in Annex A or B]","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/collagen-supplements","label":"iHerb Singapore — Collagen Supplements category (SG$ pricing, default order)","quote":"California Gold Nutrition, CollagenUP®, Hydrolyzed Marine Collagen Peptides … Vital Proteins, Collagen Peptides, Unflavored … NOW Foods, UC-II®, Joint Health with Undenatured Type II Collagen … Youtheory, Collagen, 290 Tablets … NeoCell, Grassfed Collagen Peptides + Vitamin C & Biotin","accessed":"2026-08-27"}],"brand_certs":[{"brand":"Vital Proteins","example":"Vital Proteins® Advanced Collagen Peptides + Vitamin C + Zinc","programme":"NSF Certified for Sport","matching_products":5,"brand_total_certified":9}],"updated_at":"2026-08-30T17:59:36.026222+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}