← All medications

Co-amoxiclav

Medication penicillin + beta-lactamase inhibitor antibiotic
Aka: amoxicillin-clavulanate, Augmentin, Curam
Brands seen in Singapore: Augmentin, Curam, Moxiclav, Clamovid, Augmex
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Prescribed for ear, sinus, skin and dental infections
When to take
3 times a day for most people · at least 4 hours apart
Take with
Water · with a meal — NHS says this cuts nausea
Pros & cons
Pros
  • Eating as normal is fine while on it (NHS)
  • A meal at dosing cuts nausea (NHS)
  • 3 times a day suits most people (NHS)
Cons
  • Diarrhoea and nausea are common (NHS)
  • Past jaundice or liver trouble — label contraindication
  • Glandular fever — NHS says it may not be suitable
Sources
  1. HSA — Listing of Registered Therapeutic Products (official open dataset on data.gov.sg; full 5,511-row register pulled via the datastore_search API) · read 2026-08-27
    what it says
    “Forensicclassification = "Prescription Only" for all 26 amoxicillin + clavulanate products on the register (23 oral, 3 intravenous) — e.g. SIN09827P AUGMENTIN TABLET 625 mg, SIN10599P CURAM FILM-COATED TABLET, SIN10689P MOXICLAV 625, SIN12026P CLAMOVID 625, SIN11780P AUGMEX TABLET.”
  2. NHS Medicines A–Z — Co-amoxiclav, 'What co-amoxiclav is for' (common brands: Augmentin; single-page format, reviewed 14 April 2026) · read 2026-08-27
    what it says
    “Co-amoxiclav is a penicillin antibiotic used to treat some infections. It's only available with a prescription … ear and sinus infections … skin infections · dental infections.”
  3. NHS Medicines A–Z — Co-amoxiclav, 'How to take co-amoxiclav' (reviewed 14 April 2026) · read 2026-08-27
    what it says
    “Most people need to take it 3 times a day … space the doses evenly … at least 4 hours apart · take it with a meal (this helps reduce side effects such as feeling or being sick).”
  4. NHS Medicines A–Z — Co-amoxiclav, 'Side effects' and 'Who can and cannot take co-amoxiclav' (reviewed 14 April 2026) · read 2026-08-27
    what it says
    “Common side effects of co-amoxiclav include: diarrhoea · feeling sick (nausea) and being sick (vomiting) … it may not be suitable if … you have … glandular fever · you have kidney problems … You can eat as normal.”
  5. NHS Medicines A–Z — Co-amoxiclav, 'Taking co-amoxiclav with other medicines, food and drink' (reviewed 14 April 2026) · read 2026-08-27
    what it says
    “There are some medicines, remedies and supplements that may not mix well with co-amoxiclav. These include: gout medicines, such as allopurinol or probenecid · warfarin … · methotrexate.”
  6. FDA DailyMed — Amoxicillin and clavulanate potassium tablets, Dosage and Administration (A-S Medication Solutions), SPL effective 30 Apr 2024; via the openFDA drug label API · read 2026-08-27
    what it says
    “one 875 mg tablet … every 12 hours or one 500 mg tablet … every 8 hours … patients with a glomerular filtration rate (GFR) of less than 30 mL/min should NOT receive the 875 mg dose.”
  7. FDA DailyMed — Amoxicillin and clavulanate potassium tablets, Contraindications and Drug Interactions (A-S Medication Solutions), SPL effective 30 Apr 2024 · read 2026-08-27
    what it says
    “serious hypersensitivity reaction … cholestatic jaundice/hepatic dysfunction … probenecid is not recommended … oral anticoagulants may increase the prolongation of prothrombin time … allopurinol increases the risk of rash … may reduce efficacy of oral contraceptives.”
Report a correction View as JSON

Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.