{"ok":true,"entry":{"slug":"co-amoxiclav","kind":"medication","name":"co-amoxiclav","aliases":["amoxicillin-clavulanate","Augmentin","Curam"],"brands_sg":["Augmentin","Curam","Moxiclav","Clamovid","Augmex"],"class":"penicillin + beta-lactamase inhibitor","tags":["antibiotic"],"use_for":"prescribed for ear, sinus, skin and dental infections","use_after":"3 times a day for most people · at least 4 hours apart","use_duration":null,"take_with":"water · with a meal — nhs says this cuts nausea","pros":["eating as normal is fine while on it (nhs)","a meal at dosing cuts nausea (nhs)","3 times a day suits most people (nhs)"],"cons":["diarrhoea and nausea are common (nhs)","past jaundice or liver trouble — label contraindication","glandular fever — nhs says it may not be suitable"],"dose_note":"nhs: dose and length depend on why it is taken; most people take it 3 times a day. the us label's highest adult regimen is \"one 875 mg tablet every 12 hours or one 500 mg tablet every 8 hours\", and a gfr under 30 ml/min \"should NOT receive the 875 mg dose\". as directed on the label or by your pharmacist/doctor.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["serious hypersensitivity to penicillins or cephalosporins — us label contraindication","past cholestatic jaundice or hepatic dysfunction on this drug — us label contraindication","glandular fever — nhs says it may not be suitable","kidney problems — nhs says it may not be suitable"],"clashes":[{"src":["fda_coamox_safety","nhs_coamox_int"],"note":"us label: prothrombin time (inr) may be prolonged; nhs lists warfarin among medicines to declare","with":"warfarin / oral anticoagulants"},{"src":["fda_coamox_safety","nhs_coamox_int"],"note":"us label: co-administration increases the risk of rash; nhs lists gout medicines","with":"allopurinol"},{"src":["fda_coamox_safety","nhs_coamox_int"],"note":"us label does not recommend the combination; nhs lists gout medicines to declare","with":"probenecid"},{"src":["nhs_coamox_int"],"note":"nhs lists methotrexate among the medicines that may not mix well","with":"methotrexate"},{"src":["fda_coamox_safety"],"note":"us label: may reduce the efficacy of oral contraceptives","with":"oral contraceptives"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (official open dataset on data.gov.sg; full 5,511-row register pulled via the datastore_search API)","quote":"Forensicclassification = \"Prescription Only\" for all 26 amoxicillin + clavulanate products on the register (23 oral, 3 intravenous) — e.g. SIN09827P AUGMENTIN TABLET 625 mg, SIN10599P CURAM FILM-COATED TABLET, SIN10689P MOXICLAV 625, SIN12026P CLAMOVID 625, SIN11780P AUGMEX TABLET.","accessed":"2026-08-27"},{"id":"nhs_coamox_about","url":"https://www.nhs.uk/medicines/co-amoxiclav/","label":"NHS Medicines A–Z — Co-amoxiclav, 'What co-amoxiclav is for' (common brands: Augmentin; single-page format, reviewed 14 April 2026)","quote":"Co-amoxiclav is a penicillin antibiotic used to treat some infections. It's only available with a prescription … ear and sinus infections … skin infections · dental infections.","accessed":"2026-08-27"},{"id":"nhs_coamox_how","url":"https://www.nhs.uk/medicines/co-amoxiclav/","label":"NHS Medicines A–Z — Co-amoxiclav, 'How to take co-amoxiclav' (reviewed 14 April 2026)","quote":"Most people need to take it 3 times a day … space the doses evenly … at least 4 hours apart · take it with a meal (this helps reduce side effects such as feeling or being sick).","accessed":"2026-08-27"},{"id":"nhs_coamox_safety","url":"https://www.nhs.uk/medicines/co-amoxiclav/","label":"NHS Medicines A–Z — Co-amoxiclav, 'Side effects' and 'Who can and cannot take co-amoxiclav' (reviewed 14 April 2026)","quote":"Common side effects of co-amoxiclav include: diarrhoea · feeling sick (nausea) and being sick (vomiting) … it may not be suitable if … you have … glandular fever · you have kidney problems … You can eat as normal.","accessed":"2026-08-27"},{"id":"nhs_coamox_int","url":"https://www.nhs.uk/medicines/co-amoxiclav/","label":"NHS Medicines A–Z — Co-amoxiclav, 'Taking co-amoxiclav with other medicines, food and drink' (reviewed 14 April 2026)","quote":"There are some medicines, remedies and supplements that may not mix well with co-amoxiclav. These include: gout medicines, such as allopurinol or probenecid · warfarin … · methotrexate.","accessed":"2026-08-27"},{"id":"fda_coamox","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=00cf4429-e37c-4490-b22d-3cd796124296","label":"FDA DailyMed — Amoxicillin and clavulanate potassium tablets, Dosage and Administration (A-S Medication Solutions), SPL effective 30 Apr 2024; via the openFDA drug label API","quote":"one 875 mg tablet … every 12 hours or one 500 mg tablet … every 8 hours … patients with a glomerular filtration rate (GFR) of less than 30 mL/min should NOT receive the 875 mg dose.","accessed":"2026-08-27"},{"id":"fda_coamox_safety","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=00cf4429-e37c-4490-b22d-3cd796124296","label":"FDA DailyMed — Amoxicillin and clavulanate potassium tablets, Contraindications and Drug Interactions (A-S Medication Solutions), SPL effective 30 Apr 2024","quote":"serious hypersensitivity reaction … cholestatic jaundice/hepatic dysfunction … probenecid is not recommended … oral anticoagulants may increase the prolongation of prothrombin time … allopurinol increases the risk of rash … may reduce efficacy of oral contraceptives.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:16.693643+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}