CLA
Supplement
fatty acid
fitnessgeneral nutrition
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Body-fat change ODS calls small and of uncertain value
Studied for
Trials run 6–12 months at 2.4–6 g a day
Pros & cons
Pros
- Appears well tolerated across the trials
- Pooled result: −0.7 kg weight, −1.33 kg body fat
- Few safety concerns at 2.4–6 g/day up to 12 months
Cons
- ODS: effects small, clinical relevance uncertain
- GI upset is common; three hepatitis case reports
- T10,c12 isomer linked to insulin resistance in men
Sources
- NIH ODS — Dietary Supplements for Weight Loss (Health Professional), CLA efficacy · read 2026-08-27
what it says
“2.4–6 g/day CLA for 6–12 months reduces body weight by a mean of 0.7 kg and body fat by a mean of 1.33 kg compared to placebo … magnitude of these effects is small, and the clinical relevance is uncertain”
- NIH ODS — Dietary Supplements for Weight Loss (Health Professional), CLA safety · read 2026-08-27
what it says
“CLA appears to be well tolerated. Most reported adverse effects are minor, consisting mainly of gastrointestinal disturbances … CLA might also … decrease breastmilk fat levels … CLA has been linked to hepatitis in three case reports”
- NIH ODS — Dietary Supplements for Weight Loss (Health Professional), CLA lipid and glycaemic effects · read 2026-08-27
what it says
“certain CLA isomers might decrease HDL cholesterol and increase lipoprotein(a) levels … The CLA isomer t10,c12-CLA has also been reported to increase insulin resistance and glycemia in men with obesity and metabolic syndrome”
- NIH ODS — Dietary Supplements for Weight Loss (Health Professional), summary table row for CLA · read 2026-08-27
what it says
“Conjugated linoleic acid … Several clinical trials. Research findings: Minimal effect on body weight and body fat … Few safety concerns reported for 2.4–6 g/day for up to 12 months”
- HSA — Health Supplements Guidelines (Jan 2026), Tables 4 & 5 vitamin/mineral limits · read 2026-08-27
what it says
“HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.”
- HSA — Guidelines on prohibited and restricted ingredients in HS and TM (Oct 2025), Annex A/B · read 2026-08-27
what it says
“A list of specific prohibited and restricted ingredients is provided in Annex A … This list is not exhaustive. Dealers should continue to: Conduct thorough safety assessments of their products”
- iHerb Singapore — CLA category page, default order (1 - 35 of 35 results) · read 2026-08-27
what it says
“California Gold Nutrition, CLA, Conjugated Linoleic Acid, 1,000 mg … EVLution Nutrition, CLA1000®, Stimulant Free Weight Management … Sports Research, CLA 1250 … Force Factor, CLA, 1,000 mg … Nutricost, CLA, 240 Softgels”
Updated 2026-08-30. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.