{"ok":true,"entry":{"slug":"cla","kind":"supplement","name":"CLA","aliases":["conjugated linoleic acid"],"brands_sg":["California Gold Nutrition","EVLution Nutrition","Sports Research","Force Factor","Nutricost"],"class":"fatty acid","tags":["fitness","general"],"use_for":"body-fat change ODS calls small and of uncertain value","use_after":null,"use_duration":"trials run 6–12 months at 2.4–6 g a day","take_with":null,"pros":["appears well tolerated across the trials","pooled result: −0.7 kg weight, −1.33 kg body fat","few safety concerns at 2.4–6 g/day up to 12 months"],"cons":["ODS: effects small, clinical relevance uncertain","GI upset is common; three hepatitis case reports","t10,c12 isomer linked to insulin resistance in men"],"dose_note":"trials use 2.4–6 g a day for 6–12 months; ODS reports the pooled effect as roughly 0.7 kg of body weight and 1.33 kg of body fat versus placebo","dosage":{"ul":null,"unit":"g","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["metabolic syndrome or raised blood sugar — the t10,c12 isomer worsened insulin resistance in men","liver conditions — CLA has been linked to hepatitis in three case reports","breastfeeding — CLA might decrease breastmilk fat levels"],"clashes":[],"sources":[{"id":"ods_wl","url":"https://ods.od.nih.gov/factsheets/WeightLoss-HealthProfessional/","label":"NIH ODS — Dietary Supplements for Weight Loss (Health Professional), CLA efficacy","quote":"2.4–6 g/day CLA for 6–12 months reduces body weight by a mean of 0.7 kg and body fat by a mean of 1.33 kg compared to placebo … magnitude of these effects is small, and the clinical relevance is uncertain","accessed":"2026-08-27"},{"id":"ods_wl_safety","url":"https://ods.od.nih.gov/factsheets/WeightLoss-HealthProfessional/","label":"NIH ODS — Dietary Supplements for Weight Loss (Health Professional), CLA safety","quote":"CLA appears to be well tolerated. Most reported adverse effects are minor, consisting mainly of gastrointestinal disturbances … CLA might also … decrease breastmilk fat levels … CLA has been linked to hepatitis in three case reports","accessed":"2026-08-27"},{"id":"ods_wl_lipid","url":"https://ods.od.nih.gov/factsheets/WeightLoss-HealthProfessional/","label":"NIH ODS — Dietary Supplements for Weight Loss (Health Professional), CLA lipid and glycaemic effects","quote":"certain CLA isomers might decrease HDL cholesterol and increase lipoprotein(a) levels … The CLA isomer t10,c12-CLA has also been reported to increase insulin resistance and glycemia in men with obesity and metabolic syndrome","accessed":"2026-08-27"},{"id":"ods_wl_table","url":"https://ods.od.nih.gov/factsheets/WeightLoss-HealthProfessional/","label":"NIH ODS — Dietary Supplements for Weight Loss (Health Professional), summary table row for CLA","quote":"Conjugated linoleic acid … Several clinical trials. Research findings: Minimal effect on body weight and body fat … Few safety concerns reported for 2.4–6 g/day for up to 12 months","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (Jan 2026), Tables 4 & 5 vitamin/mineral limits","quote":"HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on prohibited and restricted ingredients in HS and TM (Oct 2025), Annex A/B","quote":"A list of specific prohibited and restricted ingredients is provided in Annex A … This list is not exhaustive. Dealers should continue to: Conduct thorough safety assessments of their products","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/cla","label":"iHerb Singapore — CLA category page, default order (1 - 35 of 35 results)","quote":"California Gold Nutrition, CLA, Conjugated Linoleic Acid, 1,000 mg … EVLution Nutrition, CLA1000®, Stimulant Free Weight Management … Sports Research, CLA 1250 … Force Factor, CLA, 1,000 mg … Nutricost, CLA, 240 Softgels","accessed":"2026-08-27"}],"brand_certs":[{"brand":"Sports Research","example":null,"programme":"NSF Certified for Sport","matching_products":0,"brand_total_certified":2},{"brand":"Force Factor","example":null,"programme":"NSF Certified for Sport","matching_products":0,"brand_total_certified":6}],"updated_at":"2026-08-30T17:59:38.376296+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}