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Citrus bioflavonoids

Supplement flavonoid blend heart & metabolic
Aka: bioflavonoid complex, hesperidin complex
Brands seen in Singapore: NOW Foods, Natural Factors, Vitacost, Solaray, Nature's Way
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Small shifts in blood lipids and inflammation markers
Pros & cons
Pros
  • Meta-analysis: LDL fell 0.22 mmol/l versus control
  • SAMe pooling: lower crp and adhesion molecules
  • Hesperidin is one half of MPFF, a grade a venoactive
Cons
  • Only 12 trials in 589 people — a small evidence base
  • Venous data are for MPFF or hmc, not plain complexes
  • No effect found on the other risk factors measured
Sources
  1. Effects of Citrus Flavanone Hesperidin Extracts or Purified Hesperidin Consumption on Risk Factors for Cardiovascular Disease: an Updated Meta-analysis of Randomized Controlled Trials (Huang et al., Current Developments in Nutrition 2024) · read 2026-08-27
    what it says
    “We included 12 trials with 589 participants. We found evident effects of hesperidin on low-density lipoprotein cholesterol (WMD: -0.22 mmol/L) … and C-reactive protein … whereas no effects were found for other CVDRFs.”
  2. The role of venoactive compounds in the treatment of chronic venous disease (Gloviczki, Kakkos, Urbanek, Chuback, Nicolaides; J Vasc Surg Venous Lymphat Disord 2025) — Table I dosages and Table IV evidence grades · read 2026-08-27
    what it says
    “Micronized purified flavonoid fraction (MPFF) and Ruscus extract combined with hesperidin methyl chalcone and ascorbic acid had the highest, mostly level A, quality of evidence.”
  3. HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (Oct 2025), Annex A (105 rows) and Annex B (4 rows) — read from the cached PDF text on disk · read 2026-08-27
    what it says
    “The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.”
  4. HSA — Health Supplements Guidelines, GL-CHPB-3-001 Rev. No. 020 (January 2026), section 4.8 with Tables 4 and 5 (vitamins and minerals limits) — read from the cached PDF text on disk · read 2026-08-27
    what it says
    “HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.”
  5. HSA — Health Supplements Guidelines, GL-CHPB-3-001 Rev. No. 020 (January 2026), section 6.6 and Table 6: diseases/conditions not allowed for health supplements — read from the cached PDF text on disk · read 2026-08-27
    what it says
    “HS must not be labelled, advertised or promoted for any specific medicinal purpose … Blood and circulatory system: … cholesterol disorders, reduces cholesterol … Immune system: Leprosy, AIDS, allergies, immunisation”
  6. iHerb Singapore — Bioflavonoids category page, default order, read 27 Aug 2026 via WebFetch · read 2026-08-27
    what it says
    “Bioflavonoids … NOW Foods … Natural Factors … Vitacost … Solaray … Solaray … Vitacost … Nature's Way”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.