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Chlorella

Supplement freshwater algae general nutritiongut
Aka: Chlorella vulgaris, broken cell wall chlorella
Brands seen in Singapore: NOW Foods, Earth Circle Organics, Micro Ingredients, Source Naturals, Dr. Mercola
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Limited human evidence — small shifts in body/lipid markers
Pros & cons
Pros
  • 24 trials pooled: small drops in bmi and LDL
  • May modulate gut microbiota — mostly animal data
Cons
  • Grade certainty was very low for most outcomes
  • A 2025 meta-analysis: neutral effect on bp and lipids
  • Few human gut trials — most of the data are preclinical
Sources
  1. Mardani H et al. — Beneficial effects of Chlorella species supplementation in the general population: a GRADE-assessed systematic review and dose-response meta-analysis, Nutr Diabetes 2026 · read 2026-08-27
    what it says
    “A total of 24 studies were included … BMI (WMD = −0.30 kg/m2) … low-density lipoprotein cholesterol (WMD = −6.20 mg/dl) … the certainty of evidence for most other outcomes was very low”
  2. Mardani H et al., Nutr Diabetes 2026 — GRADE rating and authors' caveat · read 2026-08-27
    what it says
    “While the evidence for BMI was rated as low, the certainty of evidence for most other outcomes was very low according to the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) … these results should be interpreted cautiously”
  3. Pinto-Leite M et al. — The Role of Chlorella and Spirulina as Adjuvants of Cardiovascular Risk Factor Control: A Systematic Review and Meta-Analysis of Randomised Controlled Trials, Nutrients 2025 · read 2026-08-27
    what it says
    “We found 12 studies in Chlorella … Our analysis showed that Chlorella supplementation had a neutral effect on BP and lipemia … Further randomised trials are needed to better assess the potential of these supplements”
  4. Felip O et al. — Effects of the Edible Microalga Chlorella on Gut Microbiota and on Brain Health: Current Evidence and Emerging Links, Nutrients 2026 (PROSPERO CRD42024527705) · read 2026-08-27
    what it says
    “Most of the studies included were conducted in animal models, with only a limited number of human trials. Nineteen studies (90%), predominantly preclinical, reported positive associations between Chlorella consumption, gut microbiota modulation, and physiological or neurobehavioral markers”
  5. HSA Singapore — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (October 2025), Annex A (118 rows) and Annex B (4 rows) — chlorella not listed in either · read 2026-08-27
    what it says
    “The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.”
  6. HSA Singapore — Health Supplements Guidelines GL-CHPB-3-001 Rev. No. 020 (January 2026), clause 4.8 with Tables 4–5 (vitamins and minerals only — no chlorella row) · read 2026-08-27
    what it says
    “4.8 HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.”
  7. iHerb Singapore — Chlorella category page, default listing order · read 2026-08-27
    what it says
    “1 - 45 of 45 results … NOW Foods, Chlorella, 120 Tablets … Earth Circle Organics, 100% Organic Chlorella … Micro Ingredients, Organic Spirulina Chlorella … Source Naturals, Yaeyama Chlorella® … Dr. Mercola, Fermented Chlorella with Chlorophyll”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.