{"ok":true,"entry":{"slug":"chlorella","kind":"supplement","name":"chlorella","aliases":["Chlorella vulgaris","broken cell wall chlorella"],"brands_sg":["NOW Foods","Earth Circle Organics","Micro Ingredients","Source Naturals","Dr. Mercola"],"class":"freshwater algae","tags":["general","gut"],"use_for":"limited human evidence — small shifts in body/lipid markers","use_after":null,"use_duration":null,"take_with":null,"pros":["24 trials pooled: small drops in bmi and ldl","may modulate gut microbiota — mostly animal data"],"cons":["grade certainty was very low for most outcomes","a 2025 meta-analysis: neutral effect on bp and lipids","few human gut trials — most of the data are preclinical"],"dose_note":"a 2026 grade-assessed systematic review and dose-response meta-analysis of 24 studies in the general population reported reductions in body fat percentage (−0.73%), bmi (−0.30 kg/m2), weight (−1.28 kg), ldl cholesterol (−6.20 mg/dl) and total cholesterol (−8.03 mg/dl), with the evidence for bmi rated low and most other outcomes very low, and the authors say the results should be interpreted cautiously; a separate 2025 meta-analysis of 12 chlorella trials found a neutral effect on blood pressure and lipids; on the gut, a 2026 prisma systematic review of 21 studies found 90% reported positive associations with gut-microbiota modulation but says most were animal models with only a limited number of human trials; no rda, ul, fda daily value or hsa singapore daily limit exists for chlorella, and the dose ranges used in those trials were not stated in the abstracts read, so no dose figure is given here","dosage":{"ul":null,"unit":null,"fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["not listed in hsa's prohibited or restricted annexes — that is not a safety finding","no ul and no hsa daily limit exist, so there is no ceiling to check a label against","human evidence is limited and mostly short trials in small groups"],"clashes":[],"sources":[{"id":"mardani2026","url":"https://europepmc.org/article/MED/42420253","label":"Mardani H et al. — Beneficial effects of Chlorella species supplementation in the general population: a GRADE-assessed systematic review and dose-response meta-analysis, Nutr Diabetes 2026","quote":"A total of 24 studies were included … BMI (WMD = −0.30 kg/m2) … low-density lipoprotein cholesterol (WMD = −6.20 mg/dl) … the certainty of evidence for most other outcomes was very low","accessed":"2026-08-27"},{"id":"mardani2026_grade","url":"https://europepmc.org/article/MED/42420253","label":"Mardani H et al., Nutr Diabetes 2026 — GRADE rating and authors' caveat","quote":"While the evidence for BMI was rated as low, the certainty of evidence for most other outcomes was very low according to the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) … these results should be interpreted cautiously","accessed":"2026-08-27"},{"id":"pintoleite2025","url":"https://europepmc.org/article/MED/40289965","label":"Pinto-Leite M et al. — The Role of Chlorella and Spirulina as Adjuvants of Cardiovascular Risk Factor Control: A Systematic Review and Meta-Analysis of Randomised Controlled Trials, Nutrients 2025","quote":"We found 12 studies in Chlorella … Our analysis showed that Chlorella supplementation had a neutral effect on BP and lipemia … Further randomised trials are needed to better assess the potential of these supplements","accessed":"2026-08-27"},{"id":"felip2026","url":"https://europepmc.org/article/MED/42356400","label":"Felip O et al. — Effects of the Edible Microalga Chlorella on Gut Microbiota and on Brain Health: Current Evidence and Emerging Links, Nutrients 2026 (PROSPERO CRD42024527705)","quote":"Most of the studies included were conducted in animal models, with only a limited number of human trials. Nineteen studies (90%), predominantly preclinical, reported positive associations between Chlorella consumption, gut microbiota modulation, and physiological or neurobehavioral markers","accessed":"2026-08-27"},{"id":"hsa_prohibited","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA Singapore — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (October 2025), Annex A (118 rows) and Annex B (4 rows) — chlorella not listed in either","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"hsa_hs_guidelines","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA Singapore — Health Supplements Guidelines GL-CHPB-3-001 Rev. No. 020 (January 2026), clause 4.8 with Tables 4–5 (vitamins and minerals only — no chlorella row)","quote":"4.8 HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/chlorella","label":"iHerb Singapore — Chlorella category page, default listing order","quote":"1 - 45 of 45 results … NOW Foods, Chlorella, 120 Tablets … Earth Circle Organics, 100% Organic Chlorella … Micro Ingredients, Organic Spirulina Chlorella … Source Naturals, Yaeyama Chlorella® … Dr. Mercola, Fermented Chlorella with Chlorophyll","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:14.713299+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}