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Carvedilol

Medication beta blocker heart & blood pressure
Aka: Dilatrend
Brands seen in Singapore: Dilatrend, Vacodil, Carvedilol Sandoz
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
High blood pressure, angina and chronic heart failure
When to take
SG label: long-term use, reduced gradually not stopped
Take with
HealthHub: with or after food · swallowed with fluid
Pros & cons
Pros
  • SG label: once a day is enough for hypertension
  • 6.25, 12.5 and 25 mg strengths registered in SG
  • SG label: no dose change for renal impairment
Cons
  • Dizziness, cold hands and feet and tiredness are common
  • SG label: contraindicated with asthma or bronchospasm
  • HealthHub: it can mask low-blood-sugar warning signs
Sources
  1. HSA — Listing of Registered Therapeutic Products (data.gov.sg dataset d_767279312753558cbf19d48344577084), Forensicclassification column; all 5,511 rows cached at /tmp/hsa_all.json and filtered locally, 27 Aug 2026 · read 2026-08-27
    what it says
    “DILATREND TABLET 25 mg SIN07421P | CARVEDILOL | Prescription Only | C07AG02; DILATREND TABLET 12.5 mg SIN10335P; Vacodil 6.25/12.5/25 SIN14644P/SIN14643P/SIN14642P; Carvedilol Sandoz 6.25mg SIN13155P; Carvedilol Sandoz 25mg SIN13156P — all 7 carvedilol rows 'Prescription Only'”
  2. MOH National Drug Formulary (Singapore) — DILATREND TABLET 25 MG [SIN07421P], product information and forensic classification · read 2026-08-27
    what it says
    “CARVEDILOL - 25 MG … Registration Number SIN07421P … Licence Holder DKSH SINGAPORE PTE. LTD. … Forensic Classification PRESCRIPTION ONLY MEDICINES … ATC code C07AG02 … Prescription-only Medicines with Exemptions for Supply without Prescription: NA”
  3. MOH National Drug Formulary (Singapore) — DILATREND [SIN07421P], 2.1 Therapeutic Indications · read 2026-08-27
    what it says
    “Dilatrend is indicated for the management of essential hypertension … Carvedilol has demonstrated anti-ischemic and anti-anginal properties in patients with coronary heart disease … Dilatrend is indicated for the treatment of symptomatic chronic heart failure (CHF) to reduce mortality and cardiovascular hospitalisations”
  4. MOH National Drug Formulary (Singapore) — DILATREND [SIN07421P], 2.2 Dosage: hypertension and angina maxima · read 2026-08-27
    what it says
    “increased at intervals of at least two weeks to the recommended maximum daily dose of 50 mg given once or twice daily … up to the recommended maximum daily dose of 100 mg given in divided doses (twice daily)”
  5. MOH National Drug Formulary (Singapore) — DILATREND [SIN07421P], 2.2 Dosage: chronic heart failure maximum · read 2026-08-27
    what it says
    “The maximum recommended dose is 25 mg twice daily for all patients with severe CHF and for patients with mild to moderate CHF weighing less than 85 kg (187 lbs)”
  6. MOH National Drug Formulary (Singapore) — DILATREND [SIN07421P], 2.2 Dosage: chronic heart failure above 85 kg · read 2026-08-27
    what it says
    “In patients with mild or moderate CHF weighing more than 85 kg, the maximum recommended dose is 50 mg twice daily”
  7. MOH National Drug Formulary (Singapore) — DILATREND [SIN07421P], 2.2.1 Special Dosage Instructions: renal impairment · read 2026-08-27
    what it says
    “Available pharmacokinetic data and published clinical studies in patients with varying degrees of renal impairment (including renal failure) suggest no changes in Dilatrend dosing recommendations are warranted in patients with moderate to severe renal insufficiency”
  8. MOH National Drug Formulary (Singapore) — DILATREND [SIN07421P], 2.2 Method of administration and duration of treatment · read 2026-08-27
    what it says
    “The tablets are to be swallowed with sufficient fluid … Treatment with carvedilol is a long-term therapy. As with all β-blockers, treatment should not be stopped abruptly but rather gradually reduced at weekly intervals”
  9. MOH National Drug Formulary (Singapore) — DILATREND [SIN07421P], 2.3 Contraindications · read 2026-08-27
    what it says
    “Dilatrend must not be used in patients with: … unstable/decompensated heart failure … clinically manifest liver dysfunction … 2nd and 3rd degree atrioventricular (AV) block … Severe bradycardia (< 50 bpm) … Cardiogenic shock … History of bronchospasm or asthma”
  10. HealthHub (MOH Singapore) — Carvedilol, Medication Information Leaflet · read 2026-08-27
    what it says
    “Carvedilol belongs to a group of medications known as beta-blockers … You may take this medication with or after food … Stopping your medication suddenly may worsen your condition”
  11. HealthHub (MOH Singapore) — Carvedilol, precautions · read 2026-08-27
    what it says
    “You have asthma or other breathing problems – this medication may worsen or cause an asthma attack. You have pre-diabetes or diabetes - this medication may hide symptoms of low blood sugar such as fast heartbeat or tremors”
  12. HealthHub (MOH Singapore) — Carvedilol, common side effects · read 2026-08-27
    what it says
    “Dizziness and lightheadedness … Coldness, numbness or tingling sensation of your fingers or toes … Feeling weak and tired, and that your heart beats slower … Shortness of breath … Problems with sexual intercourse”
  13. NHS medicines A–Z — Carvedilol, taking it with other medicines and herbal supplements (reviewed 5 July 2024) · read 2026-08-27
    what it says
    “other medicines for high blood pressure … medicines for an irregular heartbeat such as digoxin, amiodarone or flecainide … medicines for diabetes, particularly insulin … non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, diclofenac or naproxen”
  14. NHS medicines A–Z — Carvedilol, further cautions with other medicines · read 2026-08-27
    what it says
    “medicines that treat nose or sinus congestion, or other cold remedies (including those you can buy in the pharmacy) … medicines for allergies, such as ephedrine, noradrenaline or adrenaline … ciclosporin, used for immune conditions”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.