{"ok":true,"entry":{"slug":"carvedilol","kind":"medication","name":"carvedilol","aliases":["Dilatrend"],"brands_sg":["Dilatrend","Vacodil","Carvedilol Sandoz"],"class":"beta blocker","tags":["heart-bp"],"use_for":"high blood pressure, angina and chronic heart failure","use_after":"sg label: long-term use, reduced gradually not stopped","use_duration":null,"take_with":"healthhub: with or after food · swallowed with fluid","pros":["sg label: once a day is enough for hypertension","6.25, 12.5 and 25 mg strengths registered in sg","sg label: no dose change for renal impairment"],"cons":["dizziness, cold hands and feet and tiredness are common","sg label: contraindicated with asthma or bronchospasm","healthhub: it can mask low-blood-sugar warning signs"],"dose_note":"the sg dilatrend label (sin07421p) sets a different maximum for each use: in hypertension the dose may be \"increased at intervals of at least two weeks to the recommended maximum daily dose of 50 mg given once or twice daily\"; in angina \"up to the recommended maximum daily dose of 100 mg given in divided doses (twice daily)\"; and in chronic heart failure \"The maximum recommended dose is 25 mg twice daily for all patients with severe CHF and for patients with mild to moderate CHF weighing less than 85 kg\", while \"In patients with mild or moderate CHF weighing more than 85 kg, the maximum recommended dose is 50 mg twice daily\" — as directed on the label or by your doctor","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["asthma or other breathing problems — healthhub: it may worsen or cause an asthma attack, and a history of bronchospasm or asthma is an sg label contraindication","diabetes or pre-diabetes — healthhub: it may hide symptoms of low blood sugar such as a fast heartbeat or tremors","clinically manifest liver dysfunction, severe bradycardia under 50 bpm, 2nd or 3rd degree av block without a pacemaker, sick sinus syndrome, severe hypotension or cardiogenic shock — sg label contraindications","pregnant, planning pregnancy or breastfeeding — healthhub asks that this be declared before starting"],"clashes":[{"src":["nhs_carvedilol_int"],"note":"nhs: taken together with carvedilol they can sometimes lower blood pressure too much","with":"other blood pressure medicines"},{"src":["nhs_carvedilol_int"],"note":"nhs lists medicines for an irregular heartbeat among those that affect how carvedilol works","with":"heart-rhythm medicines such as digoxin, amiodarone or flecainide"},{"src":["nhs_carvedilol_int","healthhub_carvedilol_prec"],"note":"nhs: carvedilol may lower blood sugar too much and make the warning signs harder to recognise","with":"diabetes medicines, particularly insulin"},{"src":["nhs_carvedilol_int"],"note":"nhs: these medicines may increase blood pressure","with":"nsaids such as ibuprofen, diclofenac or naproxen"},{"src":["nhs_carvedilol_int2"],"note":"nhs lists nose or sinus congestion remedies and allergy medicines among those to declare","with":"decongestants, cold remedies and allergy medicines (ephedrine, adrenaline)"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/api/action/datastore_search?resource_id=d_767279312753558cbf19d48344577084&limit=6000","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg dataset d_767279312753558cbf19d48344577084), Forensicclassification column; all 5,511 rows cached at /tmp/hsa_all.json and filtered locally, 27 Aug 2026","quote":"DILATREND TABLET 25 mg SIN07421P | CARVEDILOL | Prescription Only | C07AG02; DILATREND TABLET 12.5 mg SIN10335P; Vacodil 6.25/12.5/25 SIN14644P/SIN14643P/SIN14642P; Carvedilol Sandoz 6.25mg SIN13155P; Carvedilol Sandoz 25mg SIN13156P — all 7 carvedilol rows 'Prescription Only'","accessed":"2026-08-27"},{"id":"ndf_dilatrend","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin07421p/","label":"MOH National Drug Formulary (Singapore) — DILATREND TABLET 25 MG [SIN07421P], product information and forensic classification","quote":"CARVEDILOL - 25 MG … Registration Number SIN07421P … Licence Holder DKSH SINGAPORE PTE. LTD. … Forensic Classification PRESCRIPTION ONLY MEDICINES … ATC code C07AG02 … Prescription-only Medicines with Exemptions for Supply without Prescription: NA","accessed":"2026-08-27"},{"id":"ndf_dilatrend_ind","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin07421p/","label":"MOH National Drug Formulary (Singapore) — DILATREND [SIN07421P], 2.1 Therapeutic Indications","quote":"Dilatrend is indicated for the management of essential hypertension … Carvedilol has demonstrated anti-ischemic and anti-anginal properties in patients with coronary heart disease … Dilatrend is indicated for the treatment of symptomatic chronic heart failure (CHF) to reduce mortality and cardiovascular hospitalisations","accessed":"2026-08-27"},{"id":"ndf_dilatrend_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin07421p/","label":"MOH National Drug Formulary (Singapore) — DILATREND [SIN07421P], 2.2 Dosage: hypertension and angina maxima","quote":"increased at intervals of at least two weeks to the recommended maximum daily dose of 50 mg given once or twice daily … up to the recommended maximum daily dose of 100 mg given in divided doses (twice daily)","accessed":"2026-08-27"},{"id":"ndf_dilatrend_chf","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin07421p/","label":"MOH National Drug Formulary (Singapore) — DILATREND [SIN07421P], 2.2 Dosage: chronic heart failure maximum","quote":"The maximum recommended dose is 25 mg twice daily for all patients with severe CHF and for patients with mild to moderate CHF weighing less than 85 kg (187 lbs)","accessed":"2026-08-27"},{"id":"ndf_dilatrend_chf2","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin07421p/","label":"MOH National Drug Formulary (Singapore) — DILATREND [SIN07421P], 2.2 Dosage: chronic heart failure above 85 kg","quote":"In patients with mild or moderate CHF weighing more than 85 kg, the maximum recommended dose is 50 mg twice daily","accessed":"2026-08-27"},{"id":"ndf_dilatrend_renal","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin07421p/","label":"MOH National Drug Formulary (Singapore) — DILATREND [SIN07421P], 2.2.1 Special Dosage Instructions: renal impairment","quote":"Available pharmacokinetic data and published clinical studies in patients with varying degrees of renal impairment (including renal failure) suggest no changes in Dilatrend dosing recommendations are warranted in patients with moderate to severe renal insufficiency","accessed":"2026-08-27"},{"id":"ndf_dilatrend_stop","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin07421p/","label":"MOH National Drug Formulary (Singapore) — DILATREND [SIN07421P], 2.2 Method of administration and duration of treatment","quote":"The tablets are to be swallowed with sufficient fluid … Treatment with carvedilol is a long-term therapy. As with all β-blockers, treatment should not be stopped abruptly but rather gradually reduced at weekly intervals","accessed":"2026-08-27"},{"id":"ndf_dilatrend_ci","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin07421p/","label":"MOH National Drug Formulary (Singapore) — DILATREND [SIN07421P], 2.3 Contraindications","quote":"Dilatrend must not be used in patients with: … unstable/decompensated heart failure … clinically manifest liver dysfunction … 2nd and 3rd degree atrioventricular (AV) block … Severe bradycardia (< 50 bpm) … Cardiogenic shock … History of bronchospasm or asthma","accessed":"2026-08-27"},{"id":"healthhub_carvedilol","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/carvedilol","label":"HealthHub (MOH Singapore) — Carvedilol, Medication Information Leaflet","quote":"Carvedilol belongs to a group of medications known as beta-blockers … You may take this medication with or after food … Stopping your medication suddenly may worsen your condition","accessed":"2026-08-27"},{"id":"healthhub_carvedilol_prec","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/carvedilol","label":"HealthHub (MOH Singapore) — Carvedilol, precautions","quote":"You have asthma or other breathing problems – this medication may worsen or cause an asthma attack. You have pre-diabetes or diabetes - this medication may hide symptoms of low blood sugar such as fast heartbeat or tremors","accessed":"2026-08-27"},{"id":"healthhub_carvedilol_se","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/carvedilol","label":"HealthHub (MOH Singapore) — Carvedilol, common side effects","quote":"Dizziness and lightheadedness … Coldness, numbness or tingling sensation of your fingers or toes … Feeling weak and tired, and that your heart beats slower … Shortness of breath … Problems with sexual intercourse","accessed":"2026-08-27"},{"id":"nhs_carvedilol_int","url":"https://www.nhs.uk/medicines/carvedilol/taking-carvedilol-with-other-medicines-and-herbal-supplements/","label":"NHS medicines A–Z — Carvedilol, taking it with other medicines and herbal supplements (reviewed 5 July 2024)","quote":"other medicines for high blood pressure … medicines for an irregular heartbeat such as digoxin, amiodarone or flecainide … medicines for diabetes, particularly insulin … non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, diclofenac or naproxen","accessed":"2026-08-27"},{"id":"nhs_carvedilol_int2","url":"https://www.nhs.uk/medicines/carvedilol/taking-carvedilol-with-other-medicines-and-herbal-supplements/","label":"NHS medicines A–Z — Carvedilol, further cautions with other medicines","quote":"medicines that treat nose or sinus congestion, or other cold remedies (including those you can buy in the pharmacy) … medicines for allergies, such as ephedrine, noradrenaline or adrenaline … ciclosporin, used for immune conditions","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:14.713299+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}