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Calcium D-glucarate

Supplement specialty compound general nutritionwomen's health
Aka: CDG, D-glucarate
Brands seen in Singapore: Nutricost, NOW Foods, Life Extension, Source Naturals, SMNutrition
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Estrogen metabolism — limited human evidence
Pros & cons
Pros
  • Inhibits beta-glucuronidase in oral supplementation
  • Described as a naturally occurring non-toxic compound
Cons
  • Human uses are still described as 'potential'
  • The supporting work is mouse and cell-model data
  • Not on HSA's lists — that is not a safety clearance
Sources
  1. Calcium-D-glucarate (monograph, Alternative Medicine Review 2002;7:336-9) · read 2026-08-27
    what it says
    “Oral supplementation of calcium-D-glucarate has been shown to inhibit beta-glucuronidase … Other potential clinical applications of oral calcium-D-glucarate include regulation of estrogen metabolism and as a lipid-lowering agent.”
  2. Induction of apoptosis by calcium D-glucarate in DMBA-exposed mouse skin (J Environ Pathol Toxicol Oncol 2007) · read 2026-08-27
    what it says
    “Calcium glucarate (Cag), a naturally occurring nontoxic compound, suppresses the DMBA-induced tumor development in mouse skin.”
  3. HSA — Health Supplements Guidelines (Jan 2026), Tables 4 & 5 vitamin/mineral limits · read 2026-08-27
    what it says
    “HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.”
  4. HSA — Guidelines on prohibited and restricted ingredients in HS and TM (Oct 2025), Annex A/B · read 2026-08-27
    what it says
    “A list of specific prohibited and restricted ingredients is provided in Annex A … This list is not exhaustive. Dealers should continue to: Conduct thorough safety assessments of their products”
  5. iHerb Singapore — Calcium D-Glucarate category page (Supplements > Minerals > Calcium), default order · read 2026-08-27
    what it says
    “Nutricost, Calcium D-Glucarate, 500 mg, 120 Capsules … NOW Foods, Calcium D-Glucarate, 500 mg, 90 Veg Capsules … Life Extension, Calcium D-Glucarate, 200 mg, 60 Vegetarian Capsules”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.