{"ok":true,"entry":{"slug":"calcium-d-glucarate","kind":"supplement","name":"calcium D-glucarate","aliases":["CDG","D-glucarate"],"brands_sg":["Nutricost","NOW Foods","Life Extension","Source Naturals","SMNutrition"],"class":"specialty compound","tags":["general","womens-health"],"use_for":"estrogen metabolism — limited human evidence","use_after":null,"use_duration":null,"take_with":null,"pros":["inhibits beta-glucuronidase in oral supplementation","described as a naturally occurring non-toxic compound"],"cons":["human uses are still described as 'potential'","the supporting work is mouse and cell-model data","not on HSA's lists — that is not a safety clearance"],"dose_note":"the sources read give no established human dose; the 2002 monograph describes mechanism and 'potential clinical applications', and the supporting studies are animal and in-vitro","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["on hormone therapy — altering estrogen metabolism is the proposed action","pregnancy or breastfeeding — no human safety data was located"],"clashes":[],"sources":[{"id":"amr2002","url":"https://europepmc.org/article/MED/12197785","label":"Calcium-D-glucarate (monograph, Alternative Medicine Review 2002;7:336-9)","quote":"Oral supplementation of calcium-D-glucarate has been shown to inhibit beta-glucuronidase … Other potential clinical applications of oral calcium-D-glucarate include regulation of estrogen metabolism and as a lipid-lowering agent.","accessed":"2026-08-27"},{"id":"cag2007","url":"https://europepmc.org/article/MED/17725531","label":"Induction of apoptosis by calcium D-glucarate in DMBA-exposed mouse skin (J Environ Pathol Toxicol Oncol 2007)","quote":"Calcium glucarate (Cag), a naturally occurring nontoxic compound, suppresses the DMBA-induced tumor development in mouse skin.","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (Jan 2026), Tables 4 & 5 vitamin/mineral limits","quote":"HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on prohibited and restricted ingredients in HS and TM (Oct 2025), Annex A/B","quote":"A list of specific prohibited and restricted ingredients is provided in Annex A … This list is not exhaustive. Dealers should continue to: Conduct thorough safety assessments of their products","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/calcium-d-glucarate","label":"iHerb Singapore — Calcium D-Glucarate category page (Supplements > Minerals > Calcium), default order","quote":"Nutricost, Calcium D-Glucarate, 500 mg, 120 Capsules … NOW Foods, Calcium D-Glucarate, 500 mg, 90 Veg Capsules … Life Extension, Calcium D-Glucarate, 200 mg, 60 Vegetarian Capsules","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:14.713299+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}