Bupropion
Medication
atypical antidepressant
mental health
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Prescribed for depression; also used to help quit smoking
When to take
HealthHub: two daily doses sit at least 8 hours apart
Take with
Water · HealthHub: with or without food, swallowed whole
Pros & cons
Pros
- HealthHub: may be taken with or without food
- HealthHub: also used in a 7–12 week quit-smoking course
- FDA label: the sr form is dosed once or twice a day
Cons
- HealthHub: poor sleep, dry mouth, nausea, headache
- HealthHub: seizures are a rare but listed risk
- HealthHub: may raise blood pressure
Sources
- HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached locally at /tmp/hsa_all.json and filtered offline) · read 2026-08-27
what it says
“Both bupropion-containing rows carry Forensicclassification 'Prescription Only' — SIN10983P WELLBUTRIN SR TABLETS 150 mg (bupropion HCl, ATC N06AX12) and SIN16411P CONTRAVE PROLONGED RELEASE TABLET 8MG/90MG (with naltrexone). No ZYBAN row exists.”
- HealthHub (National Medication Information workgroup, SG) — Bupropion: what is this medication for · read 2026-08-27
what it says
“Bupropion belongs to a class of medications known as Norepinephrine and Dopamine Reuptake Inhibitors (NDRI). It is used to treat symptoms of depression … Bupropion may also be used for other conditions, such as helping smokers to quit smoking.”
- HealthHub — Bupropion: how should I take or use this medication · read 2026-08-27
what it says
“Bupropion may be taken with or without food. Swallow the tablet whole. Do NOT break, split or crush the tablet … the second dose at least 8 hours apart … 7-12 weeks to help you quit smoking”
- HealthHub — Bupropion: what precautions should I take · read 2026-08-27
what it says
“You have or have ever had: … Heart, kidney or liver disease; Medical conditions such as seizures (fits), eating disorders … bipolar disorder, abnormally high or excited mood (mania) or schizophrenia … Bupropion may increase your blood pressure.”
- HealthHub — Bupropion: common side effects · read 2026-08-27
what it says
“Nausea, vomiting or loss of appetite … Difficulty sleeping … Dry mouth … Constipation … Mild nervousness … Headache … Weight loss, sweating … Problems with eyesight”
- HealthHub — Bupropion: rare but serious side effects · read 2026-08-27
what it says
“Rarely this medication may cause: … signs and symptoms of liver problem … Strong feelings of agitation or anxiety … signs and symptoms of mania … Seizures (fits) … Fast, pounding or irregular heartbeat”
- HealthHub — Bupropion: what food or medication should I avoid · read 2026-08-27
what it says
“Avoid drinking alcohol while taking Bupropion as it can worsen the symptoms of your depression and cause excessive sleepiness.”
- US FDA label for WELLBUTRIN SR (bupropion hydrochloride), section 2 Dosage and Administration, via openFDA drug/label.json (effective 2025-11-05) · read 2026-08-27
what it says
“Maximum dose: 400 mg/day, given as 200 mg twice daily, for patients not responding to 300 mg/day … To avoid high peak concentrations of bupropion and/or its metabolites, do not exceed 200 mg in any single dose.”
- US FDA label for WELLBUTRIN SR, sections 2.4–2.5 Switching to or from an MAOI, via openFDA drug/label.json (effective 2025-11-05) · read 2026-08-27
what it says
“At least 14 days should elapse between discontinuation of an MAOI … and initiation of therapy with WELLBUTRIN SR … Do not start WELLBUTRIN SR in a patient … being treated with a reversible MAOI such as linezolid”
Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.