{"ok":true,"entry":{"slug":"bupropion","kind":"medication","name":"bupropion","aliases":["Wellbutrin","amfebutamone"],"brands_sg":["Wellbutrin SR"],"class":"atypical antidepressant","tags":["mental-health"],"use_for":"prescribed for depression; also used to help quit smoking","use_after":"healthhub: two daily doses sit at least 8 hours apart","use_duration":null,"take_with":"water · healthhub: with or without food, swallowed whole","pros":["healthhub: may be taken with or without food","healthhub: also used in a 7–12 week quit-smoking course","fda label: the sr form is dosed once or twice a day"],"cons":["healthhub: poor sleep, dry mouth, nausea, headache","healthhub: seizures are a rare but listed risk","healthhub: may raise blood pressure"],"dose_note":"the us fda label for wellbutrin sr — the only single-ingredient bupropion product on the sg register — gives a usual adult target of 300 mg/day and states 'Maximum dose: 400 mg/day, given as 200 mg twice daily, for patients not responding to 300 mg/day', adding 'do not exceed 200 mg in any single dose'. with moderate to severe hepatic impairment the same label caps it at 100 mg daily or 150 mg every other day. the sg-registered strength is 150 mg. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["any history of seizures or an eating disorder (healthhub)","bipolar disorder, mania or schizophrenia (healthhub)","heart, kidney or liver disease (healthhub)","another low-mood medicine in the past 2 weeks (healthhub, fda)"],"clashes":[{"src":["hh_bupro_interactions"],"food":true,"note":"healthhub: it can worsen the symptoms of your depression and cause excessive sleepiness","with":"alcohol"},{"src":["fda_wellbutrin_maoi"],"note":"fda label: at least 14 days should elapse between stopping an maoi and starting wellbutrin sr, and the same in reverse","with":"maoi antidepressants"},{"src":["fda_wellbutrin_maoi"],"note":"fda label: do not start wellbutrin sr in a patient being treated with a reversible maoi such as linezolid","with":"linezolid and other reversible maois"},{"src":["hh_bupro_precautions"],"note":"healthhub asks about supplements such as st john's wort, traditional medications and herbal remedies before starting","with":"st john's wort and other herbal remedies"},{"src":["hsa_register"],"note":"the sg register carries CONTRAVE, a bupropion-plus-naltrexone tablet — the same active taken twice if both are used","with":"naltrexone (as the fixed-dose combination contrave)"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached locally at /tmp/hsa_all.json and filtered offline)","quote":"Both bupropion-containing rows carry Forensicclassification 'Prescription Only' — SIN10983P WELLBUTRIN SR TABLETS 150 mg (bupropion HCl, ATC N06AX12) and SIN16411P CONTRAVE PROLONGED RELEASE TABLET 8MG/90MG (with naltrexone). No ZYBAN row exists.","accessed":"2026-08-27"},{"id":"hh_bupro_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/bupropion","label":"HealthHub (National Medication Information workgroup, SG) — Bupropion: what is this medication for","quote":"Bupropion belongs to a class of medications known as Norepinephrine and Dopamine Reuptake Inhibitors (NDRI). It is used to treat symptoms of depression … Bupropion may also be used for other conditions, such as helping smokers to quit smoking.","accessed":"2026-08-27"},{"id":"hh_bupro_howto","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/bupropion","label":"HealthHub — Bupropion: how should I take or use this medication","quote":"Bupropion may be taken with or without food. Swallow the tablet whole. Do NOT break, split or crush the tablet … the second dose at least 8 hours apart … 7-12 weeks to help you quit smoking","accessed":"2026-08-27"},{"id":"hh_bupro_precautions","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/bupropion","label":"HealthHub — Bupropion: what precautions should I take","quote":"You have or have ever had: … Heart, kidney or liver disease; Medical conditions such as seizures (fits), eating disorders … bipolar disorder, abnormally high or excited mood (mania) or schizophrenia … Bupropion may increase your blood pressure.","accessed":"2026-08-27"},{"id":"hh_bupro_side","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/bupropion","label":"HealthHub — Bupropion: common side effects","quote":"Nausea, vomiting or loss of appetite … Difficulty sleeping … Dry mouth … Constipation … Mild nervousness … Headache … Weight loss, sweating … Problems with eyesight","accessed":"2026-08-27"},{"id":"hh_bupro_serious","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/bupropion","label":"HealthHub — Bupropion: rare but serious side effects","quote":"Rarely this medication may cause: … signs and symptoms of liver problem … Strong feelings of agitation or anxiety … signs and symptoms of mania … Seizures (fits) … Fast, pounding or irregular heartbeat","accessed":"2026-08-27"},{"id":"hh_bupro_interactions","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/bupropion","label":"HealthHub — Bupropion: what food or medication should I avoid","quote":"Avoid drinking alcohol while taking Bupropion as it can worsen the symptoms of your depression and cause excessive sleepiness.","accessed":"2026-08-27"},{"id":"fda_wellbutrin_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22WELLBUTRIN+SR%22&limit=1","label":"US FDA label for WELLBUTRIN SR (bupropion hydrochloride), section 2 Dosage and Administration, via openFDA drug/label.json (effective 2025-11-05)","quote":"Maximum dose: 400 mg/day, given as 200 mg twice daily, for patients not responding to 300 mg/day … To avoid high peak concentrations of bupropion and/or its metabolites, do not exceed 200 mg in any single dose.","accessed":"2026-08-27"},{"id":"fda_wellbutrin_maoi","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22WELLBUTRIN+SR%22&limit=1","label":"US FDA label for WELLBUTRIN SR, sections 2.4–2.5 Switching to or from an MAOI, via openFDA drug/label.json (effective 2025-11-05)","quote":"At least 14 days should elapse between discontinuation of an MAOI … and initiation of therapy with WELLBUTRIN SR … Do not start WELLBUTRIN SR in a patient … being treated with a reversible MAOI such as linezolid","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:14.713299+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}