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Black seed oil

Supplement botanical oil immunegeneral nutrition
Aka: Nigella sativa, kalonji, habbatus sauda, black cumin
Brands seen in Singapore: Life Extension, Amazing Herbs, NOW Foods, Zhou Nutrition, Source Naturals
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
2016 review: fasting glucose fell in 13 of 23 trials
Pros & cons
Pros
  • 23 trials, 1,531 people pooled in one 2016 review
  • Fasting glucose and hba1c both fell in that pool
  • Immunity: igg rose in animals, not tested in humans
Cons
  • Blood pressure fell in 4 trials, not in 5
  • Lipid results were controversial across the trials
  • Liver-enzyme pooling was highly heterogeneous
Sources
  1. Mohtashami & Entezari, Effects of Nigella sativa supplementation on blood parameters and anthropometric indices in adults: a systematic review on clinical trials (J Res Med Sci 2016, PMID 27904549) — results · read 2026-08-27
    what it says
    “In 4 trials, N. sativa reduced BP, but in 5 trials it could not. Fasting blood sugar (FBS) was reduced significantly in 13 studies. In addition, N. sativa reduced levels of glycosylated hemoglobin (HbA1c).”
  2. Mohtashami & Entezari 2016 (PMID 27904549) — scope and conclusion · read 2026-08-27
    what it says
    “After analyzing 23 articles including 1531 participants … Our systematic review revealed that N. sativa supplementation might be effective in glycemic control in humans.”
  3. Mohtashami & Entezari 2016 (PMID 27904549) — anthropometry and lipids · read 2026-08-27
    what it says
    “Although weight and waist circumference (WC) in 2 articles were reduced significantly, in 6 articles they were not. Fluctuation in lipid profile in the articles was very controversial, being significant in many of them but not in others.”
  4. Azizi et al., The Effects of Nigella sativa Supplementation on Liver Enzymes Levels: a systematic review and meta-analysis of RCTs (Clin Nutr Res 2021, PMID 33564654) — scope and result · read 2026-08-27
    what it says
    “Eight studies met inclusion criteria (n=281 in the N. sativa and n = 279 in placebo group). This meta-analysis showed that N. sativa supplementation significantly reduced AST level … while the decrease in ALT level was not statistically significant”
  5. Azizi et al. 2021 (PMID 33564654) — heterogeneity and authors' caveat · read 2026-08-27
    what it says
    “significant heterogeneity (I-squared, 95.9%) … (I-squared, 97.8%) … more RCTs with larger sample size are needed to found effects of N. sativa on liver enzymes”
  6. Alsalahi et al., Immune stimulatory effect of Nigella sativa in healthy animal models: a systematic review and meta-analysis (Heliyon 2024, PMID 38510007) · read 2026-08-27
    what it says
    “Seventeen animal studies were eligible for analysis … NSS significantly increased serum titers of IgG and anti-SRBC antibodies … In conclusion, black seeds enhance humoral immunity in healthy animals but do not affect cellular immunity.”
  7. HSA Singapore — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (October 2025), Annex A (118 rows) and Annex B (4 rows) — Nigella sativa / black seed NOT LISTED in either (Annex A neighbours: 71. Mucuna, 74. Nicotinana) · read 2026-08-27
    what it says
    “The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.”
  8. HSA Singapore — Health Supplements Guidelines GL-CHPB-3-001 Rev. No. 020 (January 2026), clause 4.8 with Tables 4–5 (vitamins and minerals only — no botanical or bee-product rows) · read 2026-08-27
    what it says
    “4.8 HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.”
  9. iHerb Singapore — Black Seed Oil category page, default listing order · read 2026-08-27
    what it says
    “1 - 48 of 80 results … Life Extension, Black Cumin Seed Oil … Amazing Herbs, Premium Black Seed™ … NOW Foods, Black Cumin Seed Oil … Zhou Nutrition, Organic Black Seed Oil … Source Naturals, Black Seed Oil”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.