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Beta-glucan

Supplement polysaccharide immuneheart & metabolic
Aka: oat beta-glucan, yeast beta-glucan, 1,3/1,6 beta-glucan
Brands seen in Singapore: California Gold Nutrition, NOW Foods, Futurebiotics, Nutricost, Life Extension
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Oat beta-glucan lowers LDL and total cholesterol
Take with
As food — the FDA claim covers whole oat and barley foods
Studied for
Duration mattered in the meta-analysis subgroup results
Pros & cons
Pros
  • Meta-analysis: LDL fell 0.27 mmol/l across 13 trials
  • FDA claim cites 3 g a day of oat or barley beta-glucan
  • Yeast beta-glucan 204 mg cut cold-symptom severity
Cons
  • No effect on triglycerides or HDL in that meta-analysis
  • Oat and yeast beta-glucans are studied separately
  • The 120 mg yeast dose missed the clinical threshold
Sources
  1. Effects of Oat Beta-Glucan Intake on Lipid Profiles in Hypercholesterolemic Adults: Systematic Review and Meta-Analysis of RCTs (Yu et al., Nutrients 2022) · read 2026-08-27
    what it says
    “thirteen trials with 927 participants were included … oat beta-glucan supplementation significantly reduced levels of TC … LDL-c (pooled WMD = -0.27 mmol/L) … did not show significant effects on TG … HDL-c”
  2. Low-dose yeast beta-glucan on respiratory symptoms and psychological well-being in moderately stressed adults (iScience, 2026) · read 2026-08-27
    what it says
    “Both YBG doses improved symptoms compared with placebo … with only 204 mg exceeding the minimal clinically important difference. Both doses reduced negative mood states … with no safety concerns observed”
  3. US FDA authorized health claim, 21 CFR 101.81 — soluble fiber from certain foods and risk of coronary heart disease · read 2026-08-27
    what it says
    “3 g or more per day of β-glucan soluble fiber from either whole oats or barley, or a combination of whole oats and barley.”
  4. HSA Guidelines on prohibited and restricted ingredients in HS and TM (GL-CHPB-1-012, Oct 2025), s1.3 / Annex A · read 2026-08-27
    what it says
    “The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.”
  5. HSA Health Supplements Guidelines (GL-CHPB-3-001 Rev. 020, Jan 2026), s8.1 · read 2026-08-27
    what it says
    “Currently, HS are not subject to premarket approval and licensing by HSA for their importation, manufacture and sales in Singapore.”
  6. iHerb Singapore — Beta-Glucan category (default best-selling order) · read 2026-08-27
    what it says
    “California Gold Nutrition … NOW Foods … Futurebiotics … Nutricost … Life Extension”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.