{"ok":true,"entry":{"slug":"beta-glucan","kind":"supplement","name":"beta-glucan","aliases":["oat beta-glucan","yeast beta-glucan","1,3/1,6 beta-glucan"],"brands_sg":["California Gold Nutrition","NOW Foods","Futurebiotics","Nutricost","Life Extension"],"class":"polysaccharide","tags":["immune","heart"],"use_for":"oat beta-glucan lowers ldl and total cholesterol","use_after":null,"use_duration":"duration mattered in the meta-analysis subgroup results","take_with":"as food — the fda claim covers whole oat and barley foods","pros":["meta-analysis: ldl fell 0.27 mmol/l across 13 trials","fda claim cites 3 g a day of oat or barley beta-glucan","yeast beta-glucan 204 mg cut cold-symptom severity"],"cons":["no effect on triglycerides or hdl in that meta-analysis","oat and yeast beta-glucans are studied separately","the 120 mg yeast dose missed the clinical threshold"],"dose_note":"the fda claim cites 3 g or more a day of oat or barley beta-glucan; a yeast beta-glucan trial used 120 or 204 mg a day","dosage":{"ul":null,"unit":"g","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["oat/barley and yeast beta-glucans are different molecules — evidence does not transfer between them","not named in hsa's prohibited/restricted annex — that list is not exhaustive","hsa does not approve health supplements before sale in singapore"],"clashes":[],"sources":[{"id":"yu2022","url":"https://europepmc.org/article/PMC/PMC9147392","label":"Effects of Oat Beta-Glucan Intake on Lipid Profiles in Hypercholesterolemic Adults: Systematic Review and Meta-Analysis of RCTs (Yu et al., Nutrients 2022)","quote":"thirteen trials with 927 participants were included … oat beta-glucan supplementation significantly reduced levels of TC … LDL-c (pooled WMD = -0.27 mmol/L) … did not show significant effects on TG … HDL-c","accessed":"2026-08-27"},{"id":"ybg2026","url":"https://europepmc.org/article/PMC/PMC13010125","label":"Low-dose yeast beta-glucan on respiratory symptoms and psychological well-being in moderately stressed adults (iScience, 2026)","quote":"Both YBG doses improved symptoms compared with placebo … with only 204 mg exceeding the minimal clinically important difference. Both doses reduced negative mood states … with no safety concerns observed","accessed":"2026-08-27"},{"id":"fda_cfr","url":"https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-101/subpart-E/section-101.81","label":"US FDA authorized health claim, 21 CFR 101.81 — soluble fiber from certain foods and risk of coronary heart disease","quote":"3 g or more per day of β-glucan soluble fiber from either whole oats or barley, or a combination of whole oats and barley.","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA Guidelines on prohibited and restricted ingredients in HS and TM (GL-CHPB-1-012, Oct 2025), s1.3 / Annex A","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA Health Supplements Guidelines (GL-CHPB-3-001 Rev. 020, Jan 2026), s8.1","quote":"Currently, HS are not subject to premarket approval and licensing by HSA for their importation, manufacture and sales in Singapore.","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/beta-glucan","label":"iHerb Singapore — Beta-Glucan category (default best-selling order)","quote":"California Gold Nutrition … NOW Foods … Futurebiotics … Nutricost … Life Extension","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:12.75901+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}