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Artichoke extract

Supplement botanical gutheart & metabolic
Aka: Cynara scolymus, cynarin
Brands seen in Singapore: California Gold Nutrition, Micro Ingredients, NOW Foods, Nature's Way, Nutricost
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Dyspepsia symptoms — one trial, low-certainty evidence
Pros & cons
Pros
  • Cochrane: may improve dyspepsia vs placebo
  • Ema: traditional herbal use for digestive upset
  • A 2021 meta-analysis of 14 trials saw LDL-c fall
Cons
  • Cochrane rated that evidence low certainty
  • It rests on 1 trial of 244 people, smd −0.34
  • SG bars cholesterol claims (HSA table 6)
Sources
  1. Non-Chinese herbal medicines for functional dyspepsia (Báez, Vargas, Arancibia, Papuzinski & Franco; Cochrane Database of Systematic Reviews 2023) — artichoke result · read 2026-08-27
    what it says
    “We found evidence that the following herbal medicines may improve symptoms of dyspepsia compared to placebo … artichoke (SMD -0.34, 95% CI -0.59 to -0.09; 1 study, 244 participants; low CoE)”
  2. Cochrane 2023, Non-Chinese herbal medicines for functional dyspepsia — authors' conclusions · read 2026-08-27
    what it says
    “Based on moderate to very low-certainty evidence, we identified some herbal medicines that may be effective in improving symptoms of dyspepsia. Moreover, these interventions may not be associated with important adverse events.”
  3. Medicinal Plants in Food Supplements for Gastrointestinal Disorders (Teterovska et al., Nutrients 2025) — section 3.3.2, EMA status of artichoke · read 2026-08-27
    what it says
    “The EMA has classified artichoke as a traditional herbal medicinal product for the symptomatic relief of digestive disorders, such as dyspepsia accompanied by a sensation of fullness, bloating, and flatulence, based on long-standing use”
  4. Teterovska et al., Nutrients 2025 — section 3.3.2, doses used in trials versus doses sold · read 2026-08-27
    what it says
    “Standardized artichoke leaf extracts 320 or 640 mg daily used for 2 months reduced mild dyspepsia … Most clinical studies used 320 mg once or twice per day; thus, FS doses under 320 mg might be insufficient”
  5. Teterovska et al., Nutrients 2025 — section 3.3.2, doses found in marketed food supplements · read 2026-08-27
    what it says
    “Most products contained artichoke leaf extract, and doses ranged significantly from 15 to 2500 mg per dosage.”
  6. Effects of artichoke leaf extract supplementation or artichoke juice consumption on lipid profile: a systematic review and dose-response meta-analysis of RCTs (Shahinfar et al., Phytotherapy Research 2021) · read 2026-08-27
    what it says
    “Combining 15 effect sizes from 14 studies … artichoke significantly reduced TG …, TC …, and LDL-C (WMD: -17.48 mg/dl, 95%CI: -25.44, -9.53, p < .001). No significant effect of artichoke on HDL-C level was detected”
  7. HSA Singapore — Health Supplements Guidelines GL-CHPB-3-001 Rev. No. 020 (January 2026), clause 6.6 and Table 6 (diseases/conditions not allowed for health supplements) · read 2026-08-27
    what it says
    “HS must not be labelled, advertised or promoted for any specific medicinal purpose … Blood and circulatory system: Hypertension, stroke, cholesterol disorders, reduces cholesterol, regulates platelet aggregation, coagulation defects, arteriosclerosis”
  8. HSA Singapore — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (October 2025), Annex A (118 rows) and Annex B (4 rows) — artichoke / Cynara scolymus not listed in either (alphabetical neighbours 36. Croton tiglium, 37. Danthron) · read 2026-08-27
    what it says
    “The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.”
  9. HSA Singapore — Health Supplements Guidelines GL-CHPB-3-001 Rev. No. 020 (January 2026), clause 4.8 with Tables 4–5 (vitamins and minerals only — no botanical rows) · read 2026-08-27
    what it says
    “4.8 HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.”
  10. iHerb Singapore — Artichoke category page, default listing order · read 2026-08-27
    what it says
    “1 - 22 of 22 results: California Gold Nutrition, Silymarin Complex; Micro Ingredients, TUDCA; NOW Foods, Artichoke Extract; Nature's Way, Artichoke, Standardized Extract; Nutricost, Artichoke Extract, 600 mg”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.