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Apixaban

Medication direct oral anticoagulant heart & blood pressure
Aka: Eliquis
Brands seen in Singapore: Eliquis, Hemapix, Apigat
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Prescribed to prevent and treat blood clots
When to take
HealthHub: two times a day, at the SAMe time each day
Take with
Water · NHS: with or without food
Pros & cons
Pros
  • NHS: with or without food, usually twice a day
  • NHS: tablets can be crushed if swallowing is hard
  • HealthHub: no drastic lifestyle changes needed
Cons
  • NHS: bleeding and bruising more easily than usual
  • FDA: boxed warning on spinal or epidural haematoma
  • FDA: stopping early raises the risk of clots
Sources
  1. HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally) · read 2026-08-27
    what it says
    “All 6 registered apixaban products read Forensicclassification 'Prescription Only' — SIN14279P Eliquis Tablet 2.5mg · SIN14407P ELIQUIS TABLET 5MG · SIN17320P/SIN17321P HEMAPIX · SIN17430P/SIN17431P APIGAT, ATC B01AF02.”
  2. NHS Medicines A-Z — Apixaban: what apixaban is for · read 2026-08-27
    what it says
    “Apixaban is a medicine used to help prevent blood clots. You might have it after surgery or to treat a condition. It's only available with a prescription … a medicine called an anticoagulant.”
  3. NHS Medicines A-Z — Apixaban: how to take apixaban · read 2026-08-27
    what it says
    “It's usually taken twice a day … you can take it with or without food … If you have problems swallowing tablets, you can crush the tablets and mix them with water, apple juice or apple purée.”
  4. NHS Medicines A-Z — Apixaban: side effects · read 2026-08-27
    what it says
    “One of the most common side effects of taking apixaban is bleeding more than usual … nosebleeds; bleeding from your gums when you brush your teeth; bruises that come up more easily … periods that are heavier”
  5. NHS Medicines A-Z — Apixaban: who can and cannot take it · read 2026-08-27
    what it says
    “you have a condition that increases your risk of serious bleeding, such as a stomach or bowel ulcer; you've recently had a bleed in your brain; you have liver or kidney disease; you're pregnant or breastfeeding”
  6. NHS Medicines A-Z — Apixaban: taking it with other medicines · read 2026-08-27
    what it says
    “other medicines that prevent blood clots (anticoagulants), such as warfarin; medicines for fungal infections … antidepressant medicines, such as SSRIs; painkillers or anti-inflammatories (NSAIDs); the herbal remedy for low mood, St John's Wort; HIV medicines”
  7. HealthHub (Pharmaceutical Society of Singapore) — Apixaban: what is this medication for · read 2026-08-27
    what it says
    “Apixaban is a blood thinning medication that prevents blood clots from forming in your body. It does not remove clots that are already formed, but prevents these clots from becoming bigger.”
  8. HealthHub — Apixaban: how should I take this medication · read 2026-08-27
    what it says
    “This medication should be taken two times a day. You may take this medication with or without food. If you are unable to swallow the tablets whole, you may crush the tablets and mix with water immediately before taking it.”
  9. HealthHub — Apixaban: what precautions should I take · read 2026-08-27
    what it says
    “There is no need to make drastic changes to your lifestyle. However, avoid sports or activities that may cause you to get injured … Inform all doctors, dentists and pharmacists that you are on Apixaban.”
  10. HealthHub — Apixaban: what food or medication should I avoid · read 2026-08-27
    what it says
    “Examples of medications or supplements that may affect Apixaban: Antibiotics for tuberculosis (e.g. Rifampicin); Medications to treat fungal infections (e.g. Itraconazole); Seizure medications (e.g. Carbamazepine, Phenytoin); St John's Wort”
  11. US FDA label — ELIQUIS (apixaban), section 2 Dosage and Administration, via openFDA drug/label.json · read 2026-08-27
    what it says
    “The recommended dose of ELIQUIS for most patients is 5 mg taken orally twice daily … The recommended dose of ELIQUIS is 2.5 mg twice daily in patients with at least two of the following characteristics:”
  12. US FDA label — ELIQUIS (apixaban), boxed warning, via openFDA drug/label.json · read 2026-08-27
    what it says
    “(A) PREMATURE DISCONTINUATION OF ELIQUIS INCREASES THE RISK OF THROMBOTIC EVENTS … Epidural or spinal hematomas may occur in patients treated with ELIQUIS who are receiving neuraxial anesthesia or undergoing spinal puncture.”
  13. US FDA label — ELIQUIS (apixaban), section 4 Contraindications, via openFDA drug/label.json · read 2026-08-27
    what it says
    “ELIQUIS is contraindicated in patients with the following conditions: Active pathological bleeding; Severe hypersensitivity reaction to ELIQUIS (e.g., anaphylactic reactions)”
  14. US FDA label — ELIQUIS (apixaban), section 7 Drug Interactions, via openFDA drug/label.json · read 2026-08-27
    what it says
    “Inhibitors of CYP3A4 and P-gp increase exposure to apixaban and increase the risk of bleeding. Inducers of CYP3A4 and P-gp decrease exposure to apixaban and increase the risk of stroke … Avoid concomitant use.”
  15. US FDA label — ELIQUIS (apixaban), section 2.1 dose-reduction criteria, via openFDA drug/label.json · read 2026-08-27
    what it says
    “age greater than or equal to 80 years; body weight less than or equal to 60 kg; serum creatinine greater than or equal to 1.5 mg/dL”
  16. US FDA label — ELIQUIS (apixaban), section 2.1 treatment of DVT and PE, via openFDA drug/label.json · read 2026-08-27
    what it says
    “Treatment of DVT and PE: The recommended dose is 10 mg taken orally twice daily for 7 days, followed by 5 mg taken orally twice daily.”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.