{"ok":true,"entry":{"slug":"apixaban","kind":"medication","name":"apixaban","aliases":["Eliquis"],"brands_sg":["Eliquis","Hemapix","Apigat"],"class":"direct oral anticoagulant","tags":["heart-bp"],"use_for":"prescribed to prevent and treat blood clots","use_after":"healthhub: two times a day, at the same time each day","use_duration":null,"take_with":"water · nhs: with or without food","pros":["nhs: with or without food, usually twice a day","nhs: tablets can be crushed if swallowing is hard","healthhub: no drastic lifestyle changes needed"],"cons":["nhs: bleeding and bruising more easily than usual","fda: boxed warning on spinal or epidural haematoma","fda: stopping early raises the risk of clots"],"dose_note":"the us fda label for eliquis gives 5 mg twice daily for most people with nonvalvular atrial fibrillation, 2.5 mg twice daily where at least two of age ≥80, weight ≤60 kg or serum creatinine ≥1.5 mg/dl apply, and '10 mg taken orally twice daily for the first 7 days of therapy' when treating dvt and pe — 10 mg twice daily is the highest figure the label carries. sg-registered strengths are 2.5 mg and 5 mg tablets. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["a bleeding condition, ulcer or brain bleed (nhs)","liver or kidney disease (nhs)","pregnancy or breastfeeding — nhs: not used","fda: contraindicated in active pathological bleeding"],"clashes":[{"src":["nhs_apix_mix"],"note":"nhs lists other clot-preventing medicines among poor mixes","with":"other anticoagulants such as warfarin"},{"src":["nhs_apix_mix"],"note":"nhs lists painkillers or anti-inflammatories among poor mixes","with":"nsaids and anti-inflammatory painkillers"},{"src":["nhs_apix_mix"],"note":"nhs lists antidepressant medicines such as ssris among poor mixes","with":"ssri antidepressants"},{"src":["fda_apix_di"],"note":"fda: combined p-gp and strong cyp3a4 inhibitors raise apixaban levels and bleeding risk","with":"ketoconazole, itraconazole, ritonavir"},{"src":["hh_apix_food","fda_apix_di"],"note":"healthhub and fda: strong inducers lower apixaban levels; fda: avoid concomitant use","with":"rifampicin, carbamazepine, phenytoin, st john's wort"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally)","quote":"All 6 registered apixaban products read Forensicclassification 'Prescription Only' — SIN14279P Eliquis Tablet 2.5mg · SIN14407P ELIQUIS TABLET 5MG · SIN17320P/SIN17321P HEMAPIX · SIN17430P/SIN17431P APIGAT, ATC B01AF02.","accessed":"2026-08-27"},{"id":"nhs_apix_about","url":"https://www.nhs.uk/medicines/apixaban/","label":"NHS Medicines A-Z — Apixaban: what apixaban is for","quote":"Apixaban is a medicine used to help prevent blood clots. You might have it after surgery or to treat a condition. It's only available with a prescription … a medicine called an anticoagulant.","accessed":"2026-08-27"},{"id":"nhs_apix_howto","url":"https://www.nhs.uk/medicines/apixaban/","label":"NHS Medicines A-Z — Apixaban: how to take apixaban","quote":"It's usually taken twice a day … you can take it with or without food … If you have problems swallowing tablets, you can crush the tablets and mix them with water, apple juice or apple purée.","accessed":"2026-08-27"},{"id":"nhs_apix_side","url":"https://www.nhs.uk/medicines/apixaban/","label":"NHS Medicines A-Z — Apixaban: side effects","quote":"One of the most common side effects of taking apixaban is bleeding more than usual … nosebleeds; bleeding from your gums when you brush your teeth; bruises that come up more easily … periods that are heavier","accessed":"2026-08-27"},{"id":"nhs_apix_who","url":"https://www.nhs.uk/medicines/apixaban/","label":"NHS Medicines A-Z — Apixaban: who can and cannot take it","quote":"you have a condition that increases your risk of serious bleeding, such as a stomach or bowel ulcer; you've recently had a bleed in your brain; you have liver or kidney disease; you're pregnant or breastfeeding","accessed":"2026-08-27"},{"id":"nhs_apix_mix","url":"https://www.nhs.uk/medicines/apixaban/","label":"NHS Medicines A-Z — Apixaban: taking it with other medicines","quote":"other medicines that prevent blood clots (anticoagulants), such as warfarin; medicines for fungal infections … antidepressant medicines, such as SSRIs; painkillers or anti-inflammatories (NSAIDs); the herbal remedy for low mood, St John's Wort; HIV medicines","accessed":"2026-08-27"},{"id":"hh_apix_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/apixaban","label":"HealthHub (Pharmaceutical Society of Singapore) — Apixaban: what is this medication for","quote":"Apixaban is a blood thinning medication that prevents blood clots from forming in your body. It does not remove clots that are already formed, but prevents these clots from becoming bigger.","accessed":"2026-08-27"},{"id":"hh_apix_howto","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/apixaban","label":"HealthHub — Apixaban: how should I take this medication","quote":"This medication should be taken two times a day. You may take this medication with or without food. If you are unable to swallow the tablets whole, you may crush the tablets and mix with water immediately before taking it.","accessed":"2026-08-27"},{"id":"hh_apix_prec","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/apixaban","label":"HealthHub — Apixaban: what precautions should I take","quote":"There is no need to make drastic changes to your lifestyle. However, avoid sports or activities that may cause you to get injured … Inform all doctors, dentists and pharmacists that you are on Apixaban.","accessed":"2026-08-27"},{"id":"hh_apix_food","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/apixaban","label":"HealthHub — Apixaban: what food or medication should I avoid","quote":"Examples of medications or supplements that may affect Apixaban: Antibiotics for tuberculosis (e.g. Rifampicin); Medications to treat fungal infections (e.g. Itraconazole); Seizure medications (e.g. Carbamazepine, Phenytoin); St John's Wort","accessed":"2026-08-27"},{"id":"fda_apix_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22apixaban%22&limit=3","label":"US FDA label — ELIQUIS (apixaban), section 2 Dosage and Administration, via openFDA drug/label.json","quote":"The recommended dose of ELIQUIS for most patients is 5 mg taken orally twice daily … The recommended dose of ELIQUIS is 2.5 mg twice daily in patients with at least two of the following characteristics:","accessed":"2026-08-27"},{"id":"fda_apix_boxed","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22apixaban%22&limit=3","label":"US FDA label — ELIQUIS (apixaban), boxed warning, via openFDA drug/label.json","quote":"(A) PREMATURE DISCONTINUATION OF ELIQUIS INCREASES THE RISK OF THROMBOTIC EVENTS … Epidural or spinal hematomas may occur in patients treated with ELIQUIS who are receiving neuraxial anesthesia or undergoing spinal puncture.","accessed":"2026-08-27"},{"id":"fda_apix_ci","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22apixaban%22&limit=3","label":"US FDA label — ELIQUIS (apixaban), section 4 Contraindications, via openFDA drug/label.json","quote":"ELIQUIS is contraindicated in patients with the following conditions: Active pathological bleeding; Severe hypersensitivity reaction to ELIQUIS (e.g., anaphylactic reactions)","accessed":"2026-08-27"},{"id":"fda_apix_di","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22apixaban%22&limit=3","label":"US FDA label — ELIQUIS (apixaban), section 7 Drug Interactions, via openFDA drug/label.json","quote":"Inhibitors of CYP3A4 and P-gp increase exposure to apixaban and increase the risk of bleeding. Inducers of CYP3A4 and P-gp decrease exposure to apixaban and increase the risk of stroke … Avoid concomitant use.","accessed":"2026-08-27"},{"id":"fda_apix_dose_crit","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22apixaban%22&limit=3","label":"US FDA label — ELIQUIS (apixaban), section 2.1 dose-reduction criteria, via openFDA drug/label.json","quote":"age greater than or equal to 80 years; body weight less than or equal to 60 kg; serum creatinine greater than or equal to 1.5 mg/dL","accessed":"2026-08-27"},{"id":"fda_apix_dose_dvt","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22apixaban%22&limit=3","label":"US FDA label — ELIQUIS (apixaban), section 2.1 treatment of DVT and PE, via openFDA drug/label.json","quote":"Treatment of DVT and PE: The recommended dose is 10 mg taken orally twice daily for 7 days, followed by 5 mg taken orally twice daily.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:10.48466+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}