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Apigenin

Supplement flavonoid sleepbrain & mood
Aka: chamomile flavone
Brands seen in Singapore: California Gold Nutrition, Nutricost, Swanson Vitamins, Codeage, Vitamatic
Third-party tested: Codeage certifies other products with NSF Certified for Sport, but nothing for apigenin.Certification is granted per product, so check the tub you actually own. Not being listed is not the same as failing.
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Limited human evidence — chamomile is what trials test
Pros & cons
Pros
  • One RCT used 400 mg chamomile at 1.2% apigenin
  • Not named in HSA's prohibited or restricted annexes
Cons
  • NCCIH: one insomnia study found no benefit
  • Trials test chamomile extract, not isolated apigenin
  • No RDA, no upper limit, no SG cap set
Sources
  1. NIH NCCIH — Chamomile: Usefulness and Safety · read 2026-08-27
    what it says
    “There's very little information on chamomile's effect on insomnia. A 2019 review of chamomile use found one study on insomnia, which found no benefit from its use for this sleep disorder.”
  2. Effect of Matricaria chamomilla on Quality of Life Among Women with Menopausal Symptoms: Triple-Blind RCT (J Integr Complement Med 2026) · read 2026-08-27
    what it says
    “80 postmenopausal women aged 47-62 years were randomly assigned to receive either 400 mg Chamomile capsules daily (standardized to 1.2% apigenin) or placebo for 12 weeks”
  3. Effectiveness of Lesser Known Herbal Sedatives for Insomnia: Systematic Review and Meta-Analysis (2026) — PREPRINT, not peer-reviewed · read 2026-08-27
    what it says
    “Subgroup analysis showed larger effects for chamomile (SMD −1.06) … Most RCTs had high overall risk of bias … substantial heterogeneity (I²=92%)”
  4. HSA — Guidelines on prohibited and restricted ingredients in health supplements and traditional medicines (Oct 2025), Annexes A and B · read 2026-08-27
    what it says
    “Annex A: List of substances which are prohibited or restricted for use with conditions … Annex B: List of substances with potential safety issues [apigenin appears in neither annex]”
  5. HSA — Health Supplements Guidelines (Jan 2026), Tables 4–5 vitamin and mineral limits · read 2026-08-27
    what it says
    “Table 4: Vitamins Limits … Table 5: Minerals Limits [neither table names apigenin]”
  6. iHerb Singapore — Apigenin category page (Supplements > Herbs), default order · read 2026-08-27
    what it says
    “Nutricost, Apigenin, 50 mg, 180 Capsules … Swanson Vitamins, Apigenin, 50 mg, 90 Capsules … Codeage, Liposomal Apigenin, Phospholipid Complex, 90 Vegetable Capsules”
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Updated 2026-08-30. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.