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Amitriptyline

Medication tricyclic antidepressant mental health
Aka: Tryptanol
Brands seen in Singapore: Apo-Amitriptyline
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Depression · HealthHub notes other uses as well
When to take
HealthHub: full benefit takes a few weeks of regular use
Take with
With or without food · alcohol adds to the drowsiness
Pros & cons
Pros
  • HealthHub: an established tricyclic antidepressant
  • HealthHub: taken with or without food
  • 10 and 25 mg are the SG registered strengths
Cons
  • Dry mouth, constipation and drowsiness are common
  • HealthHub: weight gain and lower sex drive are reported
  • Under 25 — self-harm thoughts can worsen early on
Sources
  1. HSA — Listing of Registered Therapeutic Products (data.gov.sg d_767279312753558cbf19d48344577084), Forensicclassification column; cached at /tmp/hsa_all.json and filtered locally, not re-fetched · read 2026-08-27
    what it says
    “APO-AMITRIPTYLINE TABLET 25 mg SIN00090P | AMITRIPTYLINE HCl | Prescription Only | N06AA09; APO-AMITRIPTYLINE TABLET 10 mg SIN00089P | AMITRIPTYLINE HCl | Prescription Only | N06AA09 — the only 2 amitriptyline rows in the register, both Prescription Only”
  2. MOH National Drug Formulary (Singapore) — APO-AMITRIPTYLINE TABLET 25 mg [SIN00090P], product information (no indication or dosing section is published for this product) · read 2026-08-27
    what it says
    “AMITRIPTYLINE HCL - 25 MG … Forensic Classification PRESCRIPTION ONLY MEDICINES … Anatomical Therapeutic Chemical (ATC) code N06AA09 … Prescription-only Medicines with Exemptions for Supply without Prescription NA”
  3. HealthHub (MOH Singapore) — Amitriptyline, medication information leaflet · read 2026-08-27
    what it says
    “Amitriptyline belongs to a class of medications known as Tricyclic antidepressants (TCA). It is used to treat symptoms of depression … Amitriptyline may also be used for other conditions.”
  4. HealthHub (MOH Singapore) — Amitriptyline, how to take it · read 2026-08-27
    what it says
    “Amitriptyline may be taken with or without food … Amitriptyline needs to be taken regularly for a few weeks before you can feel its full benefits.”
  5. HealthHub (MOH Singapore) — Amitriptyline, precautions · read 2026-08-27
    what it says
    “Heart, kidney or liver disease Medical conditions such as difficulty in urination, enlarged prostate gland, overactive thyroid gland (hyperthyroidism), seizures (fits), Parkinson’s disease, increased eye pressure (glauco ma), or diabetes”
  6. HealthHub (MOH Singapore) — Amitriptyline, common side effects · read 2026-08-27
    what it says
    “Nausea, vomiting or loss of appetite … Drowsiness or feeling tired … Dry mouth … Constipation … Dizziness … Weight gain … Headache, decreased sexual drive or ability”
  7. HealthHub (MOH Singapore) — Amitriptyline, food and medication to avoid · read 2026-08-27
    what it says
    “Avoid drinking alcohol while taking Amitriptyline as it can worsen the symptoms of your depression and cause excessive sleepiness.”
  8. NHS medicines A–Z — Amitriptyline for depression, taking it with other medicines and herbal supplements (reviewed 28 February 2025) · read 2026-08-27
    what it says
    “Taking amitriptyline with opioid medicines can increase your risk of becoming very drowsy and having breathing problems … Some antidepressants can affect the way amitriptyline works and can cause very high blood pressure … Do not take St John's wort”
  9. US FDA label — Amitriptyline Hydrochloride tablets, A-S Medication Solutions, effective 2024-06-12, Dosage and Administration, via openFDA · read 2026-08-27
    what it says
    “For outpatients, 75 mg of amitriptyline hydrochloride a day in divided doses is usually satisfactory. If necessary, this may be increased to a total of 150 mg per day”
  10. US FDA label — Amitriptyline Hydrochloride tablets, A-S Medication Solutions, effective 2024-06-12, Dosage and Administration: hospitalised patients, via openFDA · read 2026-08-27
    what it says
    “Hospitalized patients may require 100 mg a day initially. This can be increased gradually to 200 mg a day if necessary. A small number of hospitalized patients may need as much as 300 mg a day.”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.