{"ok":true,"entry":{"slug":"amitriptyline","kind":"medication","name":"amitriptyline","aliases":["Tryptanol"],"brands_sg":["Apo-Amitriptyline"],"class":"tricyclic antidepressant","tags":["mental-health"],"use_for":"depression · healthhub notes other uses as well","use_after":"healthhub: full benefit takes a few weeks of regular use","use_duration":null,"take_with":"with or without food · alcohol adds to the drowsiness","pros":["healthhub: an established tricyclic antidepressant","healthhub: taken with or without food","10 and 25 mg are the sg registered strengths"],"cons":["dry mouth, constipation and drowsiness are common","healthhub: weight gain and lower sex drive are reported","under 25 — self-harm thoughts can worsen early on"],"dose_note":"no sg dosing is published for apo-amitriptyline, the only amitriptyline registered here, so the ceiling below is from the us label: \"For outpatients, 75 mg of amitriptyline hydrochloride a day in divided doses is usually satisfactory. If necessary, this may be increased to a total of 150 mg per day\", while \"Hospitalized patients may require 100 mg a day initially. This can be increased gradually to 200 mg a day if necessary. A small number of hospitalized patients may need as much as 300 mg a day\" — as directed on the label or by your doctor","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["heart, kidney or liver disease — healthhub asks that these be declared before starting","glaucoma, difficulty passing urine, an enlarged prostate, seizures, parkinson's disease, an overactive thyroid or diabetes — healthhub precautions","bipolar disorder, mania or alcohol misuse, and any antidepressant taken in the past 2 weeks — healthhub precautions","under 25 — healthhub flags new or worsening thoughts of self-harm, agitation or mood change in the first few weeks"],"clashes":[{"src":["nhs_amitriptyline_int"],"note":"nhs: raises the risk of becoming very drowsy and having breathing problems","with":"opioid painkillers such as codeine, morphine or oxycodone"},{"src":["nhs_amitriptyline_int"],"note":"nhs: some can affect how amitriptyline works and cause very high blood pressure, even after they are stopped","with":"other antidepressants"},{"src":["nhs_amitriptyline_int","hh_amitriptyline_prec"],"note":"nhs: not to be taken with amitriptyline as it increases the risk of side effects; healthhub also names it","with":"st john's wort"},{"src":["hh_amitriptyline_food"],"food":true,"note":"healthhub: can worsen the symptoms of depression and cause excessive sleepiness","with":"alcohol"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/api/action/datastore_search?resource_id=d_767279312753558cbf19d48344577084&limit=6000","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg d_767279312753558cbf19d48344577084), Forensicclassification column; cached at /tmp/hsa_all.json and filtered locally, not re-fetched","quote":"APO-AMITRIPTYLINE TABLET 25 mg SIN00090P | AMITRIPTYLINE HCl | Prescription Only | N06AA09; APO-AMITRIPTYLINE TABLET 10 mg SIN00089P | AMITRIPTYLINE HCl | Prescription Only | N06AA09 — the only 2 amitriptyline rows in the register, both Prescription Only","accessed":"2026-08-27"},{"id":"ndf_apo_amitriptyline","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin00090p/","label":"MOH National Drug Formulary (Singapore) — APO-AMITRIPTYLINE TABLET 25 mg [SIN00090P], product information (no indication or dosing section is published for this product)","quote":"AMITRIPTYLINE HCL - 25 MG … Forensic Classification PRESCRIPTION ONLY MEDICINES … Anatomical Therapeutic Chemical (ATC) code N06AA09 … Prescription-only Medicines with Exemptions for Supply without Prescription NA","accessed":"2026-08-27"},{"id":"hh_amitriptyline","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/amitriptyline","label":"HealthHub (MOH Singapore) — Amitriptyline, medication information leaflet","quote":"Amitriptyline belongs to a class of medications known as Tricyclic antidepressants (TCA). It is used to treat symptoms of depression … Amitriptyline may also be used for other conditions.","accessed":"2026-08-27"},{"id":"hh_amitriptyline_admin","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/amitriptyline","label":"HealthHub (MOH Singapore) — Amitriptyline, how to take it","quote":"Amitriptyline may be taken with or without food … Amitriptyline needs to be taken regularly for a few weeks before you can feel its full benefits.","accessed":"2026-08-27"},{"id":"hh_amitriptyline_prec","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/amitriptyline","label":"HealthHub (MOH Singapore) — Amitriptyline, precautions","quote":"Heart, kidney or liver disease Medical conditions such as difficulty in urination, enlarged prostate gland, overactive thyroid gland (hyperthyroidism), seizures (fits), Parkinson’s disease, increased eye pressure (glauco ma), or diabetes","accessed":"2026-08-27"},{"id":"hh_amitriptyline_se","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/amitriptyline","label":"HealthHub (MOH Singapore) — Amitriptyline, common side effects","quote":"Nausea, vomiting or loss of appetite … Drowsiness or feeling tired … Dry mouth … Constipation … Dizziness … Weight gain … Headache, decreased sexual drive or ability","accessed":"2026-08-27"},{"id":"hh_amitriptyline_food","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/amitriptyline","label":"HealthHub (MOH Singapore) — Amitriptyline, food and medication to avoid","quote":"Avoid drinking alcohol while taking Amitriptyline as it can worsen the symptoms of your depression and cause excessive sleepiness.","accessed":"2026-08-27"},{"id":"nhs_amitriptyline_int","url":"https://www.nhs.uk/medicines/amitriptyline-for-depression/taking-amitriptyline-for-depression-with-other-medicines-and-herbal-supplements/","label":"NHS medicines A–Z — Amitriptyline for depression, taking it with other medicines and herbal supplements (reviewed 28 February 2025)","quote":"Taking amitriptyline with opioid medicines can increase your risk of becoming very drowsy and having breathing problems … Some antidepressants can affect the way amitriptyline works and can cause very high blood pressure … Do not take St John's wort","accessed":"2026-08-27"},{"id":"fda_amitriptyline_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22AMITRIPTYLINE+HYDROCHLORIDE%22&limit=2","label":"US FDA label — Amitriptyline Hydrochloride tablets, A-S Medication Solutions, effective 2024-06-12, Dosage and Administration, via openFDA","quote":"For outpatients, 75 mg of amitriptyline hydrochloride a day in divided doses is usually satisfactory. If necessary, this may be increased to a total of 150 mg per day","accessed":"2026-08-27"},{"id":"fda_amitriptyline_dose2","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22AMITRIPTYLINE+HYDROCHLORIDE%22&limit=2","label":"US FDA label — Amitriptyline Hydrochloride tablets, A-S Medication Solutions, effective 2024-06-12, Dosage and Administration: hospitalised patients, via openFDA","quote":"Hospitalized patients may require 100 mg a day initially. This can be increased gradually to 200 mg a day if necessary. A small number of hospitalized patients may need as much as 300 mg a day.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:10.48466+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}