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Agmatine

Supplement amino acid derivative general nutrition
Aka: agmatine sulfate
Brands seen in Singapore: California Gold Nutrition, Nutricost, EVLution Nutrition, Vitamatic, Primaforce
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Limited human evidence — studied mainly in animal models
Pros & cons
Pros
  • 60 studies pooled in a 2025 cardiovascular review
  • Not listed on HSA's prohibited/restricted annex
Cons
  • Human performance evidence is essentially absent
  • Blood pressure moved both ways across studies
  • Not being listed by HSA is not a safety clearance
Sources
  1. Exploring the Cardiovascular Impacts of Agmatine: A Systematic Review (Manole et al., Med Sci 2025) · read 2026-08-27
    what it says
    “Because AG is primarily explored in experimental medicine, the majority of the research was preclinical studies … AG has demonstrated dual effects—an increase or decrease in blood pressure or in heart rate”
  2. HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines (Oct 2025), Annex A · read 2026-08-27
    what it says
    “A list of specific prohibited and restricted ingredients is provided in Annex A … This list is not exhaustive. Dealers are responsible to ensure that their products are safe and appropriate for the target consumers.”
  3. HSA — Health Supplements Guidelines (Jan 2026), Tables 4–5 · read 2026-08-27
    what it says
    “HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.”
  4. iHerb Singapore — Agmatine Sulfate category page (Sports > Nitric Oxide Supplements), default order · read 2026-08-27
    what it says
    “California Gold Nutrition, Sport, Agmatine Sulfate, Unflavored, 3.5 oz (100 g) … Nutricost, Agmatine Sulfate, 120 Capsules (500 mg per Capsule)”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.