{"ok":true,"entry":{"slug":"agmatine","kind":"supplement","name":"agmatine","aliases":["agmatine sulfate"],"brands_sg":["California Gold Nutrition","Nutricost","EVLution Nutrition","Vitamatic","Primaforce"],"class":"amino acid derivative","tags":["general"],"use_for":"limited human evidence — studied mainly in animal models","use_after":null,"use_duration":null,"take_with":null,"pros":["60 studies pooled in a 2025 cardiovascular review","not listed on HSA's prohibited/restricted annex"],"cons":["human performance evidence is essentially absent","blood pressure moved both ways across studies","not being listed by HSA is not a safety clearance"],"dose_note":null,"dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["blood pressure medicines — preclinical effects cut both ways","heart rhythm conditions — altered pacemaker firing in tissue"],"clashes":[{"src":["manole2025"],"note":"preclinical work shows agmatine raising or lowering blood pressure depending on dose and route; no human supplement data","with":"blood-pressure medicines"}],"sources":[{"id":"manole2025","url":"https://europepmc.org/article/PMC/PMC12641643","label":"Exploring the Cardiovascular Impacts of Agmatine: A Systematic Review (Manole et al., Med Sci 2025)","quote":"Because AG is primarily explored in experimental medicine, the majority of the research was preclinical studies … AG has demonstrated dual effects—an increase or decrease in blood pressure or in heart rate","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines (Oct 2025), Annex A","quote":"A list of specific prohibited and restricted ingredients is provided in Annex A … This list is not exhaustive. Dealers are responsible to ensure that their products are safe and appropriate for the target consumers.","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (Jan 2026), Tables 4–5","quote":"HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/agmatine-sulfate","label":"iHerb Singapore — Agmatine Sulfate category page (Sports > Nitric Oxide Supplements), default order","quote":"California Gold Nutrition, Sport, Agmatine Sulfate, Unflavored, 3.5 oz (100 g) … Nutricost, Agmatine Sulfate, 120 Capsules (500 mg per Capsule)","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:10.48466+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}