Vitex
Supplement
botanical
women's health
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Pms symptoms — low-to-moderate quality evidence only
When to take
Daily
Studied for
Studies ran up to about 3 months
Pros & cons
Pros
- NCCIH: generally well tolerated in the short term
- One trial: 20 mg a day did as well as 30 mg
- Side effects reported are generally mild
Cons
- NCCIH: higher-quality evidence is still needed
- A meta-analysis flags high risk of bias in trials
- Nausea, stomach pain, headache and itching occur
Sources
- NCCIH — Chasteberry (How Much Do We Know?), last updated April 2025 · read 2026-08-27
what it says
“Several studies of low-to-moderate quality in people have evaluated chasteberry for alleviating PMS symptoms such as breast pain or tenderness. There isn't a lot of strong research on the effectiveness of chasteberry for other conditions.”
- NCCIH — Chasteberry (What Have We Learned: PMS) · read 2026-08-27
what it says
“Some research has suggested that chasteberry might reduce PMS symptoms such as breast pain or tenderness, but higher-quality evidence is needed to reach any definitive conclusions.”
- NCCIH — Chasteberry (What Do We Know About Safety) · read 2026-08-27
what it says
“Chasteberry is generally well tolerated in the short term. Chasteberry fruit extract has been used safely in research studies for up to 3 months. Side effects are generally mild and may include nausea, stomach pain, diarrhea, headache, or itching.”
- NCCIH — Chasteberry (Safety: hormone-sensitive conditions) · read 2026-08-27
what it says
“Chasteberry supplementation may not be safe for women with hormone-sensitive conditions, such as breast, uterine, or ovarian cancer.”
- NCCIH — Chasteberry (Safety: pregnancy and breastfeeding) · read 2026-08-27
what it says
“The use of chasteberry during pregnancy or while breastfeeding may be unsafe.”
- NCCIH — Chasteberry (Keep in Mind: medicines) · read 2026-08-27
what it says
“If you take any type of medicine, talk with your health care provider before using any herbal product; some herbs and medicines interact in harmful ways.”
- Premenstrual syndrome: new insights into etiology and review of treatment methods (Modzelewski et al., Front Psychiatry 2024) — section 5.1 on Vitex agnus-castus · read 2026-08-27
what it says
“Another study by Schellenberg et al. revealed that the most optimal therapeutic effects were achieved with a 20 mg dose taken once daily, with no additional benefits observed when increasing the dose to 30 mg”
- Modzelewski et al. 2024 — section 5.1, on the Verkaik et al. meta-analysis of vitex in PMS · read 2026-08-27
what it says
“In their meta-analysis on VAC studies in PMS, they highlighted the high risk of bias, heterogeneity, subjective methods, and underpowered inclusion criteria, collectively diminishing the quality of evidence regarding the effectiveness of VAC”
- HSA — Guidelines on Prohibited and Restricted Ingredients in HS and TM, Version 1 (Oct 2025), Annex A and Annex B — searched, no row for this ingredient · read 2026-08-27
what it says
“A list of such ingredients and recommended risk mitigation measures can be found in Annex B. This list is not exhaustive. Dealers are responsible to ensure that their products are safe”
- iHerb Singapore — Vitex (Chaste Berry) category (default order, 1 - 27 of 27 results) · read 2026-08-27
what it says
“Nature's Way, Vitex Fruit, 400 mg … Swanson Vitamins, Full Spectrum® Chasteberry Fruit, 400 mg … Solaray, True Herbs, Vitex, 400 mg … Gaia Herbs, Women, Vitex Berry … Nature's Answer, Chasteberry Vitex Agnus Castus, Fluid Extract”
Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.