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Vitamin B6

Supplement vitamin general nutritionbrain & mood
Aka: pyridoxine, pyridoxine hydrochloride, pyridoxal 5'-phosphate
Brands seen in Singapore: GNC
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Protein and amino-acid metabolism · 100+ enzyme reactions
When to take
No timing rule
Take with
Water · absorbed from supplements much like food B6
Pros & cons
Pros
  • RDA is small — 1.3 mg a day for adults 19–50
  • In multis, b-complex and stand-alone forms
  • Pyridoxine hcl is the most common form; p5p also sold
Cons
  • Neuropathy reported above 100 mg/day taken long term
  • UL is 100 mg/day · HSA caps supplements at 100 mg/day
  • High doses: skin lesions, photosensitivity, nausea
Sources
  1. NIH ODS — Vitamin B6 (Health Professional), updated June 16, 2023 · read 2026-08-27
    what it says
    “19–50 years: Male 1.3 mg, Female 1.3 mg … 51+ years: Male 1.7 mg, Female 1.5 mg … [UL] 19+ years: 100 mg … involved in more than 100 enzyme reactions, mostly concerned with protein metabolism … chronic administration of 1–6 g oral pyridoxine per day for 12–40 months can cause severe and progressive sensory neuropathy … several reports show sensory neuropathy occurring at doses lower than 500 mg/day … the symptoms usually stop if the patient discontinues the pyridoxine supplements … painful, disfiguring dermatological lesions; photosensitivity; and gastrointestinal symptoms, such as nausea and heartburn … Absorption of vitamin B6 from supplements is similar to that from food sources … it quickly eliminates most of the vitamin in the urine … The most common vitamin B6 vitamer in supplements is pyridoxine (in the form of pyridoxine hydrochloride [HCl]), although some supplements contain PLP … Cycloserine increases urinary excretion of pyridoxine. Pyridoxine supplements can help prevent these adverse effects … Valproic acid, carbamazepine, and phenytoin increase the catabolism rate of vitamin B6 vitamers, resulting in low plasma PLP concentrations … Pyridoxine supplementation (200 mg/day for 12–120 days) can reduce serum concentrations of phenytoin and phenobarbital … Patients treated with theophylline often have low plasma PLP concentrations … Before taking a vitamin B6 supplement, pregnant women should consult a physician because doses could approach the UL”
  2. HSA Singapore — High-dose vitamin B6 and risk of peripheral neuropathy (announcement, 15 May 2023) · read 2026-08-27
    what it says
    “Peripheral neuropathy has been reported following chronic high-dose (>100mg/day) consumption of vitamin B6 … The maximum allowable daily limit for vitamin B6 in health supplements is 100mg/day based on data from several long-term studies”
  3. HSA Singapore — Health Supplements Guidelines, GL-CHPB-3-001 Rev. No. 020, January 2026 (clause 4.8 + Table 4 Vitamins Limits) · read 2026-08-27
    what it says
    “4.8 HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5 … Table 4: Vitamins Limits … Nutrient … Maximum Daily Limit … Vitamin B6 100mg”
  4. FDA — Daily Value on the Nutrition and Supplement Facts Labels (Reference Guide: Daily Values for Nutrients), content current as of 03/05/2024 · read 2026-08-27
    what it says
    “Vitamin B6 … 1.7mg … DVs are the recommended amounts of nutrients to consume or not to exceed each day”
  5. Watsons Singapore — GNC Vitamin B6 100mg Tablet (retail listing, SGD) · read 2026-08-27
    what it says
    “Vitamin B6 100mg Tablet 60s … Take one tablet daily”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.