Vitamin B3

“Niacin is the generic name for nicotinic acid (pyridine-3-carboxylic acid), nicotinamide (niacinamide or pyridine-3-carboxamide), and related derivatives … More than 400 enzymes require NAD to catalyze reactions in the body”

“NAD is primarily involved in catabolic reactions that transfer the potential energy in carbohydrates, fats, and proteins to adenosine triphosphate (ATP), the cell's primary energy currency”

“Even when taken in very high doses of 3–4 g, niacin is almost completely absorbed”

“Table 1: Recommended Dietary Allowances (RDAs) for Niacin … 19+ years 16 mg NE 14 mg NE 18 mg NE 17 mg NE … The DV for niacin is 16 mg for adults and children age 4 years and older”

“Nicotinic acid and nicotinamide are the two most common forms of niacin in supplements. Some niacin-only supplements contain 500 mg or more per serving … Nicotinamide does not produce skin flushing because of its slightly different chemical structure”

“Most people in the United States consume more than the RDA for niacin … 10% of all individuals age 2 and older who took dietary supplements had total niacin intakes that reached or exceeded the UL”

“Severe niacin deficiency leads to pellagra, a disease characterized by a pigmented rash or brown discoloration on skin exposed to sunlight; the skin also develops a roughened, sunburned-like appearance”

“Although nicotinic acid is a nutrient, if very high doses (thousands of mg) are taken to treat hyperlipidemias, the supplement is being used as a drug. Such doses should only be taken with medical approval and supervision”

“Thirty to 50 mg or more nicotinic acid typically causes flushing … accompanied by burning, tingling, and itching sensations … Supplement users can reduce the flushing effects by taking nicotinic acid supplements with food, slowly increasing the dose over time”

“pharmacologic doses of 1,000 to 3,000 mg/day, nicotinic acid can also cause more serious adverse effects … hypotension severe enough to increase the risk of falls … High doses of nicotinic acid taken over months or years can also be hepatotoxic”

“impaired glucose tolerance and insulin resistance; gastrointestinal effects, such as nausea, heartburn, and abdominal pain; and ocular effects, such as blurred or impaired vision … Hepatotoxicity is more likely to occur with the use of extended-release forms of nicotinic acid”

“the American College of Cardiology and the American Heart Association recommend measuring hepatic transaminase, fasting blood glucose or hemoglobin A1C, and uric acid levels in all supplement users before they start therapy”

“Nicotinamide does not cause skin flushing and has fewer adverse effects than nicotinic acid, and these effects typically begin with much higher doses [12]. Nausea, vomiting, and signs of liver toxicity can occur with nicotinamide intakes of 3,000 mg/day”

“The FNB has established ULs for niacin that apply only to supplemental niacin … These ULs are based on the levels associated with skin flushing … applies to both forms of supplemental niacin … 19+ years 35 mg”

“Isoniazid and pyrazinamide … are structural analogs of niacin and interrupt the production of niacin from tryptophan … isoniazid can interfere with niacin's conversion to NAD … pellagra can occur”

“Large doses of nicotinic acid can raise blood glucose levels by causing or aggravating insulin resistance … nicotinic acid doses of 1.5 g/day or more are most likely to increase blood glucose levels … might require dose adjustments”

“Table 4: Vitamins Limits … Nicotinic acid 15mg Nicotinamide 450mg … Help in energy metabolism in the body … Vitamin B2, B3, B5, B6, B12 … Contribute to maintenance of normal skin … Biotin, vitamin A, B2, B3”

“75. Nicotinamide Restricted use in HS and TM Maximum Daily Dose … should not provide more than 450mg 76. Nicotinic acid Restricted use in HS and TM Maximum Daily Dose … should not provide more than 15mg”

“Niacin 16mg NE … mg NE = milligrams of niacin equivalents … DVs are the recommended amounts of nutrients to consume or not to exceed each day”

“1 - 48 of 274 results … California Gold Nutrition, NMN, 175 mg … NOW Foods, Niacinamide, 500 mg … ProHealth Longevity, NMN Pro™ 1000 … Life Extension, Vitamin B3 Niacin, 500 mg … NOW Foods, Niacin, 500 mg … Thorne, ResveraCel®”