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Tiotropium

Medication long-acting antimuscarinic bronchodilator respiratory
Aka: Spiriva
Brands seen in Singapore: Spiriva Respimat, Spiolto Respimat
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
HealthHub: long-term copd control · SG label adds asthma
When to take
SG label: two puffs once daily, SAMe time of the day
Take with
Inhaled · a separate reliever covers sudden symptoms
Pros & cons
Pros
  • HealthHub: opens the airways so air moves more easily
  • SG label: once daily, and from age 6 in asthma
  • US label: also reduces copd exacerbations
Cons
  • US label: not for relief of acute bronchospasm
  • HealthHub: dry mouth, constipation, fast heart beat
  • HealthHub: can worsen difficulty passing urine
Sources
  1. HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally) · read 2026-08-27
    what it says
    “Both registered tiotropium products read 'Prescription Only' — SPIRIVA RESPIMAT RE-USABLE SOLUTION FOR INHALATION 2.5 MICROGRAM (R03BB04) and SPIOLTO RESPIMAT RE-USABLE 2.5/2.5 MICROGRAM, tiotropium with olodaterol (R03AL06)”
  2. National Drug Formulary (SG, MOH) — SPIRIVA RESPIMAT RE-USABLE SOLUTION FOR INHALATION 2.5 MICROGRAM [SIN15885P], sections 4.1–4.3, last updated 28 Jul 2026 · read 2026-08-27
    what it says
    “The recommended dose for adults is 5 microgram tiotropium given as two puffs from the Respimat inhaler once daily, at the same time of the day. The recommended dose should not be exceeded.”
  3. HealthHub (MOH Singapore / Pharmaceutical Society of Singapore) — Tiotropium medication leaflet · read 2026-08-27
    what it says
    “Tiotropium inhaler is used for the long term treatment of people who have chronic obstructive pulmonary disease (COPD) … Tiotropium works by opening up the airways and make it easier for air to move in and out of the lungs”
  4. HealthHub — Tiotropium leaflet: precautions and common side effects · read 2026-08-27
    what it says
    “Narrow-angle glaucoma … Prostate problems or difficulty passing urine … Heart conditions such as irregular heart beats … Fast heart beat. Dry mouth. Nausea. Constipation. Headache”
  5. US FDA label — SPIRIVA RESPIMAT (tiotropium bromide, Boehringer Ingelheim), section 1 Indications and Usage, via openFDA (effective 17 Aug 2026) · read 2026-08-27
    what it says
    “The long-term, once-daily, maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD), and for reducing COPD exacerbations … Limitation of Use: Not indicated for relief of acute bronchospasm”
  6. US FDA label — SPIRIVA RESPIMAT, section 2 Dosage and Administration, via openFDA · read 2026-08-27
    what it says
    “To receive the full dosage of medication, SPIRIVA RESPIMAT must be administered as two inhalations once-daily. Do not take more than one dose (2 inhalations) in 24 hours.”
  7. US FDA label — SPIRIVA RESPIMAT, sections 4 and 5 Contraindications, Warnings and Precautions, via openFDA · read 2026-08-27
    what it says
    “should not be used for the relief of acute symptoms … In the event of an acute attack, a rapid-acting beta2-agonist should be used … Worsening of narrow-angle glaucoma may occur … Worsening of urinary retention may occur”
  8. US FDA label — SPIRIVA RESPIMAT, section 7 Drug Interactions, via openFDA · read 2026-08-27
    what it says
    “has been used concomitantly with short-acting and long-acting sympathomimetic (beta-agonists) bronchodilators, methylxanthines, oral and inhaled steroids … without increases in adverse reactions … Avoid administration … with other anticholinergic-containing drugs”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.