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Timolol

Medication beta blocker (ophthalmic) other
Aka: Timoptol
Brands seen in Singapore: Timoptol, Timolol-POS, Timabak, Timo-COMOD, Cosopt
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
High pressure inside the eye, often from glaucoma
When to take
SG label: usually one drop twice a day in the affected eye
Take with
No food link · NHS: eyes closed, corner pressed for 2 min
Pros & cons
Pros
  • SG label: 0.25% and 0.5% strengths are registered
  • SG label: many patients move to once-a-day therapy
  • NHS: pressing the eye corner limits body absorption
Cons
  • NHS: blurred vision, stinging, redness, headache
  • SG label: asthma and some heart problems rule it out
  • NHS: some drug reaches the blood, with wider effects
Sources
  1. HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, cached in full and filtered locally) · read 2026-08-27
    what it says
    “All 20 timolol-containing products carry Forensicclassification 'Prescription Only'; 4 are timolol alone — SIN04135P TIMOPTOL OPHTHALMIC SOLUTION 0.5% · SIN09709P TIMOLOL-POS EYE DROPS 0.5% · SIN11054P TIMABAK EYEDROPS 0.5% · SIN13744P TIMO-COMOD 0.5% EYE DROPS · SIN11643P COSOPT”
  2. Singapore National Drug Formulary — TIMOPTOL OPHTHALMIC SOLUTION 0.5% [SIN04135P], indications · read 2026-08-27
    what it says
    “TIMOPTOL is indicated for the reduction of elevated intraocular pressure … Patients with ocular hypertension · Patients with chronic open-angle glaucoma · Aphakic patients with glaucoma”
  3. Singapore National Drug Formulary — TIMOPTOL [SIN04135P], dosage and administration · read 2026-08-27
    what it says
    “The usual starting dose is one drop of … 0.25 % in the affected eye(s) twice a day … the dosage may be changed to one drop of 0.5 % solution in the affected eye(s) twice a day”
  4. Singapore National Drug Formulary — TIMOPTOL [SIN04135P], dosage and administration (continued) · read 2026-08-27
    what it says
    “If the intraocular pressure is maintained at satisfactory levels, many patients can be placed on once-a-day therapy … The use of two topical beta-adrenergic blocking agents is not recommended.”
  5. Singapore National Drug Formulary — TIMOPTOL [SIN04135P], administration technique · read 2026-08-27
    what it says
    “When using nasolacrimal occlusion or closing eyelids for 2 minutes, the systemic absorption is reduced. This may result in an increase in local activity.”
  6. Singapore National Drug Formulary — TIMOPTOL [SIN04135P], contraindications · read 2026-08-27
    what it says
    “Reactive airway disease, bronchial asthma or with a history of bronchial asthma, or severe chronic obstructive pulmonary disease · Sinus bradycardia; sick sinus syndrome; sino-atrial block; second and third degree atrioventricular block; overt cardiac failure; cardiogenic shock”
  7. US FDA label for Timoptic in Ocudose (timolol maleate ophthalmic solution), DOSAGE AND ADMINISTRATION, via openFDA (effective 2026-08-06) · read 2026-08-27
    what it says
    “Dosages above one drop of 0.5% timolol maleate ophthalmic solution twice a day generally have not been shown to produce further reduction in intraocular pressure.”
  8. NHS — Timolol eye drops: what timolol eye drops are for · read 2026-08-27
    what it says
    “Timolol eye drops are a type of medicine called a beta blocker … They are used to treat high pressure in your eyes, which is often caused by glaucoma. The eye drops lower the pressure.”
  9. NHS — Timolol eye drops: how to use timolol eye drops · read 2026-08-27
    what it says
    “After putting the drops in your eye, close your eye and gently press your finger into the corner of your eye (by your nose) for 2 minutes. This helps keep the drops in your eye.”
  10. NHS — Timolol eye drops: side effects · read 2026-08-27
    what it says
    “blurred vision · eye irritation, such as burning, stinging, itching and redness · headache · feeling sick (nausea) and being sick (vomiting)”
  11. NHS — Timolol eye drops: systemic absorption · read 2026-08-27
    what it says
    “After using timolol eye drops, some of the medicine passes into your blood. This may cause other side effects, such as tummy ache, pins and needles and problems sleeping.”
  12. NHS — Timolol eye drops: who can and cannot use them · read 2026-08-27
    what it says
    “you have a breathing problem, such as asthma or chronic obstructive pulmonary disease (COPD) · you have a heart condition, such as a slow or irregular heartbeat, or heart failure · you're having an operation”
  13. NHS — Timolol eye drops: using them with other medicines · read 2026-08-27
    what it says
    “other types of beta blockers taken as tablets or used as eye drops · medicines used to treat high blood pressure, such as nifedipine and clonidine · any medicine that is used to treat diabetes · digoxin”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.