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Strontium

Supplement trace mineral bone & joint
Aka: strontium citrate
Brands seen in Singapore: Life Extension, Vitacost, Dr. Mercola, Swanson Vitamins, Nutricost
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Bone density in trials that blended it with other nutrients
Take with
Food, milk and calcium cut absorption of the drug salt
Pros & cons
Pros
  • A one-year RCT saw bmd gains — from a 4-nutrient blend
Cons
  • Eu restricted the strontium drug over heart risk
  • Strontium inflates dxa bone-density readings
  • The trials measured bone density, not fractures
Sources
  1. European Medicines Agency — Protelos/Osseor (strontium ranelate) Article 20 referral, CHMP outcome February 2014, EC decision 15 April 2014 · read 2026-08-27
    what it says
    “Protelos/Osseor must not be used in patients with established, current or past history of ischaemic heart disease, peripheral arterial disease and/or cerebrovascular disease, or those with uncontrolled hypertension.”
  2. EMA — Protelos (strontium ranelate) Summary of Product Characteristics, section on BMD measurement · read 2026-08-27
    what it says
    “increased X-ray absorption of strontium as compared to calcium, leads to an amplification of bone mineral density (BMD) measurement by dual-photon X-ray absorptiometry (DXA) … approximately 50% of the measured change in BMD over 3 years”
  3. EMA — Protelos SmPC, section 4.5 Interaction with other medicinal products · read 2026-08-27
    what it says
    “Food, milk and derivative products, and medicinal products containing calcium may reduce the bioavailability of strontium ranelate by approximately 60-70% … simultaneous administration of strontium ranelate with these medicinal products is not recommended”
  4. Maria et al. — Melatonin-micronutrients Osteopenia Treatment Study (MOTS), a one-year double-blind RCT (Aging 2017;9:256-85) · read 2026-08-27
    what it says
    “This one-year double blind randomized control trial assessed the effects of nightly melatonin, strontium (citrate), vitamin D3 and vitamin K2 … Compared to placebo, MSDK treatment increased BMD in lumbar spine (4.3%) and left femoral neck (2.2%)”
  5. MOTS 2017 (Aging) — doses used, compared with the earlier COMB study · read 2026-08-27
    what it says
    “Higher doses of strontium (citrate; 680 mg) and vitamin K 2 (100 mcg) were used in COMB compared to our study, which used 450 mg of strontium (citrate) and 60 mcg of vitamin K 2”
  6. MOTS 2017 (Aging) — which single component drove osteoblast differentiation in vitro · read 2026-08-27
    what it says
    “Melatonin was the only component that increased transwell osteoblast differentiation vs. osteogenic medium containing vehicle”
  7. HSA Singapore — Prohibited and Restricted Ingredients in HS and TM, GL-CHPB-1-012 Rev. 001 (Oct 2025), clauses 3.1–3.2; strontium appears in neither Annex A nor Annex B, and is absent from Table 5 of the Health Supplements Guidelines · read 2026-08-27
    what it says
    “A list of these substances which TM and HS should not contain except subject to such restrictions and conditions to ensure safety in Singapore is provided in Annex A. This list is not exhaustive.”
  8. iHerb Singapore — Strontium category page, default “Featured” order, 16 results (brands from positions 1–6) · read 2026-08-27
    what it says
    “Life Extension, Strontium Caps, 90 Vegetarian Capsules (250 mg per Capsule) … Vitacost, Strontium (340 mg per Capsule) … Dr. Mercola, Bone Support with Strontium & Boron … Swanson Vitamins, Strontium Citrate, 340 mg … Nutricost, Strontium”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.