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Rehmannia

Supplement botanical general nutrition
Aka: Rehmannia glutinosa, shu di huang, di huang
Brands seen in Singapore: Dragon Herbs
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
A tcm formula herb — little standalone human evidence
Pros & cons
Pros
  • Long use as the lead herb in classic tcm formulas
  • A 17-trial pooled review saw no severe adverse events
  • Gut-microbiota and immune effects seen in lab studies
Cons
  • Reviewers point plainly to a lack of human trials
  • That pooled review flags flaws and high heterogeneity
  • Only one rehmannia product is listed on iherb SG
Sources
  1. Rehmannia glutinosa polysaccharides: a review on structural features, pharmacological potential, and advanced delivery systems (Wang et al., Front Nutr 2026) · read 2026-08-27
    what it says
    “RGPs … exhibit diverse bioactivities including immunomodulation … Pharmacological studies show RGPs modulate gut microbiota … However, clinical application requires addressing batch variability, scalability, and the lack of human trials.”
  2. Rehmannia glutinosa for perimenopausal syndrome in patients with breast cancer: A systematic review and meta-analysis (Saudi Med J 2025) · read 2026-08-27
    what it says
    “The meta-analysis included 17 RCTs involving 1,139 patients showing that CHM with Rehmannia glutinosa as the monarch drug … no severe adverse reactions were detected … the methodological flaws and high heterogeneity of the included RCTs.”
  3. HSA Singapore — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (Oct 2025), Annex A (118 rows) and Annex B (4 rows) — rehmannia / Rehmannia glutinosa / shu di huang / di huang NOT LISTED in either annex · read 2026-08-27
    what it says
    “The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.”
  4. HSA Singapore — Health Supplements Guidelines GL-CHPB-3-001 Rev. No. 020 (January 2026), clause 4.8 with Tables 4-5 (vitamins and minerals only — no botanical rows) · read 2026-08-27
    what it says
    “4.8 HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.”
  5. iHerb Singapore — Rehmannia category page, default listing order · read 2026-08-27
    what it says
    “1 - 1 of 1 result … Dragon Herbs, Rehmannia Six Combination, 100 Vegetarian Capsules”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.