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Medroxyprogesterone

Medication progestogen hormonal
Aka: Provera, Depo-Provera
Brands seen in Singapore: Provera, Depo-Provera
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Prescribed for abnormal uterine bleeding, and for hrt
When to take
HealthHub: after food, at the SAMe time each day
Take with
Food · HealthHub: taken after food to ease stomach upset
Pros & cons
Pros
  • HealthHub: a progestogen for heavy or absent periods
  • FDA: oral label states 5 or 10 mg daily for 5–10 days
  • Depo-provera: one 150 mg injection every 3 months
Cons
  • Boxed warning: clot, stroke, breast-cancer risk in hrt
  • Depo boxed warning: significant bone mineral loss
  • HealthHub: nausea, breast tenderness, mood swings
Sources
  1. HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows; cached at /tmp/hsa_all.json and filtered locally, not re-fetched) · read 2026-08-27
    what it says
    “All 3 registered medroxyprogesterone products read Forensicclassification 'Prescription Only' — SIN10513P PROVERA TABLET 5 mg · SIN03841P PROVERA TABLET 10 mg (G03DA02) · SIN04540P DEPO-PROVERA STERILE AQUEOUS SUSPENSION 50 mg/ml (G03AC06)”
  2. HealthHub (Pharmaceutical Society of Singapore) — Medroxyprogesterone: what is this medication for · read 2026-08-27
    what it says
    “Medroxyprogesterone is a type of progestogen … Management of various abnormal uterine bleeding including absence of menstrual flow and heavy menstrual bleeding … Management of menopause in combination with estrogen replacement therapy”
  3. HealthHub — Medroxyprogesterone: how should I take or use this medication · read 2026-08-27
    what it says
    “This medicine should be taken after food … Take medication at the same time every day to avoid huge changes in the hormone levels in your body”
  4. HealthHub — Medroxyprogesterone: common side effects · read 2026-08-27
    what it says
    “Stomach discomfort, nausea and vomiting. Take it after food to reduce these side effects. Breast tenderness. Headache … Dizziness, drowsiness … Weight changes, mood swings … Skin pigmentation.”
  5. US FDA label for medroxyprogesterone acetate tablets (Mylan), Indications and Usage, via openFDA (effective 2026-05-21) · read 2026-08-27
    what it says
    “indicated for the treatment of secondary amenorrhea and abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology … prevention of endometrial hyperplasia in nonhysterectomized postmenopausal women”
  6. US FDA label for medroxyprogesterone acetate tablets (Mylan), Dosage and Administration, via openFDA · read 2026-08-27
    what it says
    “MPA tablets may be given in dosages of 5 or 10 mg daily for 5 to 10 days … 10 mg of MPA daily for 10 days … Patients should be started at the lowest dose”
  7. US FDA label for medroxyprogesterone acetate tablets (Mylan), Contraindications, via openFDA · read 2026-08-27
    what it says
    “Undiagnosed abnormal genital bleeding. Known, suspected, or history of breast cancer … Active DVT, PE, or a history of these conditions … Known liver impairment or disease. Known or suspected pregnancy.”
  8. US FDA label for medroxyprogesterone acetate tablets (Mylan), Boxed Warning, via openFDA · read 2026-08-27
    what it says
    “reported an increased risk of deep vein thrombosis (DVT), pulmonary embolism (PE), stroke and myocardial infarction (MI) … an increased risk of developing probable dementia … an increased risk of invasive breast cancer”
  9. US FDA label for DEPO-PROVERA CI (medroxyprogesterone acetate injectable suspension), section 2, via openFDA (effective 2025-12-18) · read 2026-08-27
    what it says
    “The recommended dose is 150 mg of Depo-Provera CI every 3 months (13 weeks) administered by deep, intramuscular (IM) injection in the gluteal or deltoid muscle.”
  10. US FDA label for DEPO-PROVERA CI, Boxed Warning, via openFDA · read 2026-08-27
    what it says
    “Women who use Depo-Provera Contraceptive Injection (Depo-Provera CI) may lose significant bone mineral density. Bone loss is greater with increasing duration of use and may not be completely reversible.”
  11. US FDA label for DEPO-PROVERA CI, section 7 Drug Interactions, via openFDA · read 2026-08-27
    what it says
    “Some drugs or herbal products that may decrease the effectiveness of hormonal contraceptives include: barbiturates, bosentan, carbamazepine, felbamate, griseofulvin, oxcarbazepine, phenytoin, rifampin, St. John's wort, topiramate”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.