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Lycopene

Supplement carotenoid men's healthheart & metabolic
Aka: tomato extract
Brands seen in Singapore: California Gold Nutrition, 21st Century, Swanson Vitamins, NOW Foods, Nutricost
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Sperm-quality markers · blood levels track artery imt
Studied for
Trials ran 3 months; optimal dose and duration undefined
Pros & cons
Pros
  • Pooled trials: sperm concentration up (smd 0.33)
  • Higher blood lycopene tracked lower carotid imt
  • That imt link was stronger in men (or 0.62)
Cons
  • Only 4 trials, 151 men — publication bias noted
  • No effect on motility, morphology, volume or DNA damage
  • Imt data are cross-sectional blood levels, not trials
Sources
  1. NIH ODS — Vitamin A and Carotenoids (Health Professional): non-provitamin A carotenoids (read from a cached copy of the sheet already on disk) · read 2026-08-27
    what it says
    “Other carotenoids in food, such as lycopene, lutein, and zeaxanthin, are not converted into vitamin A and are referred to as non-provitamin A carotenoids”
  2. Association of Lycopene and Male Reproductive Health: Systematic Review and Meta-Analysis (2025) · read 2026-08-27
    what it says
    “Lycopene supplementation significantly improved sperm concentration (SMD 0.33, 95% CI [0.02–0.65], p = 0.037) and nonprogressive motility (SMD 0.45, 95% CI [0.04–0.87], p = 0.032).”
  3. Lycopene and Male Reproductive Health SR/MA (2025) — evidence base size · read 2026-08-27
    what it says
    “Four clinical studies involving 151 participants were included.”
  4. Lycopene and Male Reproductive Health SR/MA (2025) — null outcomes · read 2026-08-27
    what it says
    “No statistically significant effects were observed on total motility, progressive motility, normal or abnormal morphology, semen volume, or DNA damage.”
  5. Lycopene and Male Reproductive Health SR/MA (2025) — limitations · read 2026-08-27
    what it says
    “Sensitivity analyses showed that the findings were generally robust, although publication bias and methodological heterogeneity were noted.”
  6. Lycopene and Male Reproductive Health SR/MA (2025) — doses and duration used · read 2026-08-27
    what it says
    “Lycopene supplementation ranged in dose from 2 mg/day to 30 mg/day, administered over a duration of 3 months in all studies. … The optimal duration and dose of lycopene supplementation are still not well defined.”
  7. Circulating Lycopene and β-Carotene Levels Are Inversely Associated with Carotid Intima-Media Thickness: SR and Meta-Analysis (2026; 13 studies, n=9,131) · read 2026-08-27
    what it says
    “High circulating lycopene levels were significantly associated with low IMT (pooled OR = 0.70; 95% CI: 0.59–0.84; I 2 = 65.7%).”
  8. Circulating Lycopene and Carotid IMT SR/MA (2026) — sex difference · read 2026-08-27
    what it says
    “The association was stronger in men (OR = 0.62; 95% CI: 0.45–0.84) than in women (OR = 0.74; 95% CI: 0.58–0.95).”
  9. Circulating Lycopene and Carotid IMT SR/MA (2026) — study design included · read 2026-08-27
    what it says
    “Observational and experimental studies reporting cross-sectional associations between plasma carotenoids and IMT were included.”
  10. HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev 001 (Oct 2025), Annex A/B — searched, no row for this ingredient · read 2026-08-27
    what it says
    “The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.”
  11. iHerb Singapore — Lycopene category (default order, 1 - 25 of 25 results) · read 2026-08-27
    what it says
    “California Gold Nutrition, AstaCarotenoid Complex with Lutein, Lycopene, Astaxanthin, and Vitamin A … 21st Century, Lycopene, 25 mg … Swanson Vitamins, Lycopene, 20 mg … NOW Foods, Lycopene, 20 mg … Nutricost, Lycopene, 20 mg”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.