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Domperidone

Medication prokinetic antiemetic digestive
Aka: Motilium
Brands seen in Singapore: Motilium, Domper, Gastrium, Dompel, Peptomet
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Nausea and vomiting · fullness, bloating after meals
When to take
SG label: 15–30 minutes before meals
Take with
Before food · grapefruit is named as an interaction
Pros & cons
Pros
  • HealthHub: relieves nausea, vomiting and indigestion
  • Tablets, suspension and suppositories are registered
  • SG label: usually a week or less for acute nausea
Cons
  • Dry mouth, headache and diarrhoea are reported
  • Heart rhythm risk rises above 30 mg a day
  • 60 or older, or heart or kidney disease — flagged
Sources
  1. HSA — Listing of Registered Therapeutic Products (data.gov.sg d_767279312753558cbf19d48344577084), Forensicclassification column; cached at /tmp/hsa_all.json and filtered locally, not re-fetched · read 2026-08-27
    what it says
    “MOTILIUM TABLET 10 mg SIN02500P · MOTILIUM SUSPENSION 1 mg/ml SIN02891P · DOMPER TABLET 10 mg SIN06751P · DOMPER SUPPOSITORY 10 mg SIN09583P · GASTRIUM SIN10198P · DOMPEL SIN10187P · PEPTOMET SIN10180P — all 9 rows 'Prescription Only'”
  2. MOH National Drug Formulary (Singapore) — MOTILIUM TABLET 10 MG [SIN02500P], product information · read 2026-08-27
    what it says
    “MOTILIUM TABLET 10 MG [SIN02500P] … DOMPERIDONE - 10 MG … Forensic Classification PRESCRIPTION ONLY MEDICINES … Anatomical Therapeutic Chemical (ATC) code … A03FA03”
  3. MOH National Drug Formulary (Singapore) — MOTILIUM TABLET 10 MG [SIN02500P], prescription-only exemption for supply without prescription · read 2026-08-27
    what it says
    “Prescription-only Medicines with Exemptions for Supply without Prescription … As an oral solid preparation containing not more than 10mg … Maximum Daily Dose: 30 mg … Maximum supply: 14 days … Minimum age: 12 years”
  4. MOH National Drug Formulary (Singapore) — MOTILIUM TABLET 10 MG [SIN02500P], Dosage and Administration: timing · read 2026-08-27
    what it says
    “It is recommended to take oral domperidone 15–30 minutes before meals. If taken after meals, absorption of the drug is somewhat delayed.”
  5. MOH National Drug Formulary (Singapore) — MOTILIUM TABLET 10 MG [SIN02500P], Dosage: adults and adolescents ≥12 years, ≥35 kg · read 2026-08-27
    what it says
    “The dose of domperidone should be the lowest effective dose for the individual situation (typically 30mg/day) and can be increased if necessary to a maximum daily oral dose of 40mg.”
  6. MOH National Drug Formulary (Singapore) — MOTILIUM TABLET 10 MG [SIN02500P], Dosage: caution above 30 mg/day · read 2026-08-27
    what it says
    “Doses above 30mg/day should be used with caution due to potential risk of arrhythmias associated with the higher doses.”
  7. MOH National Drug Formulary (Singapore) — MOTILIUM TABLET 10 MG [SIN02500P], Dosage: treatment duration · read 2026-08-27
    what it says
    “Usually, the maximum treatment duration should not exceed one week for the treatment of acute nausea and vomiting.”
  8. MOH National Drug Formulary (Singapore) — MOTILIUM TABLET 10 MG [SIN02500P], Contraindications · read 2026-08-27
    what it says
    “Domperidone is contraindicated in the following situations: … Prolactin-releasing pituitary tumour (prolactinoma) … Co-administration with QT-prolonging drugs … Co-administration with potent CYP3A4 inhibitors … In patients with moderate or severe hepatic impairment”
  9. HealthHub (MOH Singapore) — Domperidone, medication information leaflet, last reviewed 30 June 2026 · read 2026-08-27
    what it says
    “Domperidone is used to provide relief from nausea and vomiting. It may also be used to provide relief from symptoms of indigestion, such as bloating, excessive fullness, stomach discomfort, excessive burping and heartburn after eating.”
  10. HealthHub (MOH Singapore) — Domperidone, how to take or use it · read 2026-08-27
    what it says
    “Oral tablets/oral syrup: Take half to one hour before food … This medication is usually used for a short period of time, unless advised otherwise by your doctor.”
  11. HealthHub (MOH Singapore) — Domperidone, common and rare side effects · read 2026-08-27
    what it says
    “Dry mouth … Headache or migraine … Diarrhoea … Irritation to the buttocks area (with use of suppository) … Very rarely (affect less than 1% of patients): Abnormal or rapid heartbeat”
  12. HealthHub (MOH Singapore) — Domperidone, precautions · read 2026-08-27
    what it says
    “You have an existing or a history of heart problems (especially rapid, slow or irregular heartbeats) … You are aged 60 years or older … You have kidney or liver disease … a tumour of the pituitary gland called prolactinoma”
  13. HealthHub (MOH Singapore) — Domperidone, food and medication to avoid · read 2026-08-27
    what it says
    “Certain antibiotics, antifungals, antivirals, heart medications, medications to treat mental or mood disorders may increase the risk of side effects when taken with domperidone. Avoid taking grapefruit or grapefruit juice …”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.